Browse the latest research

Page 453 of 1,892
    1. Neuroscience

    A preclinical model of THC edibles that produces high-dose cannabimimetic responses

    Anthony English, Fleur Uittenbogaard ... Benjamin Bruce Land
    Δ9-Tetrahydrocannabinol (THC)-E-gel enables robust preclinical study of voluntary THC consumption in mice, revealing sex-dependent psychotomimetic effects that are valuable for understanding cannabimimetic responses.
    1. Cell Biology
    2. Physics of Living Systems

    Probe-free optical chromatin deformation and measurement of differential mechanical properties in the nucleus

    Benjamin Seelbinder, Susan Wagner ... Moritz Kreysing
    Localized temperature gradients used as a novel method of active micro-theology that is non-invasive and probe-free, to investigate material responses of cell departments such as the different compartments of a nucleus displaying distinct material properties.
    1. Neuroscience

    Eelbrain, a Python toolkit for time-continuous analysis with temporal response functions

    Christian Brodbeck, Proloy Das ... Jonathan Z Simon
    Brain activity is modelled as a function of stimuli that evolve continuously in time, in experimental designs without repeated trials.
    1. Cancer Biology
    2. Genetics and Genomics

    Single-cell sequencing highlights heterogeneity and malignant progression in actinic keratosis and cutaneous squamous cell carcinoma

    Dan-Dan Zou, Ya-Zhou Sun ... Xin Li
    A single-cell RNA profiling analysis has delineated the molecular changes driving the progression from actinic keratosis to cutaneous squamous cell carcinoma.
    1. Biochemistry and Chemical Biology
    2. Ecology

    Binding and sequestration of poison frog alkaloids by a plasma globulin

    Aurora Alvarez-Buylla, Marie-Therese Fischer ... Lauren A O'Connell
    Alkaloid-binding globulin (ABG) is a novel protein discovered in the plasma of poison frogs that transports many alkaloids, with structural homology to mammalian hormone carriers and amphibian biliverdin-binding serpin.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Activin A marks a novel progenitor cell population during fracture healing and reveals a therapeutic strategy

    Lutian Yao, Jiawei Lu ... Maurizio Pacifici
    Activation of Activin A-expressing progenitor cells emerges as a pivotal mechanism in bone fracture healing, shedding light on a potential therapeutic avenue to augment bone repair processes.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    A Vibrio cholerae viral satellite maximizes its spread and inhibits phage by remodeling hijacked phage coat proteins into small capsids

    Caroline M Boyd, Sundharraman Subramanian ... Kimberley D Seed
    A phage parasite encodes an external scaffolding protein to pirate and rearrange phage-encoded coat proteins to more efficiently transfer the phage parasite genome to new hosts and limit phage production.
    1. Computational and Systems Biology

    Long-read single-cell sequencing reveals expressions of hypermutation clusters of isoforms in human liver cancer cells

    Silvia Liu, Yan-Ping Yu ... Jian-Hua Luo
    A synthetic long-read single-cell sequencing reveals critical mutation isoform expression patterns in human liver cancer cells.
    1. Cell Biology

    Location, location, location: Protein kinase nanoclustering for optimised signalling output

    Rachel S Gormal, Ramon Martinez-Marmol ... Frédéric A Meunier
    This article reviews the latest studies that have used super-resolution microscopy and cluster analysis methodologies to study the mechanism of protein kinase signalling hubs and their organisation at nanoscale.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Comparative analysis of two Caenorhabditis elegans kinesins KLP-6 and UNC-104 reveals a common and distinct activation mechanism in kinesin-3

    Tomoki Kita, Kyoko Chiba ... Shinsuke Niwa
    Comparative biochemical analysis of a nematode-specific kinesin-3 shed light on the mechanism of kinesin-3 dimerization and activation.