Genetics and Genomics

Genetics and Genomics

eLife reviews research including the genetic basis of health and disease, epigenetics, genomics, medical genetics, genetic epidemiology, and population genetics. Learn more about what we review and sign up for the latest research.
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Latest articles

    1. Genetics and Genomics
    2. Cancer Biology

    Multimodal single-cell analyses reveal distinct fusion-regulated transcriptional programs in Ewing sarcoma

    Olivia G Waltner, April A Apfelbaum ... Scott N Furlan
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Genetics and Genomics

    Stranded short nascent strand sequencing reveals the topology of DNA replication origins in Trypanosoma brucei

    Slavica Stanojcic, Bridlin Barckmann ... Yvon Sterkers
    Not revised
    Reviewed Preprint v1
    • Inadequate
    1. Genetics and Genomics
    2. Computational and Systems Biology

    Evolutionary remodeling of non-canonical ORF translation in mammals

    Yue Chang, Tianyu Lei ... Hong Zhang
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Evolutionary Biology
    2. Genetics and Genomics

    The primate Major Histocompatibility Complex as a case study of gene family evolution

    Alyssa Lyn Fortier, Jonathan K Pritchard
    The Major Histocompatibility Complex region evolves via gene birth-and-death, resulting in short-lived genes, rapidly expanding gene subfamilies, and many gene fragments.
    1. Genetics and Genomics
    2. Evolutionary Biology

    Pre-Cambrian origin of envelope-carrying retrotransposons in metazoans

    Shashank Chary, Rippei Hayashi
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Genetics and Genomics
    2. Stem Cells and Regenerative Medicine

    Joint profiling of cell morphology and gene expression during in vitro neurodevelopment

    Adithi Sundaresh, Dimitri Meistermann ... Helena Kilpinen
    Molecular and morphological profiles of developing neurons in vitro uncover the cellular dynamics of human neurodevelopment and related disease.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Neisseria gonorrhoeae LIN codes: a Robust, Multi-Resolution Lineage Nomenclature

    Anastasia Unitt, Made Krisna ... Odile B Harrison
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Genetics and Genomics

    Functional analysis across model systems implicates ribosomal proteins in growth and proliferation defects associated with hypoplastic left heart syndrome

    Tanja Nielsen, Anaïs Kervadec ... Alexandre R Colas
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    High-throughput development and characterization of new functional nanobodies for gene regulation and epigenetic control in human cells

    Jun Wan, Abby R Thurm ... Lacramioara Bintu
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Genetics and Genomics
    2. Neuroscience

    Avoidance of hydrogen sulfide is modulated by external and internal states in Caenorhabditis elegans

    Longjun Pu, Lina Zhao ... Changchun Chen
    Mitochondrial remodeling, ROS-dependent signaling, and diverse environmental and physiological cues underlie the initiation and persistence of locomotory activity of C. elegans in toxic H2S.
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Highlights

    1. Genetics and Genomics

    Epigenetic inheritance in C. elegans

    Lesley T MacNeil
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology
    3. Genetics and Genomics

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    1. Genetics and Genomics
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Senior editors

  1. Murim Choi
    Seoul National University College of Medicine, South Korea
  2. Yamini Dalal
    National Cancer Institute, United States
  3. Adèle L Marston
    University of Edinburgh, United Kingdom
  4. See more editors