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    1. Epidemiology and Global Health

    A natural experiment in Kenya reveals durable immunosuppressive effects of early childhood malaria: a longitudinal cohort study

    Mercy S Safari, Timothy O Makori ... Charles J Sande
    Early-life malaria exposure leaves a durable immunological imprint associated with reduced antibody responses to unrelated infections and vaccines.
    1. Structural Biology and Molecular Biophysics

    In silico design and validation of high-affinity RNA aptamers for SARS-CoV-2 comparable to neutralizing antibodies

    Yanqing Yang, Lulu Qiao ... Ruhong Zhou
    Computer-Aided Aptamer Modeling and Optimization (CAAMO) enables structure-guided RNA aptamer affinity maturation, producing a SARS-CoV-2 RBD (receptor binding domain) binder that rivals neutralizing antibodies and retains predicted activity across variants.
    1. Developmental Biology
    2. Plant Biology

    Correction: Control of Arabidopsis shoot stem cell homeostasis by two antagonistic CLE peptide signalling pathways

    Jenia Schlegel, Gregoire Denay ... Rüdiger GW Simon
    1. Biochemistry and Chemical Biology

    A Membrane-Disruptive Action of VBIT-4 Challenges Its Role as a Widely Used VDAC1 Oligomerization Inhibitor

    Varun Ravishankar, Luís Borges-Araújo ... Lucie Bergdoll
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Genetics and Genomics

    Fourfold lifespan extension in C. elegans daf-2 mutant males

    Mike Russell, Michelle Lin ... Liou Y Sun
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Neuroscience

    Relating layer fMRI signals to acoustics and intracranial neuronal activity in the human auditory cortex in a naturalistic design

    Hsin-Ju Lee, Jyrki Ahveninen ... Fa-Hsuan Lin
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Computational and Systems Biology

    Metabolic Trans-Omic Analysis Reveals Key Regulatory Disruption of Energy Metabolism in Alzheimer’s Disease

    Tomoharu Katayama, Hikaru Sugimoto ... Shinya Kuroda
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Neuroscience

    Diverse paths for chemoreception in ciliated neurons contacting the cerebrospinal fluid in the spinal cord

    Emily Verran, Louise Moizan ... Claire Wyart
    Not revised
    Reviewed Preprint v1
    • Useful
    • Convincing
    • Incomplete
    1. Cell Biology

    Cytoplasmic circular dsDNA is a key constituent of stress granules

    Natalia A Demeshkina, Adrian R Ferré-D'Amaré
    Extrachromosomal circular DNA has been identified as a novel component of stress granule cores, indicating its essential involvement in eukaryotic stress response pathways at the level of protein synthesis.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Experimental verification of the error minimization theory using non-standard genetic codes constructed in vitro

    Ryota Miyachi, Norikazu Ichihashi
    The in vitro experiments that used the artificial genetic codes tested here did not provide support for the error minimization theory.
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