Structural Biology and Molecular Biophysics

Structural Biology and Molecular Biophysics

eLife reviews research that uses techniques including X-ray crystallography, cryo-EM and single-molecule methods. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Structural Biology and Molecular Biophysics

    Domain Coupling in Allosteric Regulation of SthK Measured Using Time-Resolved Transition Metal Ion FRET

    Pierce Eggan, Sharona E Gordon, William N Zagotta
    Not revised
    Reviewed Preprint v1
    • Useful
    • Compelling
    1. Structural Biology and Molecular Biophysics

    AACDB: Antigen-Antibody Complex Database — a Comprehensive Database Unlocking Insights into Interaction Interface

    Yuwei Zhou, Wenwen Liu ... Jian Huang
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Solid
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Shifting the PPARγ conformational ensemble towards a transcriptionally repressive state improves covalent inhibitor efficacy

    Liudmyla Arifova, Brian S MacTavish ... Douglas J Kojetin
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    A Kv2 inhibitor combination reveals native neuronal conductances consistent with Kv2/KvS heteromers

    Robert G Stewart, Matthew James Marquis ... Jon T Sack
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Structural Biology and Molecular Biophysics

    Protein Language Model Identifies Disordered, Conserved Motifs Driving Phase Separation

    Yumeng Zhang, Jared Zheng, Bin Zhang
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Compelling
    1. Structural Biology and Molecular Biophysics

    ATP-release pannexin channels are gated by lysophospholipids

    Erik Henze, Russell N Burkhardt ... Toshimitsu Kawate
    Lysophospholipids directly and reversibly activate pannexin channels, triggering the release of signaling molecules critical for inflammation.
    1. Structural Biology and Molecular Biophysics

    Hidden GPCR structural transitions addressed by multiple walker supervised molecular dynamics (mwSuMD)

    Giuseppe Deganutti, Ludovico Pipito ... Christopher Arthur Reynolds
    Multiple walker supervised molecular dynamics simulations deliver insights on glucagon-like peptide 1 receptor activation, Gs protein binding, and guanosine diphosphate release from the Gsα subunit using an adaptive sampling approach.
    1. Structural Biology and Molecular Biophysics

    Engineering cardiolipin binding to an artificial membrane protein reveals determinants for lipid-mediated stabilization

    Mia L Abramsson, Robin A Corey ... Michael Landreh
    Bulding a cardiolipin binding site into a computationally designed transmembrane protein uncovers how proteins can recognize specific lipids and use them to regulate their function.
    1. Structural Biology and Molecular Biophysics

    Structural and Dynamic Impacts of Single-atom Disruptions to Guide RNA Interactions within the Recognition Lobe of Geobacillus stearothermophilus Cas9

    Helen B Belato, Alexa L Knight ... George P Lisi
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Convincing
    1. Structural Biology and Molecular Biophysics

    LC8 enhances 53BP1 foci through heterogeneous bridging of 53BP1 oligomers

    Jesse Howe, Douglas Walker ... Elisar J Barbar
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Highlights

    1. Structural Biology and Molecular Biophysics
    2. Cell Biology
    3. Biochemistry and Chemical Biology

    Allosteric Regulation of Kinase Activity – call for papers

    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Modelling biomolecular condensates

    Furqan Dar, Rohit Pappu
    1. Structural Biology and Molecular Biophysics

    Same structure, different mechanisms?

    Francis TF Tsai, Christopher P Hill

Senior editors

  1. Felix Campelo
    The Institute of Photonic Sciences, Spain
  2. Qiang Cui
    Boston University, United States
  3. Volker Dötsch
    Goethe University, Germany
  4. See more editors