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Page 28 of 1,797
    1. Neuroscience

    TRPV4 activation by TGFβ2 enhances cellular contractility and drives ocular hypertension

    Christopher Nass Rudzitis, Monika Lakk ... David Krizaj
    The TRPV4 channel was identified as an obligatory regulator of physiological and pathological increases in intraocular pressure.
    1. Cell Biology

    Nonequilibrium polysome dynamics promote chromosome segregation and its coupling to cell growth in Escherichia coli

    Alexandros Papagiannakis, Qiwei Yu ... Christine Jacobs-Wagner
    Polysome formation within the nucleoid and repulsion between these major cytoplasmic components provide a self-organizing mechanism for chromosome segregation and modulation of its timing across growth rates in Escherichia coli.
    1. Neuroscience

    Sigh generation in preBötzinger complex

    Yan Cui, Evgeny Bondarenko ... Jack L Feldman
    Activation of NMB/GRP receptors is not necessary for sigh generation, while SST preBötC neurons are critical for generation of sighs.
    1. Cell Biology

    The triad interaction of ULK1, ATG13, and FIP200 is required for ULK complex formation and autophagy

    Yutaro Hama, Yuko Fujioka ... Nobuo N Noda
    AlphaFold-guided in vitro and in vivo analyses establish the mechanism of ULK complex formation and provide a structural basis for understanding its role in mammalian autophagy initiation.
    1. Immunology and Inflammation

    Hypothermia protects against ventilator-induced lung injury by limiting IL-1β release and NETs formation

    Nobuyuki Nosaka, Vanessa Borges ... Kenichi Shimada
    Therapeutic hypothermia mitigates ventilator-induced lung injury by suppressing macrophage-derived IL-1β release, thereby reducing neutrophil extracellular trap formation, vascular leakage, and hypoxemia in a two-hit acute lung injury model.
    1. Cell Biology

    Targeting the WSB2-NOXA Axis in Cancer Cells for Enhanced Sensitivity to BCL-2 Family Protein Inhibitors

    Dongyue Jiao, Kun Chang ... Chenji Wang
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Convincing
    1. Microbiology and Infectious Disease

    HIV-specific CD8+ T-cell responses soon after treatment initiation during acute HIV infection are associated with viral reservoir decline

    Pien M van Paassen, Alexander O Pasternak ... the Netherlands Cohort Study on Acute HIV Infection (NOVA) study team
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Developmental Biology
    2. Neuroscience

    FGF and MafB regulated cadherin expression drives lamina formation in the auditory hindbrain

    Rosanna CG Smith, Maryam Clark ... Stephen R Price
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    Hyperpolarized 13C metabolic imaging detects long-lasting metabolic alterations following mild repetitive traumatic brain injury

    Caroline Guglielmetti, Kai Qiao ... Susanna Rosi
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    • Incomplete
    1. Neuroscience

    Inhibitory circuits generate rhythms for leg movements during Drosophila grooming

    Durafshan Sakeena Syed, Primoz Ravbar, Julie H Simpson
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
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