Computational and Systems Biology

Latest articles

1. 1. Computational and Systems Biology

   Role of desolvation on biomolecular liquid-liquid phase separation

   Kai Zhang, Zhiyu Peng ... Wei Wang
2. 1. Genetics and Genomics
   2. Computational and Systems Biology

   Imputation of structural variants using a multi-ancestry long-read sequencing panel enables identification of disease associations

   Boris Noyvert, A Mesut Erzurumluoglu ... Zhihao Ding
3. 1. Computational and Systems Biology
   2. Immunology and Inflammation

   Linear antibody epitope prediction using AlphaFold2

   Jacob DeRoo, James S Terry ... Brian J Geiss

   AlphaFold2 can be used to accurately determine linear epitopes of antibodies with known heavy and light chain sequences.
4. 1. Cell Biology
   2. Computational and Systems Biology

   Philosophy of Biology: The power of theory in the life sciences

   Jacob L Fine, Finn Creeggan ... Adam MR Groh

   Theory can help address cell and molecular biology’s major challenges, particularly those arising from large omics datasets.
5. 1. Computational and Systems Biology

   Predicting dynamic expression patterns in budding yeast with a fungal DNA language model

   Kuan-Hao Chao, Majed Mohamed Magzoub ... David R Kelley
6. 1. Computational and Systems Biology

   Comprehensive RNA velocity by modeling the cascade of gene regulation, transcription, and splicing from single-cell RNA sequencing data with TSvelo

   Jiachen Li, Zhe Wang ... Ye Yuan

   TSvelo provides a comprehensive RNA velocity mathematics framework that can model the cascade of gene regulation, transcription, and splicing.
7. 1. Microbiology and Infectious Disease
   2. Computational and Systems Biology

   A new diagnostic modality for bovine tuberculosis: accurate and robust classification of infected cattle using transcriptomics and machine learning

   John F O’Grady, Adriana Ivich ... David E MacHugh
8. 1. Immunology and Inflammation
   2. Computational and Systems Biology

   A predictive systems vaccinology framework enables rational optimization of MVA-based vaccines

   Vincent Deman, Philippe Castera ... Anne-Sophie Beignon
9. 1. Computational and Systems Biology
   2. Immunology and Inflammation

   +Clonal stochasticity in early NK cell response to mouse cytomegalovirus is generated by mature subsets of varying proliferative ability

   Darren Wethington, Saeed Ahmad ... Jayajit Das

   Stochastic fluctuations play an important role in the MCMV-induced NK cell clonal expansion that ultimately gives rise to memory NK cells.
10. 1. Computational and Systems Biology

    A real-time, multi-animal model for automatic face detection and identification of freely moving common marmosets based on YOLOv8 algorithms

    Jiayue Yang, James Wang, Justine Cléry