Structural studies reveal the mechanism by which the mRNA nuclear export machinery engages with nascent transcripts through interaction with the cap binding complex.
Experiments on mice show that TMC7, a transmembrane channel-like protein, localizes to the cis-Golgi region in spermatids and that this is essential for acrosome biogenesis and male fertility.
Vangl2 induced by inflammation recruits ubiquitin ligase PDLIM2 and increases K63-linked ubiquitination on p65, which promotes the recognition of p65 by cargo receptor NDP52 and the autophagic degradation of p65.
A magnetoencephalography study across different languages shows that life-long listening experience influences the neural mechanisms underlying rhythm perception.
Alessandra Machado Araujo, Joseph D Dekker ... Haley O Tucker
Single-cell RNA-seq data and transgenic models revealed B-plasmacytoid dendritic cells (B-pDCs) represent a phenotypically and functionally distinct common lymphoid progenitor-derived pDC lineage specialized in T cell activation and previously not described in mice.
Rashmi Sukumaran, Achuthsankar S Nair, Moinak Banerjee
Genomic differences in stroke and its comorbid conditions can aid in refining the socio-economic interpretation of risk among different ethnicities and can assist in distinguishing their phenotypic variation.
ePAC, a novel cancer vaccine utilizing a mammalian-derived virus-like particle to co-deliver neoantigens and CpG-ODN, demonstrates strong antitumor efficacy in mouse models.
