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Page 461 of 1,892
    1. Immunology and Inflammation

    The lncRNA Malat1 inhibits miR-15/16 to enhance cytotoxic T cell activation and memory cell formation

    Benjamin D Wheeler, John D Gagnon ... K Mark Ansel
    A single microRNA-binding site in a long non-coding RNA alters T cell responses in vivo by 'sponging' the miRNA to inhibit its gene regulatory function.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Pharmacological inhibition of CLK2 activates YAP by promoting alternative splicing of AMOTL2

    Maya L Bulos, Edyta M Grzelak ... Michael J Bollong
    Screening repurposed drugs identifies that a clinical stage inhibitor splicing related kinases unexpectedly activates YAP driven transcription in cells.
    1. Cell Biology
    2. Immunology and Inflammation

    Regulation of pDC fate determination by histone deacetylase 3

    Yijun Zhang, Tao Wu ... Li Wu
    HDAC3 regulates the development of pDCs and maintenance of homeostasis of hematopoietic progenitors with dendritic cell (DC) differentiation potential, mechanistically by repressing cDC1 associated genes in a deacetylase-dependent manner.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The neuronal calcium sensor NCS-1 regulates the phosphorylation state and activity of the Gα chaperone and GEF Ric-8A

    Daniel Muñoz-Reyes, Levi J McClelland ... Maria Jose Sanchez-Barrena
    Biochemical, biophysical, and structural approach to determine the molecular basis of the calcium-sensitive regulation of the Gα chaperone and guanine exchange factor Ric-8A by the neuronal calcium sensor NCS-1.
    1. Neuroscience

    Myomatrix arrays for high-definition muscle recording

    Bryce Chung, Muneeb Zia ... Samuel J Sober
    A novel technology for recording muscle activity provides unprecedented access to the electrical signals that control the body across muscles, species, and behaviors.
    1. Microbiology and Infectious Disease

    Atlas of Plasmodium falciparum intraerythrocytic development using expansion microscopy

    Benjamin Liffner, Ana Karla Cepeda Diaz ... Sabrina Absalon
    Ultrastructure expansion microscopy unlocks new fundamental cell biology of malaria parasites, providing new insights into processes including establishment of cell polarity, organelle biogenesis, and organelle fission.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Ice nucleation proteins self-assemble into large fibres to trigger freezing at near 0 °C

    Thomas Hansen, Jocelyn Lee ... Peter L Davies
    Self-assembly of bacterial ice nucleation proteins is required for efficient activity and is mediated by electrostatic interactions, creating long and thin fibres.
    1. Developmental Biology
    2. Neuroscience

    Age-associated changes in lineage composition of the enteric nervous system regulate gut health and disease

    Subhash Kulkarni, Monalee Saha ... Pankaj Jay Pasricha
    Mesoderm-derived enteric neurons born in the post-natal vertebrates drive maturation and aging of the enteric nervous system.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Estimating the contribution of subclinical tuberculosis disease to transmission: An individual patient data analysis from prevalence surveys

    Jon C Emery, Peter J Dodd ... Rein MGJ Houben
    Data analysis and mathematical modelling suggest that subclinical tuberculosis contributes substantially to transmission and needs to be diagnosed and treated for effective progress towards tuberculosis elimination.