Chromosomes and Gene Expression

Latest articles

1. 1. Chromosomes and Gene Expression
   2. Plant Biology

   Short heat shock factor A2 confers heat sensitivity in Arabidopsis: Insights into heat resistance and growth balance

   Wanxia Chen, Jiaqi Zhao ... Xiaoting Qi
2. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   DNA methylation insulates genic regions from CTCF loops near nuclear speckles

   Shelby A Roseman, Allison P Siegenfeld ... Brian B Liau

   CTCF binding promotes chromatin-nuclear speckle interactions and gene activation after DNA demethylation, yet its binding and looping patterns are unaffected by speckle depletion.
3. 1. Chromosomes and Gene Expression

   Nuclear and cytosolic J-domain proteins provide synergistic control of Hsf1 at distinct phases of the heat shock response

   Carmen Ruger-Herreros, Lucia Svoboda ... Bernd Bukau
4. 1. Chromosomes and Gene Expression
   2. Immunology and Inflammation

   Cap-independent co-expression of dsRNA-sensing and NF-κB pathway inhibitors enables controllable self-amplifying RNA expression with reduced immunotoxicity

   Tony KY Lim, Anne Ritoux ... Ewan St John Smith

   Engineering self-amplifying RNA to intrinsically disarm the innate immune pathways it triggers enables durable, externally controlled gene expression with reduced cytotoxicity and cytokine release, eliminating the need for exogenous immunosuppressants.
5. 1. Cell Biology
   2. Chromosomes and Gene Expression

   Enalapril mitigates senescence and aging-related phenotypes in human cells and mice via pSmad1/5/9-driven antioxidative genes

   Wencong Lyu, Haochen Wang ... Wei Tao

   Enalapril combats the effects of senescence by activating the pSmad1/5/9–antioxidative gene axis, enhancing antioxidative defenses and promoting cell proliferation, thereby supporting healthy aging.
6. 1. Chromosomes and Gene Expression
   2. Microbiology and Infectious Disease

   Human cytomegalovirus infection coopts chromatin organization to diminish TEAD1 transcription factor activity

   Khund Sayeed, Sreeja Parameswaran ... Matthew T Weirauch
7. 1. Chromosomes and Gene Expression
   2. Computational and Systems Biology

   Evidence of off-target probe binding in the 10x Genomics Xenium v1 Human Breast Gene Expression Panel compromises accuracy of spatial transcriptomic profiling

   Caleb Hallinan, Hyun Joo Ji ... Jean Fan
8. 1. Chromosomes and Gene Expression
   2. Structural Biology and Molecular Biophysics

   Homologous Recombination: Snapshot of an intermediate structure

   Akira Shinohara

   Cryogenic electron microscopy has been used to determine the detailed structure of an intermediate state called a “D-loop” that forms when strands of DNA are exchanged during homologous recombination.
9. 1. Chromosomes and Gene Expression
   2. Structural Biology and Molecular Biophysics

   Structural mechanism of strand exchange by the RAD51 filament

   Luay Joudeh, Robert E Appleby ... Luca Pellegrini

   The cryoEM structure of a RAD51 displacement loop reveals the molecular mechanism of the strand-exchange reaction at the centre of eukaryotic homologous recombination.
10. 1. Cancer Biology
    2. Chromosomes and Gene Expression

    Interplay of YEATS2 and GCDH regulates histone crotonylation and drives EMT in head and neck cancer

    Deepak Pant, Parik Kakani ... Sanjeev Shukla

    YEATS2 and GCDH are upregulated in head and neck cancer in an SP1-dependent manner, leading to enhanced levels of promoter histone crotonylation which in turn elevates expression of EMT-associated SPARC.