Structural Biology and Molecular Biophysics

Latest articles

1. 1. Structural Biology and Molecular Biophysics

   In-cell cryo-electron tomography reveals differential effects of type I and type II kinase inhibitors on LRRK2 filament formation and microtubule association

   Tamar Basiashvili, Joshua Hutchings ... Elizabeth Villa
2. 1. Structural Biology and Molecular Biophysics

   Conformational variability of HIV-1 Env trimer and viral vulnerability

   Yiwei Cao, Wonpil Im

   Large-scale all-atom simulations of a full-length, glycosylated HIV-1 Env trimer in an asymmetric membrane reveal a rigid ectodomain and highly diverse conformational landscapes in the membrane-proximal region and transmembrane domain.
3. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Structural insights into the recruitment of viral type 2 IRES to ribosomal preinitiation complex for protein synthesis

   Deepakash Das, Tanweer Hussain

   The viral type 2 internal ribosome entry site uses a unique mechanism to hijack the host ribosomal machinery by interacting with initiator tRNA and 40S head.
4. 1. Structural Biology and Molecular Biophysics

   Intraflagellar transport protein IFT172 contains a C-terminal ubiquitin-binding U-box-like domain involved in ciliary signaling

   Nevin K Zacharia, Stefanie Kuhns ... Esben Lorentzen

   The IFT172 C-terminus bridges IFT-A and IFT-B complexes through mutually exclusive interactions with IFT140 and IFT144, and harbors a U-box-like domain linking intraflagellar transport to ubiquitin-dependent ciliary signaling.
5. 1. Structural Biology and Molecular Biophysics

   Optimising the tilt-increment for in situ cryo-electron tomography

   Maarten W Tuijtel, Tomáš Majtner ... Martin Beck
6. 1. Structural Biology and Molecular Biophysics

   In silico design and validation of high-affinity RNA aptamers for SARS-CoV-2 comparable to neutralizing antibodies

   Yanqing Yang, Lulu Qiao ... Ruhong Zhou
7. 1. Structural Biology and Molecular Biophysics

   Improved cryo-EM reconstruction of sub-50 kDa complexes using 2D template matching

   Kexin Zhang, Timothy Grant, Nikolaus Grigorieff
8. 1. Structural Biology and Molecular Biophysics

   Myristoylation licenses disordered viral VP4 protein to anchor to and perforate the membrane through phase separation

   Sichao Huang, Fengzhen Deng ... Bin Sun
9. 1. Structural Biology and Molecular Biophysics
   2. Microbiology and Infectious Disease

   RNA Selectively Modulates Activity of Virulent Amyloid PSMα3 and Host Defense LL-37 via Phase Separation and Aggregation Dynamics

   Bader Rayan, Eilon Barnea ... Meytal Landau
10. 1. Structural Biology and Molecular Biophysics

    Characterization and modulation of human insulin degrading enzyme conformational dynamics to control enzyme activity

    Jordan M Mancl, Wenguang G Liang ... Wei-Jen Tang

    Integrative structural analysis identifies the structural basis and key residues responsible for IDE conformational dynamics that control the unfolding and selective degradation of amyloid peptides.