Structural Biology and Molecular Biophysics

Latest articles

1. 1. Structural Biology and Molecular Biophysics

   Structure and Cl^- Conductance Properties of the Open State of Human CFTR

   Zhi-Wei Zeng, Christopher E Ing, Régis Pomès
2. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Drug Discovery: How to exploit the recycling system of a cell

   Sasha L Evans, Bethany A Haynes ... Rivka L Isaacson

   Nature has inspired the design of improved inhibitors for cancer-causing proteins.
3. 1. Structural Biology and Molecular Biophysics

   Wide transition-state ensemble as key component for enzyme catalysis

   Gabriel E Jara, Francesco Pontiggia ... Dorothee Kern

   Computational and experimental evidence shows that the reaction catalyzed by adenylate kinase operates through a broad transition-state ensemble (TSE), utilizing protein conformational diversity to reduce activation entropy.
4. 1. Structural Biology and Molecular Biophysics
   2. Microbiology and Infectious Disease

   Genomic and structural insights into Jyvaskylavirus, the first giant virus isolated from Finland

   Gabriel Magno de Freitas Almeida, Iker Arriaga ... Lotta-Riina Sundberg
5. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   A conformational fingerprint for amyloidogenic light chains

   Cristina Paissoni, Sarita Puri ... Carlo Camilloni
6. 1. Neuroscience
   2. Structural Biology and Molecular Biophysics

   CryoEM structures of Kv1.2 potassium channels, conducting and non-conducting

   Yangyu Wu, Yangyang Yan ... Fred J Sigworth

   The well-studied Kv1.2 potassium ion channel is observed in a variety of states and conditions, to understand mechanisms of ion permeation, gating and block.
7. 1. Structural Biology and Molecular Biophysics

   Mechanism of dimer selectivity and binding cooperativity of BRAF inhibitors

   Joseph Clayton, Aarion Romany ... Jana Shen

   BRAF inhibitors achieve monomer or dimer selectivity through their ability to modulate dimerization and allosteric communication.
8. 1. Structural Biology and Molecular Biophysics
   2. Computational and Systems Biology

   Compound Mutations in the Abl1 Kinase Cause Inhibitor Resistance by Shifting DFG Flip Mechanisms and Relative State Populations

   Gabriel Monteiro da Silva, Kyle Lam ... Brenda M Rubenstein
9. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Structure of METTL3-METTL14 with an m6A nucleotide reveals insights into m6A conversion and sensing

   Shan Qi, Abhay Kumar ... Yogesh K Gupta
10. 1. Structural Biology and Molecular Biophysics

    Flexibility in PAM recognition expands DNA targeting in xCas9

    Kazi A Hossain, Lukasz Nierzwicki ... Giulia Palermo

    xCas9's ability to recognise diverse DNA sequences stems from structural flexibility in the protospacer adjacent motif (PAM)-interacting cleft and adaptability to PAM-induced conformational changes, paving the way for advanced genome editing tools.