Genetics and Genomics

Genetics and Genomics

eLife reviews research including the genetic basis of health and disease, epigenetics, genomics, medical genetics, genetic epidemiology, and population genetics. Learn more about what we review and sign up for the latest research.
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Latest articles

    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Heterogeneous associations of polygenic indices of 35 traits with mortality: a register-linked population-based follow-up study

    Hannu Lahtinen, Jaakko Kaprio ... Pekka Martikainen
    Polygenic indices related to the best-established social, psychological, and behavioural mortality risk phenotypes had the strongest associations with mortality.
    1. Developmental Biology
    2. Genetics and Genomics

    Equity, Diversity and Inclusion: Four women whose pioneering contributions to science have been largely overlooked

    Lisa M Thomann, Julie Batut
    Ethel Browne Harvey, Hilde Pröscholdt Mangold, Ida Henrietta Hyde and Marthe Gautier all made important contributions to developmental biology, but their names are largely absent from histories of science.
    1. Genetics and Genomics
    2. Computational and Systems Biology

    Human-specific lncRNAs contributed critically to human evolution by distinctly regulating gene expression

    Jie Lin, Yujian Wen ... Hao Zhu
    Revised
    Reviewed Preprint v5
    Updated
    • Valuable
    • Solid
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Distinct chromatin regulators downmodulate meiotic axis protein deposition and DNA break induction at chromosome ends

    Adhithi R Raghavan, Kieron May ... Andreas Hochwagen
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    EPB41L4A-AS1 long noncoding RNA acts in both cis- and trans-acting transcriptional regulation and controls nucleolar biology

    Alan Monziani, Juan Pablo Unfried ... Igor Ulitsky
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Developmental Biology
    2. Genetics and Genomics

    Single-cell transcriptomics of X-ray irradiated Drosophila wing discs reveals heterogeneity related to cell-cycle status and cell location

    Joyner Cruz, William Y Sun ... Iswar K Hariharan
    Even in a simple epithelial tissue that is exposed uniformly to X-ray irradiation, cells show marked differences in their transcriptional response based on their location and cell-cycle status.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Polymorphisms in intron 1 of HLA-DRA differentially associate with type 1 diabetes and celiac disease and implicate involvement of complement system genes C4A and C4B

    Ozkan Aydemir, Jeffrey A Bailey ... TEDDY Study Group
    HLA-DRA intronic haplotype associates with opposite effects on type 1 diabetes and celiac disease, refining genetic risk prediction and implicating complement genes C4A and C4B in divergent autoimmune pathways.
    1. Genetics and Genomics

    RiboTRAP-seq identifies spatially distinct functions for the anterior and posterior intestine in immune and metabolic regulation in C. elegans

    Chung-Chih Liu, Nicolas Seban, Supriya Srinivasan
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Genetics and Genomics

    Maternal SETDB1 enables development beyond cleavage stages by extinguishing the MERVL-driven 2-cell totipotency transcriptional program in the mouse embryo

    Tie-Bo Zeng, Zhen Fu ... Piroska E Szabó
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Genetics and Genomics
    2. Plant Biology

    AT-HOOK-MOTIF NUCLEAR LOCALIZED 15 extends plant longevity by binding at poorly accessible, epigenetic mark-depleted chromatin that surrounds transcribed regions

    Thalia Luden, Jihed Chouaref, Remko Offringa
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    • Solid
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Highlights

    1. Developmental Biology
    2. Genetics and Genomics

    Women who have been overlooked

    Lisa M Thomann, Julie Batut
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology
    3. Genetics and Genomics

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    1. Genetics and Genomics
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Senior editors

  1. Kathryn Cheah
    The University of Hong Kong, Hong Kong SAR China
  2. Yamini Dalal
    National Cancer Institute, United States
  3. Adèle L Marston
    University of Edinburgh, United Kingdom
  4. See more editors