Structural Biology and Molecular Biophysics

Structural Biology and Molecular Biophysics

eLife reviews research that uses techniques including X-ray crystallography, cryo-EM and single-molecule methods. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Harnessing AlphaFold to reveal hERG channel conformational state secrets

    Khoa Ngo, Pei-Chi Yang ... Igor Vorobyov
    Customized AlphaFold-based modeling of distinct functional states of the hERG channel, a major drug anti-target, significantly improves drug affinity predictions, enhancing cardiac safety screening for arrhythmia risk.
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Polyphosphate discriminates protein conformational ensembles more efficiently than DNA promoting diverse assembly and maturation behaviors

    Saloni Goyal, Divya Rajendran ... Athi N Naganathan
    Polyphosphate, a universal stress response regulator, binds distinctively to different starting ensembles of the same protein leading to either condensates or aggregates that in turn can solubilize or further aggregate, showcasing their ability to finely control the assembly process.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Mechanism of SK2 channel gating and its modulation by the bee toxin apamin and small molecules

    Samantha J Cassell, Weiyan Li ... Jonathan R Whicher
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Atomistic Simulation of Voltage Activation of a Truncated BK Channel

    Zhiguang Jia, Jianhan Chen
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Solid
    1. Structural Biology and Molecular Biophysics

    Structural insights into peptidoglycan hydrolysis by the FtsEX system in Escherichia coli during cell division

    Jianwei Li, Yutong He ... Min Luo
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Solid
    1. Structural Biology and Molecular Biophysics

    A high-resolution analysis of arrestin2 interactions responsible for CCR5 endocytosis

    Ivana Petrovic, Samit Desai ... Stephan Grzesiek
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Structural Biology and Molecular Biophysics

    The molecular infrastructure of glutamatergic synapses in the mammalian forebrain

    Julia Peukes, Charlie Lovatt ... René A Frank
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Evolutionary Biology
    2. Structural Biology and Molecular Biophysics

    Prebiotic gas flow environment enables isothermal nucleic acid replication

    Philipp Schwintek, Emre Eren ... Dieter Braun
    Exponential nucleic acid replication can occur isothermally in a prebiotically plausible setting that accumulates and simultaneously separates the strands of nucleic acids through evaporation-driven flows at the gas–water interface.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Occupancy of the HbYX hydrophobic pocket is sufficient to induce gate opening in the archaeal 20S proteasomes

    Janelle JY Chuah, Madalena R Daugherty, David M Smith
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Structural Biology and Molecular Biophysics

    The C-terminus of the multi-drug efflux pump EmrE prevents proton leak by gating transport

    Merissa Brousseau, Da Teng ... Katherine A Henzler-Wildman
    The C-terminal tail acts as a secondary gate to regulate substrate access into the primary binding site for transport across the membrane.
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Highlights

    1. Structural Biology and Molecular Biophysics
    2. Cell Biology
    3. Biochemistry and Chemical Biology

    Allosteric Regulation of Kinase Activity – call for papers

    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Modelling biomolecular condensates

    Furqan Dar, Rohit Pappu
    1. Structural Biology and Molecular Biophysics

    Same structure, different mechanisms?

    Francis TF Tsai, Christopher P Hill

Senior editors

  1. Felix Campelo
    Pompeu Fabra University, Spain
  2. Volker Dötsch
    Goethe University, Germany
  3. Merritt Maduke
    Stanford University School of Medicine, United States
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