Browse the latest research

Page 201 of 1,802
    1. Biochemistry and Chemical Biology

    Disordered proteins interact with the chemical environment to tune their protective function during drying

    Shraddha KC, Kenny H Nguyen ... Thomas C Boothby
    The ability of intrinsically disordered proteins to protect sensitive enzymes during drying can be tuned through interactions with cosolutes.
    1. Immunology and Inflammation

    Development of a new genotype–phenotype linked antibody screening system

    Takashi Watanabe, Hikaru Hata ... Hidehiro Fukuyama
    A Golden Gate-based dual-expression vector enables rapid screening, which facilitates efficient isolation of high-affinity cross-reactive antibodies for therapeutic or diagnostic use and provides a crucial advance for pandemic preparedness.
    1. Neuroscience

    Running modulates primate and rodent visual cortex differently

    John P Liska, Declan P Rowley ... Alexander C Huk
    Although activity in mouse V1 increases substantially during volitional running, such modulations in the foveal/central representation of primate V1 appear much smaller and suppressive.
    1. Cell Biology
    2. Genetics and Genomics

    Multi-species genome-wide CRISPR screens identify conserved suppressors of cold-induced cell death

    Breanna Lam, Kathrin M Kajderowicz ... Sinisa Hrvatin
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Structural Biology and Molecular Biophysics
    2. Plant Biology

    Molecular dynamics simulations illuminate the role of sequence context in the ELF3-PrD-based temperature sensing mechanism in plants

    Richard J Lindsay, Rafael Giordano Viegas ... Sonya M Hanson
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    Patch-walking, a coordinated multi-pipette patch clamp for efficiently finding synaptic connections

    Mighten C Yip, Mercedes M Gonzalez ... Craig R Forest
    Patch-walking is a novel automated patch clamp approach for finding synaptic connections in brain tissue, yielding 80–92% more probed connections than traditional approaches.
    1. Neuroscience

    Electrophysiological dynamics of salience, default mode, and frontoparietal networks during episodic memory formation and recall revealed through multi-experiment iEEG replication

    Anup Das, Vinod Menon
    Human intracranial electroencephalography recordings across 177 participants and four diverse episodic memory experiments demonstrate how the anterior insula node of the salience network orchestrates dynamics of large-scale brain networks.
    1. Physics of Living Systems

    A scale-invariant log-normal droplet size distribution below the critical concentration for protein phase separation

    Tommaso Amico, Samuel Toluwanimi Dada ... Amos Maritan
    The scaling invariance of the droplet size distribution as a universal aspect of protein phase separation is reported, providing a quantitative approach to determinate the critical concentration for this process.
    1. Neuroscience

    Brain state and cortical layer-specific mechanisms underlying perception at threshold

    Mitchell P Morton, Sachira Denagamage ... Anirvan S Nandy
    States of elevated arousal and stable retinal images allow enhanced processing of threshold stimuli in the laminar microcircuits of area V4.