Structural Biology and Molecular Biophysics

Latest articles

1. 1. Structural Biology and Molecular Biophysics

   Predicting the Sequence-Dependent Backbone Dynamics of Intrinsically Disordered Proteins

   Sanbo Qin, Huan-Xiang Zhou
2. 1. Structural Biology and Molecular Biophysics
   2. Cell Biology

   Molecular mapping and functional validation of GLP-1R cholesterol binding sites in pancreatic beta cells

   Affiong I Oqua, Kin Chao ... Alejandra Tomas
3. 1. Structural Biology and Molecular Biophysics

   PUFA stabilizes a conductive state of the selectivity filter in IKs channels

   Alessia Golluscio, Jodene Eldstrom ... H Peter Larsson
4. 1. Structural Biology and Molecular Biophysics

   PPI-hotspot^ID for detecting protein–protein interaction hot spots from the free protein structure

   Yao Chi Chen, Karen Sargsyan ... Carmay Lim

   PPI-hotspot^ID, trained using an automated machine-learning framework, AutoGluon, on the largest PPI-hot spot dataset to date, detects hot spots beyond protein–protein interfaces, uncovering druggable interactions to aid design of PPI-modulating therapeutics.
5. 1. Structural Biology and Molecular Biophysics

   Cryo-EM structure of the CBC-ALYREF complex

   Bradley P Clarke, Alexia E Angelos ... Yi Ren

   Structural studies reveal the mechanism by which the mRNA nuclear export machinery engages with nascent transcripts through interaction with the cap binding complex.
6. 1. Structural Biology and Molecular Biophysics

   Exploring protein structural ensembles: Integration of sparse experimental data from electron paramagnetic resonance spectroscopy with molecular modeling methods

   Julia Belyaeva, Matthias Elgeti

   Complementing experimental data from EPR spectroscopy with computational modeling techniques provides access to protein structural dynamics and enables the characterization of rare protein conformations.
7. 1. Structural Biology and Molecular Biophysics

   N-acetylation of α-synuclein enhances synaptic vesicle clustering mediated by α-synuclein and lysophosphatidylcholine

   Chuchu Wang, Chunyu Zhao ... Cong Liu
8. 1. Cancer Biology
   2. Structural Biology and Molecular Biophysics

   Conserved regulatory motifs in the juxtamembrane domain and kinase N-lobe revealed through deep mutational scanning of the MET receptor tyrosine kinase domain

   Gabriella O Estevam, Edmond M Linossi ... James S Fraser

   Deep mutational scanning reveals interactions in the MET kinase domain that are critical for regulation and cancer-related signaling.
9. 1. Structural Biology and Molecular Biophysics

   Revealing a hidden conducting state by manipulating the intracellular domains in K_V10.1 exposes the coupling between two gating mechanisms

   Reham Abdelaziz, Adam P Tomczak ... Luis A Pardo

   The phenotype of mutant potassium channels described here allows the mechanistic dissection of the complex process of potassium channel gating in the pathology-relevant KCNH family.
10. 1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Cryo-electron tomography reveals the microtubule-bound form of inactive LRRK2

    Siyu Chen, Tamar Basiashvili ... Elizabeth Villa