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Page 363 of 1,793
    1. Biochemistry and Chemical Biology

    On the role of nucleotides and lipids in the polymerization of the actin homolog MreB from a Gram-positive bacterium

    Wei Mao, Lars D Renner ... Rut Carballido-Lopez
    First 3D-structure and first observation of organized protofilaments of MreB from a Gram-positive bacterium, suggesting a model where ATP drives the formation of dynamic pairs of MreB protofilaments on a lipid surface.
    1. Genetics and Genomics

    Plasma growth hormone pulses induce male-biased pulsatile chromatin opening and epigenetic regulation in adult mouse liver

    Andy Rampersaud, Jeannette Connerney, David J Waxman
    Pulsatile chromatin opening stimulated by naturally-occurring plasma growth hormone pulses is one of two GH-determined mechanisms that establish widespread sex differences in hepatic chromatin accessibility and epigenetic regulation, both closely linked to sex differences in liver gene transcription and function.
    1. Cell Biology
    2. Genetics and Genomics

    LRRC23 truncation impairs radial spoke 3 head assembly and sperm motility underlying male infertility

    Jae Yeon Hwang, Pengxin Chai ... Jean-Ju Chung
    LRRC23 is a radial spoke 3 head component essential for normal sperm motility and fertility in mammals.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Genome-wide Functional Characterization of Escherichia coli Promoters and Sequence Elements Encoding Their Regulation

    Guillaume Urtecho, Kimberly D. Insigne ... Sriram Kosuri
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Cell Biology

    N-WASP-dependent branched actin polymerization attenuates B-cell receptor signaling by increasing the molecular density of receptor clusters

    Anshuman Bhanja, Margaret K Seeley-Fallen ... Wenxia Song
    B-cells generate inner actomyosin foci from lamellipodial actin networks to drive cell contraction on antigen-presenting surfaces, which causes signaling molecule disassociation from B-cell receptor clusters and signal attenuation.
    1. Neuroscience

    Endosomal dysfunction contributes to cerebellar deficits in spinocerebellar ataxia type 6

    Anna A Cook, Tsz Chui Sophia Leung ... Alanna Jean Watt
    Changes in the intracellular trafficking of key signaling molecules in endosomes lead to pathophysiology in a rare disease affecting the cerebellum.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Cervical cancer screening improvements with self-sampling during the COVID-19 pandemic

    Miriam Elfström, Penelope Grace Gray, Joakim Dillner
    Improved cervical cancer prevention through greatly increased population coverage by use of self-sampling and HPV screening during the COVID-19 pandemic.
    1. Evolutionary Biology

    How hibernation in frogs drives brain and reproductive evolution in opposite directions

    Wenbo Liao, Ying Jiang ... Stefan Lüpold
    Rumation of anurans covaried negatively with brain size but positively with reproductive investment, likely in response to brumation-dependent changes in the socio-ecological context and associated selection on different tissues.
    1. Immunology and Inflammation
    2. Neuroscience

    Cystatin F (Cst7) drives sex-dependent changes in microglia in an amyloid-driven model of Alzheimer’s disease

    Michael JD Daniels, Lucas Lefevre ... Barry W McColl
    Cst7, a gene coding for protein cystatin F, is expressed by microglia in neurodegenerative disease models and mediates sex-dependent effects on microglial endolysosomal function and disease pathology.
    1. Biochemistry and Chemical Biology

    Phosphorylation bar-coding of free fatty acid receptor 2 is generated in a tissue-specific manner

    Natasja Barki, Laura Jenkins ... Graeme Milligan
    Differential agonist-induced phosphorylation of free fatty acid receptor 2 is shown in different tissues of transgenic mice engineered to express variant forms of the human ortholog of the receptor.