Structural Biology and Molecular Biophysics

Structural Biology and Molecular Biophysics

eLife reviews research that uses techniques including X-ray crystallography, cryo-EM and single-molecule methods. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Structural Biology and Molecular Biophysics

    Single-Molecule Nanopore Profiling of p53-TAD’s Conformational Dynamics, Interactions, and Inhibition

    David DeCoeur, Samantha Schultz ... Min Chen
    Not revised
    Reviewed Preprint v1
    • Useful
    • Compelling
    • Incomplete
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Cryo-electron tomography sheds light on the largest protein in the Trypanosoma brucei tripartite attachment complex

    Irina Bregy, Robin Benjamin Eberle ... Torsten Ochsenreiter
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Structural Biology and Molecular Biophysics
    2. Evolutionary Biology

    Lipid-Driven Biophysical Selection of β-Furanoside-5’-Phosphate as the Sole Scaffold of Extant RNA

    Ze-Run Zhao, Qian-Qian Chen ... Xiao Wang
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Structural Biology and Molecular Biophysics

    Yoda molecules agonize PIEZO2

    Tharaka D Wijerathne, Aneesh Chandrasekharan ... Jérôme J Lacroix
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Structural Biology and Molecular Biophysics

    Structural insights into peptidoglycan hydrolysis by the FtsEX system in Escherichia coli during cell division

    Jianwei Li, Yutong He ... Min Luo
    Structural and biochemical analyses reveal how E. coli FtsEX accommodates EnvC asymmetry to regulate amidase activation during bacterial cell division.
    1. Structural Biology and Molecular Biophysics

    Improved cryo-EM reconstruction of sub-50 kDa complexes using 2D template matching

    Kexin Zhang, Timothy Grant, Nikolaus Grigorieff
    High-resolution structural information can be recovered from proteins well below the conventional cryo-electron microscopy size range, substantially extending the range of complexes accessible to structural analysis.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Synaptic Organization of Surface AMPARs Changes by Brain Region and Tauopathy

    Rohit M Vaidya, Jiahao Zhang ... Paul R Selvin
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A Sterol-Binding Cavity Underlies Sterol Recognition and Differential Activation of the ABCG5/G8

    Fatemeh Rezaei, Isra F Omar ... Jyh-Yeuan Lee
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A proteome-wide biochemical screen defines binding determinants of the core autophagy protein LC3B

    Jennifer Kosmatka, Cong Liu ... Amy E Keating
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Phosphorylation and pocket-binding ligands rewire the coupled networks in multidomain protein condensate

    Yu Cao, Jinyu Chen, Xiakun Chu
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
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Highlights

    1. Structural Biology and Molecular Biophysics

    Glycobiology: How enzymes make the right choice during biosynthesis

    Ana S Ramírez, Camilo Perez
    1. Structural Biology and Molecular Biophysics

    Membrane Biology: Two binding sites are better than one

    Mackenzie K Scott, John E Burke
    1. Structural Biology and Molecular Biophysics

    Membrane Proteins: A missing link for efflux pumps

    Hilal Wehbi, Isabelle Broutin

Senior editors

  1. Amy H Andreotti
    Iowa State University, United States
  2. Felix Campelo
    Pompeu Fabra University, Spain
  3. Qiang Cui
    Boston University, United States
  4. See more editors