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Page 240 of 1,782
    1. Plant Biology

    Single-molecule analysis reveals the phosphorylation of FLS2 governs its spatiotemporal dynamics and immunity

    Yaning Cui, Hongping Qian ... Jinxing Lin
    The phosphorylation of FLS2 may activate flg22-triggered immunity by facilitating the partitioning of FLS2 into functional AtRem1.3-associated nanodomains.
    Version of Record
    Short Report
    • Important
    • Solid
    1. Neuroscience

    Sex differences in discrimination behavior and orbitofrontal engagement during context-gated reward prediction

    Sophie Peterson, Amanda Maheras ... Ronald Keiflin
    Rodent model of context-dependent discrimination reveals sex-biased tradeoff between speed of acquisition and robustness of contextual control over cue-elicited reward seeking, linked to orbitofrontal cortex activation.
    1. Microbiology and Infectious Disease

    Targeting plasmid-encoded proteins that contain immunoglobulin-like domains to combat antimicrobial resistance

    Alejandro Prieto, Luïsa Miró ... Antonio Juarez
    A novel strategy to combat antimicrobial resistance has been identified by using vaccines and nanobodies to target specific extracellular proteins located on multiresistant bacterial plasmids.
    1. Neuroscience

    Sex-peptide targets distinct higher order processing neurons in the brain to induce the female post-mating response

    Mohanakarthik P Nallasivan, Deepanshu ND Singh ... Matthias Soller
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Neuroscience

    Aberrant hippocampal Ca2+ microwaves following synapsin-dependent adeno-associated viral expression of Ca2+ indicators

    Nicola Masala, Manuel Mittag ... Tony Kelly
    Common adeno-associated viral transduction procedures induce artefactual spatially confined Ca2+ waves in the hippocampus.
    1. Structural Biology and Molecular Biophysics

    The mechanism of mammalian proton-coupled peptide transporters

    Simon M Lichtinger, Joanne L Parker ... Philip C Biggin
    The manner in which protons control the conformational behaviour of mammalian peptide transporters is revealed through state-of-the-art molecular dynamics simulations supported by cell-based assays.
    1. Cell Biology
    2. Computational and Systems Biology

    circHIPK3 nucleates IGF2BP2 and functions as a competing endogenous RNA

    Trine Line Hauge Okholm, Andreas Bjerregaard Kamstrup ... Christian Kroun Damgaard
    A dysregulated circular RNA in bladder cancer controls oncogenic pathways by tethering specific RNA-binding proteins, which in turn inhibits their normal functions.
    1. Physics of Living Systems

    Optical mapping of ground reaction force dynamics in freely behaving Drosophila melanogaster larvae

    Jonathan H Booth, Andrew T Meek ... Malte C Gather
    A new optical approach reveals dynamics of ground reaction forces in Drosophila larvae and opens new avenues for studying the biomechanics of movement in small animals.
    1. Developmental Biology

    Drosophila medulla neuroblast termination via apoptosis, differentiation, and gliogenic switch is scheduled by the depletion of the neuroepithelial stem cell pool

    Phuong-Khanh Nguyen, Louise Y Cheng
    The termination of medulla neuroblasts is specified by the depletion of the neuroepithelium and mediated by apoptosis, differentiation, and gliogenic switch.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Non-cognate immunity proteins provide broader defenses against interbacterial effectors in microbial communities

    Abigail Knecht, Denise Sirias ... Karine A Gibbs
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Incomplete