Structural Biology and Molecular Biophysics

Structural Biology and Molecular Biophysics

eLife reviews research that uses techniques including X-ray crystallography, cryo-EM and single-molecule methods. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Structural Biology and Molecular Biophysics

    Crosslinking by ZapD drives the assembly of short FtsZ filaments into toroidal structures in solution

    Adrián Merino-Salomón, Jonathan Scheneider ... German Rivas
    Promoting FtsZ toroidal polymer formation by ZapD offers new insights into stabilizing the bacterial division ring.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Mechanism of SK2 channel gating and its modulation by the bee toxin apamin and small molecules

    Samantha J Cassell, Weiyan Li ... Jonathan R Whicher
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Structural Biology and Molecular Biophysics

    Allosteric effects of the coupling cation in melibiose transporter MelB

    Parameswaran Hariharan, Yuqi Shi ... Lan Guan
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Structural Biology and Molecular Biophysics

    In silico design and validation of high-affinity RNA aptamers for SARS-CoV-2 comparable to neutralizing antibodies

    Yanqing Yang, Lulu Qiao ... Ruhong Zhou
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Structural Biology and Molecular Biophysics

    p53 isoforms have a high aggregation propensity, interact with chaperones and lack binding to p53 interaction partners

    Anamari Brdar, Christian Osterburg ... Volker Dötsch
    p53 isoforms induce cellular stress based on their only partially folded states.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Structure-guided loop grafting improves expression and stability of influenza neuraminidase for vaccine development

    Pramila Rijal, Leiyan Wei ... Alain RM Townsend
    Grafting surface loops containing antibody epitopes of a poorly expressed flu neuraminidase protein onto a high-expressing, stable scaffold improves its production and stability for vaccine development.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Atomistic simulation of voltage activation of a truncated BK channel

    Zhiguang Jia, Jianhan Chen
    Ten-microsecond atomistic simulations directly capture the voltage activation of the Core-MT big potassium channel, revealing novel voltage sensing and sensor-pore coupling mechanisms that have largely eluded the community.
    1. Structural Biology and Molecular Biophysics

    Sld3CBD–Cdc45 structural insights into Cdc45 recruitment for CMG complex formation during DNA replication

    Hao Li, Izumi Ishizaki ... Min Yao
    The crystal structure of Sld3CBD-Cdc45 shows its intermolecular interactions, and subsequent Sld3CBD-CMG model construction and binding assays enable a proposal for the mechanism of Cdc45 recruitment and Sld3 release.
    1. Structural Biology and Molecular Biophysics
    2. Physics of Living Systems

    Detecting directed motion and confinement in single-particle trajectories using hidden variables

    François Simon, Guillaume Ramadier ... Lucien E Weiss
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Opening and closing of a cryptic pocket in VP35 toggles it between two different RNA-binding modes

    Upasana L Mallimadugula, Matthew A Cruz ... Gregory R Bowman
    The cryptic pocket is critical for one of the VP35 protein's functions and therefore is likely under selective pressure.
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Highlights

    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Taking a close look at strand exchange

    Akira Shinohara
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology
    3. Biochemistry and Chemical Biology

    Allosteric Regulation of Kinase Activity – call for papers

    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Modelling biomolecular condensates

    Furqan Dar, Rohit Pappu

Senior editors

  1. Amy H Andreotti
    Iowa State University, United States
  2. Qiang Cui
    Boston University, United States
  3. Volker Dötsch
    Goethe University, Germany
  4. See more editors