Computational and Systems Biology

Latest articles

1. 1. Medicine
   2. Computational and Systems Biology

   Global molecular landscape of early MASLD progression in obesity

   Qing Zhao, William De Nardo ... Philipp Kaldis
2. 1. Neuroscience
   2. Computational and Systems Biology

   Opposite and complementary roles of the two calcium thresholds for inducing LTP and LTD in models of striatal projection neurons

   Daniel Trpevski
3. 1. Computational and Systems Biology
   2. Neuroscience

   Motor biases reflect a misalignment between visual and proprioceptive reference frames

   Tianhe Wang, J Ryan Morehead ... Jonathan S Tsay

   The pattern of reaching biases is stable across contexts and can be attributed to a misalignment between eye-centric and body-centric representations of position.
4. 1. Computational and Systems Biology

   Single-mRNA imaging and modeling reveal coupled translation initiation and elongation rates

   Irene Lamberti, Jeffrey A Chao ... Felix Naef
5. 1. Computational and Systems Biology

   Ribosome demand links transcriptional bursts to protein expression noise

   Sampriti Pal, Upasana Ray, Riddhiman Dhar

   Propagation of expression noise from mRNA to protein level is influenced by variation in availability of ribosomal machinery.
6. 1. Computational and Systems Biology
   2. Neuroscience

   Deep neural networks to register and annotate cells in moving and deforming nervous systems

   Adam A Atanas, Alicia Kun-Yang Lu ... Steven W Flavell

   New machine vision tools are used to align densely packed cells recorded from live, deforming tissues and automatically annotate the identities of the recorded cell types.
7. 1. Computational and Systems Biology
   2. Neuroscience

   Linking spinal circuit reorganization to recovery after thoracic spinal cord injury

   Natalia A Shevtsova, Andrew B Lockhart ... Simon M Danner

   A computational model mechanistically links spinal circuit reorganization to recovered locomotion after incomplete spinal cord injury.
8. 1. Neuroscience
   2. Computational and Systems Biology

   Gait transition mechanism from quadrupedal to bipedal locomotion in the Japanese macaque based on inverted pendulum

   Koki Nishizaki, Mau Adachi ... Shinya Aoi
9. 1. Computational and Systems Biology
   2. Cancer Biology

   End-to-end proteogenomics for discovery of cryptic and non-canonical cancer proteoforms using long-read transcriptomics and multi-dimensional proteomics

   Katarzyna Kulej, Asher Preska Steinberg ... Alex Kentsis
10. 1. Cancer Biology
    2. Computational and Systems Biology

    Single-cell atlas of AML reveals age-related gene regulatory networks in t(8;21) AML

    Jessica Whittle, Stefan Meyer ... Mudassar Iqbal

    A comprehensive single-cell atlas of AML uncovers regulatory networks and age-dependent molecular differences to advance the understanding of disease mechanisms and enable subtype-specific therapeutic strategies.