Structural Biology and Molecular Biophysics

Latest articles

1. 1. Structural Biology and Molecular Biophysics

   Cryo-electron tomographic investigation of native hippocampal glutamatergic synapses

   Aya Matsui, Cathy J Spangler ... Eric Gouaux
2. 1. Structural Biology and Molecular Biophysics

   Cryo-EM structures of Kv1.2 potassium channels, conducting and non-conducting

   Yangyu Wu, Yangyang Yan ... Fred J Sigworth
3. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Isobaric crosslinking mass spectrometry technology for studying conformational and structural changes in proteins and complexes

   Jie Luo, Jeff Ranish
4. 1. Structural Biology and Molecular Biophysics

   PUFA stabilizes a conductive state of the selectivity filter in IKs channels

   Alessia Golluscio, Jodene Eldstrom ... H Peter Larsson
5. 1. Structural Biology and Molecular Biophysics
   2. Cell Biology

   Molecular mapping and functional validation of GLP-1R cholesterol binding sites in pancreatic beta cells

   Affiong I Oqua, Kin Chao ... Alejandra Tomas
6. 1. Structural Biology and Molecular Biophysics

   Predicting the Sequence-Dependent Backbone Dynamics of Intrinsically Disordered Proteins

   Sanbo Qin, Huan-Xiang Zhou
7. 1. Structural Biology and Molecular Biophysics

   PPI-hotspot^ID for detecting protein–protein interaction hot spots from the free protein structure

   Yao Chi Chen, Karen Sargsyan ... Carmay Lim

   PPI-hotspot^ID, trained using an automated machine-learning framework, AutoGluon, on the largest PPI-hot spot dataset to date, detects hot spots beyond protein–protein interfaces, uncovering druggable interactions to aid design of PPI-modulating therapeutics.
8. 1. Structural Biology and Molecular Biophysics

   Cryo-EM structure of the CBC-ALYREF complex

   Bradley P Clarke, Alexia E Angelos ... Yi Ren

   Structural studies reveal the mechanism by which the mRNA nuclear export machinery engages with nascent transcripts through interaction with the cap binding complex.
9. 1. Structural Biology and Molecular Biophysics

   Exploring protein structural ensembles: Integration of sparse experimental data from electron paramagnetic resonance spectroscopy with molecular modeling methods

   Julia Belyaeva, Matthias Elgeti

   Complementing experimental data from EPR spectroscopy with computational modeling techniques provides access to protein structural dynamics and enables the characterization of rare protein conformations.
10. 1. Structural Biology and Molecular Biophysics

    N-acetylation of α-synuclein enhances synaptic vesicle clustering mediated by α-synuclein and lysophosphatidylcholine

    Chuchu Wang, Chunyu Zhao ... Cong Liu