Computational and Systems Biology

Latest articles

1. 1. Neuroscience
   2. Computational and Systems Biology

   High performance sorting of motor unit action potentials with EMUsort

   Sean O’Connell, Jonathan A Michaels ... Chethan Pandarinath
2. 1. Computational and Systems Biology
   2. Neuroscience

   Self-association enhances early attentional selection through automatic prioritization of socially salient signals

   Meike Scheller, Jan Tünnermann ... Jie Sui

   Self-related information automatically modulates early attentional selection into awareness through mechanisms distinct from physical salience, revealing an obligatory, individualized self-prioritization at the gateway to perception.
3. 1. Computational and Systems Biology
   2. Genetics and Genomics

   Human-specific lncRNAs contributed critically to human evolution by distinctly regulating gene expression

   Jie Lin, Yujian Wen ... Hao Zhu

   Compared with human-specific transcriptional factors, human-specific lncRNAs identified upon human lncRNAs’ orthologs in mammals have greatly evolved DNA-binding sites in archaic and modern humans in genes determining human traits.
4. 1. Computational and Systems Biology

   Thymic selection of the T cell receptor repertoire is biased toward autoimmunity in females

   Hélène Vantomme, Valentin Quiniou ... David Klatzmann
5. 1. Computational and Systems Biology
   2. Physics of Living Systems

   A Coma Pattern-Based Autofocusing Method Resolves Bacterial Cold Shock Response at Single-Cell Level

   Sihong Li, Zhixin Ma ... Shuqiang Huang
6. 1. Computational and Systems Biology
   2. Genetics and Genomics

   Cell type-specific network analysis in Diversity Outbred mice identifies genes potentially responsible for human bone mineral density GWAS associations

   Luke J Dillard, Gina Calabrese ... Charles Farber

   Single-cell transcriptomics data from mouse bone-relevant cells was used to inform human bone mineral density genome-wide association studies and prioritize genetic targets with potential causal roles in the development of osteoporosis.
7. 1. Neuroscience
   2. Computational and Systems Biology

   Miniscope Processing Suite (MPS): An Intuitive, No-Code, Scalable Pipeline for Long-Duration Calcium Imaging

   Ari Peden-Asarch, Meredith Weinstock ... John F Neumaier
8. 1. Computational and Systems Biology
   2. Microbiology and Infectious Disease

   Automated genome mining predicts structural diversity and taxonomic distribution of peptide metallophores across bacteria

   Zachary L Reitz, Bita Pourmohsenin ... Marnix H Medema

   Automated detection of metallophore biosynthesis reveals that metal-chelating non-ribosomal peptides are widespread, chemically diverse, and deeply rooted in bacterial evolution.
9. 1. Computational and Systems Biology
   2. Evolutionary Biology

   An interpretable neural network unveils higher-order epistasis in large protein sequence-function relationships

   Palash Sethi, Juannan Zhou
10. 1. Computational and Systems Biology

    Deep learning linking mechanistic models to single-cell transcriptomics data reveals transcriptional bursting in response to DNA damage

    Zhiwei Huang, Songhao Luo ... Jiajun Zhang

    DNA damage reshapes genome-wide transcriptional bursting, with distinct burst size and frequency programs associated with differentiation, apoptosis, and survival decisions.