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Full-length single-cell RNA-sequencing provide insights into the earliest gene expression programs, the distinct mRNA transcript isoforms, and the retinoblastoma-related cell states associated with human cone and rod photoreceptor development.

The majority of TMEM16 lipid scrambling occurs in the open groove associated with Ca²⁺ activation, but limited scrambling also occurs in the dimer interface independent of Ca²⁺.

Keratinocyte cytonemes mediate essential Notch signaling for proper skin maintenance, with their disruption leading to abnormal differentiation and hyperproliferation resembling human skin disease phenotypes.

Exercise intensity alone does not differentially reduce pain, but individual factors like fitness level and sex, along with opioid mechanisms, may influence exercise-induced pain relief.

Fine-grained neural dynamics underlying speech coordination are revealed using a real-time interactive synchronous speech task that dissociates functional roles within the dorsal language pathway.

Kallistatin acts as a key regulator in mediating Aβ accumulation and tau hyperphosphorylation in AD.