Structural Biology and Molecular Biophysics

Structural Biology and Molecular Biophysics

eLife reviews research that uses techniques including X-ray crystallography, cryo-EM and single-molecule methods. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A proteome-wide biochemical screen defines binding determinants of the core autophagy protein LC3B

    Jennifer Kosmatka, Cong Liu ... Amy E Keating
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Phosphorylation and pocket-binding ligands rewire the coupled networks in multidomain protein condensate

    Yu Cao, Jinyu Chen, Xiakun Chu
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Structural Biology and Molecular Biophysics

    Large-scale prospective evaluation of co-folding across hundreds of Mac1–ligand complexes and three virtual screens

    Jongbin Kim, Galen J Correy ... James S Fraser
    Co-folding methods accurately place and rank ligands within an optimization series, yet fail to separate true binders from docking false positives, suggesting complementary roles in drug discovery.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Product-stabilized filamentation by human glutamine synthetase allosterically tunes metabolic activity

    Eric Greene, Richard Muniz ... James S Fraser
    Glutamine drives its own synthetase to assemble into inhibitory filaments, linking product concentration directly to a conformational switch that gates the active site.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Structures of LolB bound to LolA or lipoprotein resolve the final steps of bacterial lipoprotein trafficking

    Abigail E Jepson, Elise Kaplan ... Vassilis Koronakis
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    • Incomplete
    1. Structural Biology and Molecular Biophysics

    On the Polymorph-Selection Determinants of α-Synuclein Amyloid Fibrils Studied at Atomic Resolution

    Lukas Frey, David Rhyner ... Jason Greenwald
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Distinct allosteric remodeling of HIV-1 Env dynamics on virions by gp41-directed antibodies reveals two modes of neutralization

    Wang Xu, Narendra Kumar Gonepudi ... Maolin Lu
    Antibodies can target multiple conformational states of the HIV envelope to block viral entry, broadening the mechanisms underlying neutralization.
    1. Structural Biology and Molecular Biophysics
    2. Physics of Living Systems

    Thermodynamic principles of enzymatic regulation in biomolecular condensates from reaction-coupled molecular modeling

    Enrico Lavagna, Francesco Delfino ... Alessandro Barducci
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    From static structures to dynamic landscapes: cryo-EM redefines RNA biology

    Shekhar Jadhav, Spandan Saha ... Marco Marcia
    Not revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Gβγ engages PLCβ3 at multiple sites to reorient and facilitate its activation

    Isaac J Fisher, Kanishka Senarath ... Angeline M Lyon
    Phospholipase Cβ3 is translocated and activated by the heterotrimeric G protein subunit Gαq at the plasma membrane, but the Gβγ heterodimer is required for maximum activation.
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Highlights

    1. Structural Biology and Molecular Biophysics

    Glycobiology: How enzymes make the right choice during biosynthesis

    Ana S Ramírez, Camilo Perez
    1. Structural Biology and Molecular Biophysics

    Membrane Biology: Two binding sites are better than one

    Mackenzie K Scott, John E Burke
    1. Structural Biology and Molecular Biophysics

    Membrane Proteins: A missing link for efflux pumps

    Hilal Wehbi, Isabelle Broutin

Senior editors

  1. Qiang Cui
    Boston University, United States
  2. Merritt Maduke
    Stanford University School of Medicine, United States
  3. Kenton J Swartz
    National Institute of Neurological Disorders and Stroke, NIH, United States
  4. See more editors