Structural Biology and Molecular Biophysics

Latest articles

1. 1. Structural Biology and Molecular Biophysics

   Bifunctional architecture enables substrate catalysis and channeling in Paracoccus TMAO demethylase

   Trung Thach, KanagaVijayan Dhanabalan ... Ramaswamy Subramanian

   Trimethylamine N-oxide demethylase uses substrate channeling to couple trimethylamine N-oxide demethylation with one-carbon metabolism, safely detoxifying formaldehyde while enhancing metabolic efficiency.
2. 1. Structural Biology and Molecular Biophysics

   Two Glu/Asp residues cooperatively mediate an early step of ATP hydrolysis in GHKL ATPases MutL and GyrB

   Kenji Fukui, Ayaka Shibuya ... Takato Yano

   A cooperative catalytic mechanism provides a revised framework for understanding ATP hydrolysis in a broad subset of GHKL ATPases.
3. 1. Structural Biology and Molecular Biophysics

   Large scale prospective evaluation of co-folding across hundreds of Mac1-ligand complexes and three virtual screens

   Jongbin Kim, Galen J Correy ... James S Fraser
4. 1. Structural Biology and Molecular Biophysics

   VDAC2 stabilizes a membrane-inserted, primed intermediate of BAX activation

   Varun Ravishankar, Laidy M Alvero-González ... Lucie Bergdoll
5. 1. Structural Biology and Molecular Biophysics
   2. Microbiology and Infectious Disease

   Distinct allosteric remodeling of HIV-1 Env dynamics on virions by gp41-directed antibodies reveals two modes of neutralization

   Wang Xu, Narendra Kumar Gonepudi ... Maolin Lu
6. 1. Structural Biology and Molecular Biophysics

   In extracto cryo-EM reveals eEF2 as a major hibernation factor on 60S and 80S particles

   Zahra Seraj, Ximena Zottig ... Andrei A Korostelev

   Cryogenic electron microscopy of cellular extracts can visualize atomic details and discover new interactions between biological molecules, such as the interactions of the ribosome, the protein-making machinery, with essential proteins to regulate cellular functions.
7. 1. Cell Biology
   2. Structural Biology and Molecular Biophysics

   A biochemical mechanism for Stu2/XMAP215-family microtubule polymerases

   Binnu Gangadharan, Daniel L Kober, Luke M Rice

   Evolutionarily unrelated microtubule and actin regulatory factors use the same mechanism to accelerate polymerization.
8. 1. Structural Biology and Molecular Biophysics

   Characterization of an early-diverging KCNE potassium-channel auxiliary subunit in the jawless vertebrate lamprey

   Go Kasuya, Kaei Ryu ... Koichi Nakajo

   A lamprey KCNE protein provides insight into the early evolution of vertebrate potassium-channel regulation.
9. 1. Structural Biology and Molecular Biophysics

   A membrane insertion code for intrinsically disordered proteins

   Fidha Nazreen Kunnath Muhammedkutty, Huan-Xiang Zhou

   A sequence-based method dubbed AroMIP predicts the membrane insertion propensities of aromatic-centered motifs, thereby advancing mechanistic understanding of membrane insertion and enriching the tools for studying intrinsically disordered protein (IDP)-membrane association.
10. 1. Structural Biology and Molecular Biophysics

    Optimising the tilt increment for in situ cryo-electron tomography

    Maarten Willem Tuijtel, Tomáš Majtner ... Martin Beck

    For in situ cryo-electron tomography, smaller tilt increments yield better-aligned tilt-series and higher-quality tomograms, with a 3° increment resulting in optimal subtomogram averaging resolution.