Chromosomes and Gene Expression

Chromosomes and Gene Expression

eLife reviews research ranging from transcription and RNA processing to epigenetics and chromatin biology. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Evidence of off-target probe binding affecting 10x Genomics Xenium gene panels compromise accuracy of spatial transcriptomic profiling

    Caleb Hallinan, Hyun Joo Ji ... Jean Fan
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Chromosomes and Gene Expression

    TAD boundaries and gene activity are uncoupled

    Faisal Almansour, Nadezda A Fursova ... Tom Misteli
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Chromosomes and Gene Expression

    Interplay between cohesin and TORC1 links chromosome segregation and gene expression to environmental changes

    Dorian Besson, Sabine Vaur ... Jean-Paul Javerzat
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    • Convincing
    1. Chromosomes and Gene Expression
    2. Medicine

    Gene dosage imbalance disrupts systemic metabolism in the Dp16 Down syndrome mouse model

    Fangluo Chen, Muzna Saqib ... G William Wong
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Chromosomes and Gene Expression

    UV irradiation alters TFAM binding specificity and compaction of DNA

    Dillon E King, Emily E Beard ... Joel Meyer
    Independent experimental approaches demonstrate changes in TFAM binding to UVC-irradiated DNA, providing a potential mechanism for DNA damage sensing in the mitochondria.
    1. Chromosomes and Gene Expression

    Single Domain Antibody Inhibitors Target the Coiled Coil Arms of the Bacillus subtilis SMC complex

    Ophélie Gosselin, Michael Taschner ... Stephan Gruber
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    DNA O-MAP uncovers the molecular neighborhoods associated with specific genomic loci

    Yuzhen Liu, Christopher D McGann ... Devin K Schweppe
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Epigenetics and chromatin structure regulate var2csa expression and the placental binding phenotype in Plasmodium falciparum

    Todd Lenz, Madle Sirel ... Ulf Ribacke
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Dynamic RNA Polymerase compartments organize the transcription of gene clusters

    Yi-Hui Wang, Hannah L Hertz, Wen Tang
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Dietary sulfur amino acid restriction elicits a cold-like transcriptional response in inguinal but not epididymal white adipose tissue of male mice

    Philip MM Ruppert, Aylin S Gueller ... Jan-Wilhelm Kornfeld
    Transcriptomic profiling on liver and adipose depots reveals tissue-specific and beige-fat–convergent responses to methionine restriction and cold, providing a high-quality resource to guide combinatorial lifestyle interventions for metabolic disease research.
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Highlights

    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Chromosomes: Finding a role for non-coding DNA in trypanosomes

    Markus R Schmidt
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Chromosomes: Exploring a crossroads in the aging process

    Kiyan Shabestary, Daniel E Gottschling
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Homologous Recombination: Snapshot of an intermediate structure

    Akira Shinohara

Senior editors

  1. Yamini Dalal
    National Cancer Institute, United States
  2. Adèle L Marston
    University of Edinburgh, United Kingdom
  3. Lori Sussel
    University of Colorado Anschutz Medical Campus, United States
  4. See more editors