Chromosomes and Gene Expression

Latest articles

1. 1. Chromosomes and Gene Expression

   The chromatin remodeller CHD4 regulates transcription factor binding to both prevent activation of silent enhancers and maintain active regulatory elements

   Andria Koulle, Oluwaseun Ogundele ... Brian Hendrich
2. 1. Chromosomes and Gene Expression

   ATAD2 mediates chromatin-bound histone chaperone turnover

   Ariadni Liakopoulou, Fayçal Boussouar ... Saadi Khochbin

   ATAD2 orchestrates histone turnover during spermatogenesis, regulating H3.3 deposition, chromatin condensation, and genome packaging to ensure proper sperm genome organization and transcriptional control.
3. 1. Chromosomes and Gene Expression
   2. Cancer Biology

   p53-induced RNA-binding protein ZMAT3 inhibits transcription of a hexokinase to suppress mitochondrial respiration

   Ravi Kumar, Simon Couly ... Ashish Lal
4. 1. Chromosomes and Gene Expression
   2. Immunology and Inflammation

   The long non-coding RNA Dreg1 is required for optimal ILC2 development

   Sara Quon, Adelynn Tang ... Rhys S Allan
5. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Chromosomes: Finding a role for non-coding DNA in trypanosomes

   Markus R Schmidt

   Non-coding DNA is essential for both humans and trypanosomes, despite the large evolutionary divergence between these two species.
6. 1. Chromosomes and Gene Expression
   2. Structural Biology and Molecular Biophysics

   Short activation domains control chromatin association of transcription factors

   Vinson B Fan, Abrar A Abidi ... Max V Staller

   Single-molecule tracking of transcription factors in living cells revealed how mutations that make short activation domains stronger increased the fraction of transcription factor molecules bound to chromatin and led to longer residence times on chromatin.
7. 1. Chromosomes and Gene Expression

   Fragile nucleosomes are essential for RNA Polymerase II to transcribe in eukaryotes

   Lingbo Li, Samuel Hunter ... Gongyi Zhang
8. 1. Chromosomes and Gene Expression

   Structural characterisation of chromatin remodelling intermediates supports linker DNA dependent product inhibition as a mechanism for nucleosome spacing

   Amanda L Hughes, Ramasubramanian Sundaramoorthy, Tom Owen-Hughes
9. 1. Chromosomes and Gene Expression

   Identification of the Regulatory Elements and Protein Substrates of Lysine Acetoacetylation

   Qianyun Fu, Terry Nguyen ... Y George Zheng
10. 1. Cancer Biology
    2. Chromosomes and Gene Expression

    Degradation of LMO2 in T cell leukaemia results in collateral breakdown of transcription complex partners and causes LMO2-dependent apoptosis

    Naphannop Sereesongsaeng, Carole Bataille ... Terence Rabbitts

    Antibody surrogate degraders of LMO2 indicate that transcription complexes are susceptible to drug discovery and are therefore druggable.