Benjamin D Wheeler, John D Gagnon ... K Mark Ansel
A single microRNA-binding site in a long non-coding RNA alters T cell responses in vivo by 'sponging' the miRNA to inhibit its gene regulatory function.
Maya L Bulos, Edyta M Grzelak ... Michael J Bollong
Screening repurposed drugs identifies that a clinical stage inhibitor splicing related kinases unexpectedly activates YAP driven transcription in cells.
HDAC3 regulates the development of pDCs and maintenance of homeostasis of hematopoietic progenitors with dendritic cell (DC) differentiation potential, mechanistically by repressing cDC1 associated genes in a deacetylase-dependent manner.
Daniel Muñoz-Reyes, Levi J McClelland ... Maria Jose Sanchez-Barrena
Biochemical, biophysical, and structural approach to determine the molecular basis of the calcium-sensitive regulation of the Gα chaperone and guanine exchange factor Ric-8A by the neuronal calcium sensor NCS-1.
A novel technology for recording muscle activity provides unprecedented access to the electrical signals that control the body across muscles, species, and behaviors.
Benjamin Liffner, Ana Karla Cepeda Diaz ... Sabrina Absalon
Ultrastructure expansion microscopy unlocks new fundamental cell biology of malaria parasites, providing new insights into processes including establishment of cell polarity, organelle biogenesis, and organelle fission.
Self-assembly of bacterial ice nucleation proteins is required for efficient activity and is mediated by electrostatic interactions, creating long and thin fibres.
Data analysis and mathematical modelling suggest that subclinical tuberculosis contributes substantially to transmission and needs to be diagnosed and treated for effective progress towards tuberculosis elimination.