Chromosomes and Gene Expression

Latest articles

1. 1. Chromosomes and Gene Expression
   2. Evolutionary Biology

   The emergence and evolution of gene expression in genome regions replete with regulatory motifs

   Timothy Fuqua, Yiqiao Sun, Andreas Wagner

   Mutagenizing sequences enriched with promoter motifs creates gene expression de novo, and helps to understand promoter logic, regulatory evolution, and the birth of de novo genes.
2. 1. Chromosomes and Gene Expression
   2. Developmental Biology

   N-terminus of Drosophila melanogaster MSL1 is critical for dosage compensation

   Valentin Babosha, Natalia Klimenko ... Oksana Maksimenko

   N‑terminus of MSL1 protein, involved in dosage compensation in Drosophila, is required for the interaction with non-coding roX2 RNA and the assembly of the complex on the male X chromosome.
3. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   A genome-wide nucleosome-resolution map of promoter-centered interactions in human cells corroborates the enhancer-promoter looping model

   Arkadiy K Golov, Alexey A Gavrilov ... Sergey V Razin

   A new genomic method called MChIP-C measures H3K4me3-associated chromatin interactions with extremely high resolution and sensitivity, detecting interactions in over 60% of functionally verified enhancer-promoter pairs.
4. 1. Developmental Biology
   2. Chromosomes and Gene Expression

   Drosophila Hamlet mediates epithelial tissue assembly of the reproductive system

   Huazhen Wang, Ludivine Bertonnier-Brouty ... Qi Dai
5. 1. Chromosomes and Gene Expression

   Prolonged cell cycle arrest in response to DNA damage in yeast requires the maintenance of DNA damage signaling and the spindle assembly checkpoint

   Felix Y Zhou, David P Waterman ... James E Haber

   Cell cycle arrest in response to a double-stranded break is initially maintained by the DNA damage checkpoint and later by the spindle assembly checkpoint.
6. 1. Chromosomes and Gene Expression

   Decapping activators Edc3 and Scd6 act redundantly with Dhh1 in post-transcriptional repression of starvation-induced pathways

   Rakesh Kumar, Fan Zhang ... Alan G Hinnebusch
7. 1. Chromosomes and Gene Expression
   2. Developmental Biology

   Complex aneuploidy triggers autophagy and p53-mediated apoptosis and impairs the second lineage segregation in human preimplantation embryos

   Marius Regin, Yingnan Lei ... Claudia Spits

   Aneuploid human embryonic cells are eliminated by p53-mediated apoptosis in a gene dosage dependent manner.
8. 1. Chromosomes and Gene Expression
   2. Developmental Biology

   Unified bursting strategies in ectopic and endogenous even-skipped expression patterns

   Augusto Berrocal, Nicholas C Lammers ... Michael B Eisen

   Drosophila melanogastereven-skipped enhancers control transcriptional bursting by modulating frequency and amplitude, regardless of varying transcription factor inputs, even when mutated to express in embryonic regions not under selective pressure.
9. 1. Structural Biology and Molecular Biophysics
   2. Chromosomes and Gene Expression

   Surprising Features of Nuclear Receptor Interaction Networks Revealed by Live Cell Single Molecule Imaging

   Liza Dahal, Thomas GW Graham ... Xavier Darzacq
10. 1. Chromosomes and Gene Expression

    The Smc5/6 complex counteracts R-loop formation at highly transcribed genes in cooperation with RNase H2

    Shamayita Roy, Hemanta Adhikary ... Damien D'Amours

    Genetic analyses in budding yeast coupled with biochemical assays have revealed an unexpected role for the Smc5/6 complex in cellular pathways responsible for the prevention of RNA formation in genomic DNA.