Structural Biology and Molecular Biophysics

Latest articles

1. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Gβγ engages PLCβ3 at multiple sites to reorient and facilitate its activation

   Isaac J Fisher, Kanishka Senarath ... Angeline M Lyon
2. 1. Structural Biology and Molecular Biophysics

   Structural mechanisms of pump assembly and drug transport in the AcrAB–TolC efflux system

   Xiaofei Ge, Zhiwei Gu, Jiawei Wang
3. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Natural xanthones as α-Mangostin induce vasorelaxation involving key gating residues in the S6 domain of BK channels

   Sönke Cordeiro, Robert Patejdl ... Marianne Musinszki
4. 1. Structural Biology and Molecular Biophysics

   A structural code for assembly specificity in GID/CTLH-type E3 ligases

   Pia Maria van gen Hassend, Hermann Schindelin

   Structural characterization of the CTLH-CRA domain-mediated pairing in the CTLH ubiquitin ligase complex enables rational engineering of interfaces with altered binding specificity.
5. 1. Structural Biology and Molecular Biophysics

   Glycobiology: How enzymes make the right choice during biosynthesis

   Ana S Ramírez, Camilo Perez

   The biosynthesis of an important biopolymer called hyaluronan requires an enzyme that discriminates between two different substrates.
6. 1. Structural Biology and Molecular Biophysics
   2. Cell Biology

   Unbend: Correction of local beam-induced sample motion in cryo-EM images using a 3D spline model

   Lingli Kong, Ximena Zottig ... Nikolaus Grigorieff
7. 1. Physics of Living Systems
   2. Structural Biology and Molecular Biophysics

   Detecting directed motion and confinement in single-particle trajectories using hidden variables

   François Simon, Guillaume Ramadier ... Lucien E Weiss

   Exatrack is a framework for analyzing Brownian, directed, and confined motion using a hidden-variable probabilistic model to extract physical insight into particle diffusion.
8. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Transforming a fragile protein helix into an ultrastable scaffold via a hierarchical AI and chemistry framework

   Jun Qiu, Guojin Tang ... Peng Zheng

   A hierarchical framework integrating artificial intelligence with chemical principles enables the conversion of fragile α-helices into ultrastable protein scaffolds.
9. 1. Structural Biology and Molecular Biophysics

   Membrane Biology: Two binding sites are better than one

   Mackenzie K Scott, John E Burke

   The reasons why two multiprotein complexes – VPS34 complex I and VPS34 complex II – are activated by different Rab proteins are becoming clearer.
10. 1. Structural Biology and Molecular Biophysics

    A novel RAB5 binding site in human VPS34-CII that is likely the primordial site in eukaryotic evolution

    Saulė Špokaitė, Yohei Ohashi ... Roger L Williams