Cell Biology

Latest articles

1. 1. Cell Biology

   Hepatic Transthyretin knockdown alleviates NAFLD by enhancing SERCA2 function and inhibiting endoplasmic reticulum stress

   Yingzi He, Tian Yang ... Fenping Zheng
2. 1. Cell Biology
   2. Immunology and Inflammation

   Extracellular matrices regulate extravasation journey of leukocytes and inflammatory tissue fate

   Yu-Tung Li

   A holistic narrative describes how extracellular matrices regulate various aspects of the entire leukocyte journey from blood to inflamed tissue, and the subsequent functional impacts on leukocyte and tissue fates.
3. 1. Cell Biology

   Dominant spinal muscular atrophy linked mutations in the cargo binding domain of BICD2 result in altered interactomes and dynein hyperactivity

   Hannah Neiswender, Jessica E Pride ... Graydon B Gonsalvez

   Disease-associated mutations in BICD2 result in loss- and gain-of-function interactions and dynein hyperactivity.
4. 1. Cell Biology

   Acidocalcisome-like vacuoles constitute a feedback-controlled phosphate buffering system for the cytosol

   Samuel Bru, Lydie Michaillat Mayer ... Andreas Mayer

   In vitro reconstitution identifies how lysosome-related vacuoles coordinate the synthesis and turnover of inorganic polyphosphates to create a powerful buffer system stabilising a vital metabolic parameter, the cytosolic concentration of phosphate.
5. 1. Cell Biology

   Chemotherapy resistance due to epithelial-to-mesenchymal transition is caused by abnormal lipid metabolic balance

   Atsushi Matsumoto, Akihito Inoko ... Junichi Ikenouchi
6. 1. Cancer Biology
   2. Cell Biology

   Human RAP2A homolog of the Drosophila asymmetric cell division regulator Rap2l targets the stemness of glioblastoma stem cells

   Maribel Franco, Ricardo Gargini ... Ana Carmena

   Restitution of RAP2A, human homolog of Drosophila asymmetric cell division regulator Rap2l, in glioblastoma neurosphere cultures targets the stemness of glioblastoma stem cells and could contribute to reduce glioblastoma expansion.
7. 1. Cell Biology

   SMC5/6-mediated plasmid silencing is directed by SIMC1–SLF2 and antagonized by the SV40 large T antigen

   Martina Oravcová, Minghua Nie ... Michael N Boddy

   Distinct SMC5/6 subcomplexes mediate the transcriptional silencing of circular extrachromosomal DNA (SIMC1–SLF2) and repair of chromosomal DNA lesions (SLF1–SLF2), thus enabling exploration of SMC5/6 functions in innate immunity and cancer.
8. 1. Cell Biology

   The RAB27A effector SYTL5 regulates mitophagy and mitochondrial metabolism

   Ana Lapão, Lauren Sophie Johnson ... Anne Simonsen

   RAB27A-dependent mitochondrial recruitment of SYTL5 promotes mitophagy and mitochondrial bioenergetics upon hypoxia.
9. 1. Cell Biology

   Specific proteolysis mediated by a p97-directed proteolysis-targeting chimera (PROTAC)

   Constanza Salinas-Rebolledo, Javier Blesa ... Alejandro Rojas-Fernandez
10. 1. Cell Biology

    Human dynein-dynactin is a fast processive motor in living cells

    Vikash Verma, Patricia Wadsworth, Thomas J Maresca