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Page 377 of 1,792
    1. Evolutionary Biology

    A toxin-antidote selfish element increases fitness of its host

    Lijiang Long, Wen Xu ... Patrick T McGrath
    A toxin-antidote element, identified for its role as a selfish genetic element that spreads through a population by killing certain offspring, also plays a beneficial role to the host.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Asymmetric inheritance of centrosomes maintains stem cell properties in human neural progenitor cells

    Lars N Royall, Diana Machado ... Annina Denoth-Lippuner
    Genetic birthdating in forebrain organoids shows asymmetric inheritance of centrosomes in human neural progenitor cells, required for proper human neurogenesis.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Evolution of haploid and diploid populations reveals common, strong, and variable pleiotropic effects in non-home environments

    Vivian Chen, Milo S Johnson ... Gavin Sherlock
    Pleiotropy of adaptive clones isolated from diverse experimental environment.
    1. Cancer Biology

    Mutant SF3B1 promotes malignancy in PDAC

    Patrik Simmler, Eleonora I Ioannidi ... Gerald Schwank
    SF3B1-K700E, a gene mutaiton found recurrently mutated in pancreatic cancer, increases malignancy in an autochthonous mouse model of pancreatic cancer and induces resistance against TGF-β-induced apoptosis in vitro by missplicing of MAP3K7.
    1. Neuroscience

    Hierarchical temporal prediction captures motion processing along the visual pathway

    Yosef Singer, Luke Taylor ... Nicol S Harper
    Neural network modeling shows that hierarchical application of the simple computational principle of predicting future sensory input from its past can capture features of visual motion processing from the retina to the visual cortex.
    1. Genetics and Genomics
    2. Evolutionary Biology

    Hybridization breaks species barriers in long-term coevolution of a cyanobacterial population

    Gabriel Birzu, Harihara Subrahmaniam Muralidharan ... Devaki Bhaya
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Medicine
    2. Cancer Biology

    Genomic and epigenomic evolution of metastatic prostate cancer: the first warm autopsy in China

    Wenhui Zhang, Yan Wang ... Zhuan Liao
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Genetics and Genomics

    Novel axonemal protein ZMYND12 interacts with TTC29 and DNAH1, and is required for male fertility and flagellum function

    Denis Dacheux, Guillaume Martinez ... Charles Coutton
    Bi-allelic mutations in ZMYND12, encoding a novel axonemal protein interacting with TTC29 and DNAH1, cause male infertility and flagellum defects in human and Trypanosoma.
    1. Computational and Systems Biology
    2. Ecology

    100 years of anthropogenic impact causes changes in freshwater functional biodiversity

    Niamh Eastwood, Jiarui Zhou ... Luisa Orsini
    High-throughput systemic approaches on long-term trends identify the environmental factors that cause loss of biodiversity and disrupt ecosystem functions.
    1. Chromosomes and Gene Expression

    ZMYM2 controls human transposable element transcription through distinct co-regulatory complexes

    Danielle J Owen, Elisa Aguilar-Martinez ... Andrew D Sharrocks
    The transcriptional regulator ZMYM2 homes to distinct classes of retrotransposons bound by the TRIM28 and ChAHP chromatin complexes in human cells, which is broadly relevant in the transcriptional regulation field.