Computational and Systems Biology

Computational and Systems Biology

eLife reviews research involving the use of methods, models and software. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Computational and Systems Biology

    Learning sequence-function relationships with scalable, interpretable Gaussian processes

    Juannan Zhou, Carlos Martí-Gómez ... David M McCandlish
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Computational and Systems Biology

    TSvelo: Comprehensive RNA velocity by modeling the cascade of gene regulation, transcription and splicing

    Jiachen Li, Zhe Wang ... Ye Yuan
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Computational and Systems Biology

    Nonlinear transcriptional responses to gradual modulation of transcription factor dosage

    Júlia Domingo, Mariia Minaeva ... Tuuli Lappalainen
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience
    2. Computational and Systems Biology

    Alpha rhythm subharmonics underlie responsiveness to theta burst stimulation via calcium metaplasticity

    Kevin Kadak, Davide Momi ... John D Griffiths
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Computational and Systems Biology

    Knock-down of a regulatory barcode shifts macrophage polarization destination from M1 to M2 and increases pathogen burden upon S. aureus infection

    Sathyabaarathi Ravichandran, Bharat Bhatt ... Nagasuma Chandra
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Neuroscience
    2. Computational and Systems Biology

    Morphogenesis and morphometry of brain folding patterns across species

    Sifan Yin, Chunzi Liu ... L Mahadevan
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience
    2. Computational and Systems Biology

    Computational modelling identifies key determinants of subregion-specific dopamine dynamics in the striatum

    Aske L Ejdrup, Jakob K Dreyer ... Ulrik Gether
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    • Solid
    1. Neuroscience
    2. Computational and Systems Biology

    Reconstructing Voice Identity from Noninvasive Auditory Cortex Recordings

    Charly Lamothe, Etienne Thoret ... Pascal Belin
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Computational and Systems Biology

    Martinize2 and Vermouth provide a unified framework for molecular topology generation

    Peter C Kroon, Fabian Grünewald ... Siewert J Marrink
    Enabling high-throughput simulations of proteins within the Martini framework.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Identification and classification of ion-channels across the tree of life provide functional insights into understudied CALHM channels

    Rahil Taujale, Sung Jin Park ... Natarajan Kannan
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
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Highlights

    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology
    3. Genetics and Genomics

    Submit to our latest special issue in systems genetics

    1. Cancer Biology
    2. Computational and Systems Biology

    eLife publishes final papers from the Reproducibility Project: Cancer Biology

    Timothy M Errington, Maya Mathur ... Brian A Nosek
    1. Computational and Systems Biology

    International aspects of bioRxiv preprints

    Richard J Abdill, Elizabeth M Adamowicz, Ran Blekhman

Senior editors

  1. Alan Moses
    University of Toronto, Canada
  2. Aleksandra Walczak
    Ecole Normale Superieure, France
  3. See more editors