Chromosomes and Gene Expression

Latest articles

1. 1. Cancer Biology
   2. Chromosomes and Gene Expression

   Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition

   Gregory Caleb Howard, Jing Wang ... William P Tansey

   Analysis of the action of WDR5 inhibitors in leukemia cells reveals decreased ribosome inventory, impaired protein synthesis, induction of nucleolar stress, and activation of p53 via alternative splicing of MDM4.
2. 1. Chromosomes and Gene Expression
   2. Evolutionary Biology

   The domesticated transposon protein L1TD1 associates with its ancestor L1 ORF1p to promote LINE-1 retrotransposition

   Gülnihal Kavaklıoğlu, Alexandra Podhornik ... Christian Seiser
3. 1. Chromosomes and Gene Expression
   2. Immunology and Inflammation

   Foxp3 depends on Ikaros for control of regulatory T cell gene expression and function

   Rajan M Thomas, Matthew C Pahl ... Andrew D Wells

   Foxp3 and Ikaros, two transcription factors genetically linked to autoimmune disease in humans, cooperate to establish the epigenomic and transcriptomic landscape of regulatory T cells.
4. 1. Cell Biology
   2. Chromosomes and Gene Expression

   Heat stress impairs centromere structure and segregation of meiotic chromosomes in Arabidopsis

   Lucie Crhak Khaitova, Pavlina Mikulkova ... Karel Riha

   The sensitivity of Arabidopsis meiotic centromeres to heat stress suggests that centromere function is one of the key determinants of plant reproduction under rising temperatures.
5. 1. Developmental Biology
   2. Chromosomes and Gene Expression

   N-Terminus of Drosophila Melanogaster MSL1 Is Critical for Dosage Compensation

   Valentin Babosha, Natalia Klimenko ... Oksana Maksimenko
6. 1. Chromosomes and Gene Expression
   2. Cancer Biology

   Pharmacologic inhibition of BAF chromatin remodeling complexes as a therapeutic approach to transcription factor-dependent cancers

   Richard C. Centore, Luis M. M. Soares ... Steven F. Bellon
7. 1. Chromosomes and Gene Expression

   Post-transcriptional splicing can occur in a slow-moving zone around the gene

   Allison Coté, Aoife O'Farrell ... Arjun Raj

   The existence of a slow-moving zone around the transcription site may unify conflicting models of co-transcriptional versus post-transcriptional mRNA splicing.
8. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Single-cell ‘omic profiles of human aortic endothelial cells in vitro and human atherosclerotic lesions ex vivo reveal heterogeneity of endothelial subtype and response to activating perturbations

   Maria L Adelus, Jiacheng Ding ... Casey E Romanoski

   Primary endothelial cell cultures contain markedly heterogeneous cell subtypes that exhibit distinct molecular responses to disease-relevant exposures.
9. 1. Chromosomes and Gene Expression

   Transcriptome-wide analysis of the function of Ded1 in translation preinitiation complex assembly in a reconstituted in vitro system

   Fujun Zhou, Julie M Bocetti ... Jon R Lorsch

   A new in vitro approach allows measurement of the efficiency of the early steps of translation initiation on every messenger RNA in yeast simultaneously.
10. 1. Chromosomes and Gene Expression

    Artificially inserted G-quadruplex DNA secondary structures induce long-distance chromatin activation

    Shuvra Shekhar Roy, Sulochana Bagri ... Shantanu Chowdhury