Structural Biology and Molecular Biophysics

Structural Biology and Molecular Biophysics

eLife reviews research that uses techniques including X-ray crystallography, cryo-EM and single-molecule methods. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Evolution of a fuzzy ribonucleoprotein complex in viral assembly

    Huaying Zhao, Tiansheng Li ... Peter Schuck
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Structural Biology and Molecular Biophysics

    Active regulation of the epidermal growth factor receptor by the membrane bilayer

    Shwetha Srinivasan, Xingcheng Lin ... Gabriela S Schlau-Cohen
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Structural Biology and Molecular Biophysics

    Dynamic Architecture of Mycobacterial Outer Membranes Revealed by All-Atom Simulations

    Turner P Brown, Matthieu Chavent, Wonpil Im
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Structural Biology and Molecular Biophysics

    Conduction pathway for potassium through the E. coli pump KdpFABC

    Adel Hussein, Xihui Zhang ... David L Stokes
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    • Solid
    1. Structural Biology and Molecular Biophysics

    DIRseq as a method for predicting drug-interacting residues of intrinsically disordered proteins from sequences

    Matt MacAinsh, Sanbo Qin, Huan-Xiang Zhou
    A sequence-based method, DIRseq, has been developed to predict drug-interacting residues of intrinsically disordered proteins.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Pleomorphic effects of three small-molecule inhibitors on transcription elongation by Mycobacterium tuberculosis RNA polymerase

    Omar Herrera-Asmat, Alexander B Tong ... Carlos Bustamante
    1. Structural Biology and Molecular Biophysics

    Protein-Induced Membrane Strain Drives Supercomplex Formation

    Maximilian C Pöverlein, Alexander Jussupow ... Ville RI Kaila
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Structural Biology and Molecular Biophysics

    Ω-Loop mutations control dynamics of the active site by modulating the hydrogen-bonding network in PDC-3 β-lactamase

    Shuang Chen, Andrew R Mack ... Shozeb Haider
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Product-stabilized filamentation by human glutamine synthetase allosterically tunes metabolic activity

    Eric Greene, Richard Muniz ... James S Fraser
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    The molecular infrastructure of glutamatergic synapses in the mammalian forebrain

    Julia Peukes, Charlie Lovatt ... René AW Frank
    CryoCLEM-guided cryoET of Psd95-GFP knockin mouse tissue and ultra-fresh synaptonerosomes indicate that the postsynaptic density is a not a conserved feature of glutamatergic synapses in the mouse brain.
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Highlights

    1. Structural Biology and Molecular Biophysics

    Enzyme dynamics revealed

    Álvaro de la Gándara, Agnieszka A Kendrick
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology
    3. Biochemistry and Chemical Biology

    Allosteric Regulation of Kinase Activity – call for papers

    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Modelling biomolecular condensates

    Furqan Dar, Rohit Pappu

Senior editors

  1. Amy H Andreotti
    Iowa State University, United States
  2. Volker Dötsch
    Goethe University, Germany
  3. Kenton J Swartz
    National Institute of Neurological Disorders and Stroke, NIH, United States
  4. See more editors