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Page 405 of 1,800
    1. Microbiology and Infectious Disease

    Evolution of a functionally intact but antigenically distinct DENV fusion loop

    Rita M Meganck, Deanna Zhu ... Longping V Tse
    Operating as a serum profiling tool for dengue infection and vaccination, the D2-FLM variant, which is insensitive to antibody-dependent enhancement-prone fusion loop antibodies, also offers potential for a safer dengue virus vaccine.
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    1. Genetics and Genomics
    2. Immunology and Inflammation

    Epigenetic signature of human immune aging in the GESTALT study

    Roshni Roy, Pei-Lun Kuo ... Luigi Ferrucci
    Identification of human DNA sites differentially methylated with aging across six different primary immune cells suggests that the sensing of hypoxia drives the epigenetic clock.
    1. Neuroscience

    Towards a Neurometric-based Construct Validity of Trust

    Pin-Hao A. Chen, Dominic Fareri ... Luke J. Chang
    Not revised
    Reviewed Preprint v1
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    1. Neuroscience

    Get the gist of the story: Neural map of topic keywords in multi-speaker environment

    Hyojin Park, Joachim Gross
    Not revised
    Reviewed Preprint v1
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    1. Neuroscience

    Resting-state fMRI signals contain spectral signatures of local hemodynamic response timing

    Sydney M Bailes, Daniel EP Gomez ... Laura D Lewis
    The frequency content of resting-state fMRI signals contains information that can characterize and predict local variations in hemodynamic response timing which enhances the temporal precision of fMRI.
    1. Evolutionary Biology
    2. Neuroscience

    Broca’s area, variation and taxic diversity in early Homo from Koobi Fora (Kenya)

    Amélie Beaudet, Edwin de Jager
    A computer-assisted revision of a unique fossil from Kenya supports the hypothesis that the modern features of our brain emerged recently in the human evolutionary history.
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    1. Cell Biology

    BATF relieves hepatic steatosis by inhibiting PD1 and promoting energy metabolism

    Zhiwang Zhang, Qichao Liao ... Lei Zhou
    Gene function studies confirmed that the BATF-PD1 axis and BATF-IL27 axis are regulatory factor for lipid accumulation in hepatocytes and adipocytes.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Effects of smoking on genome-wide DNA methylation profiles: A study of discordant and concordant monozygotic twin pairs

    Jenny van Dongen, Gonneke Willemsen ... Michael C Neale
    Analysis of data from monozygotic twins reveals that DNA methylation level in human blood cells is reactive to cigarette smoking.
    1. Microbiology and Infectious Disease

    Biosensor-integrated transposon mutagenesis reveals rv0158 as a coordinator of redox homeostasis in Mycobacterium tuberculosis

    Somnath Shee, Reshma T Veetil ... Amit Singh
    Genome-scale integration of transposon mutagenesis with a redox biosensor identified a hypothetical transcription factor- Rv0158 required to calibrate the growth, cytoplasmic redox potential, and respiration of Mycobacterium tuberculosis in response to metabolic switching from glucose to fatty acids.
    1. Biochemistry and Chemical Biology

    A generic binding pocket for small molecule IKs activators at the extracellular inter-subunit interface of KCNQ1 and KCNE1 channel complexes

    Magnus Chan, Harutyun Sahakyan ... David Fedida
    Characterization of an extra-membrane site in IKs formed by KCNQ1 S1, Pore and S6 domains and the near extracellular region of KCNE1, which forms a binding pocket for channel activators.