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Page 452 of 1,892
    1. Cell Biology

    Surface curvature and basal hydraulic stress induce spatial bias in cell extrusion

    Cheng-Kuang Huang, Xianbin Yong ... Chwee Teck Lim
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Genetics and Genomics

    Leveraging inter-individual transcriptional correlation structure to infer discrete signaling mechanisms across metabolic tissues

    Mingqi Zhou, Ian Tamburini ... Marcus M Seldin
    A population resource to investigate mechanisms of organ communication.
    1. Neuroscience

    Resource-rational account of sequential effects in human prediction

    Arthur Prat-Carrabin, Florent Meyniel, Rava Azeredo da Silveira
    A proposed model of optimal inference under cognitive costs accounts for human sequential effects, including subtle patterns of attractive and repulsive influence of past observations, in a binary prediction task across a wide range of stimulus conditions.
    1. Neuroscience

    Toolkits for detailed and high-throughput interrogation of synapses in C. elegans

    Maryam Majeed, Haejun Han ... Hang Lu
    An imaging pipeline together with a collection of transgenic nematode strains provide a strategy to visualize and properly quantify synaptic connectivity in the C. elegans brain.
    1. Medicine
    2. Neuroscience

    Resting-state alterations in behavioral variant frontotemporal dementia are related to the distribution of monoamine and GABA neurotransmitter systems

    Lisa Hahn, Simon B Eickhoff ... Matthias L Schroeter
    Local brain functional activity reductions in bvFTD follow the distribution of serotonergic, GABAergic, and norepinephrinergic neurotransmitter systems, indicating a selective vulnerability and providing novel insights into the underlying disease mechanisms.
    1. Epidemiology and Global Health

    Design of the HPV-automated visual evaluation (PAVE) study: Validating a novel cervical screening strategy

    Silvia de Sanjosé, Rebecca B Perkins ... Mark Schiffman
    The PAVE strategy aims to provide a cost-effective, high quality ‘Screen-Triage-Treat’ approach for cervical cancer screening to save many lives.
    1. Neuroscience

    EphrinB2 knockdown in cervical spinal cord preserves diaphragm innervation in a mutant SOD1 mouse model of ALS

    Mark W Urban, Brittany A Charsar ... Angelo C Lepore
    In the SOD1G93A mouse model of amyotrophic lateral sclerosis (ALS), expression of transmembrane signaling molecule ephrinB2 in spinal cord astrocytes contributes to motor neuron damage and loss of diaphragm function.
    1. Genetics and Genomics

    Multi-ancestry meta-analysis of host genetic susceptibility to tuberculosis identifies shared genetic architecture

    Haiko Schurz, Vivek Naranbhai ... International Tuberculosis Host Genetics Consortium
    Results from the largest tuberculosis genome-wide association study meta-analysis identified a significant association in the human leukocyte antigen class II region, rs28383206, across multiple populations.
    1. Genetics and Genomics

    A population modification gene drive targeting both Saglin and Lipophorin impairs Plasmodium transmission in Anopheles mosquitoes

    Emily I Green, Etienne Jaouen ... Eric Marois
    Strong reduction in malaria transmission by genetically modified mosquitoes is achieved in the laboratory using a dual gene drive that simultaneously propagates an antiparasitic factor and a parasite-detrimental mosquito mutation.
    1. Developmental Biology

    Neural tube-associated boundary caps are a major source of mural cells in the skin

    Gaspard Gerschenfeld, Fanny Coulpier ... Piotr Topilko
    Neural tube-associated boundary caps are heterogeneous with a non-neural crest-derived subpopulation that may originate from the developing meninges, which gives rise to derivatives that migrate along nerves to detach and differentiate into skin mural cells.