Genetics and Genomics

Latest articles

1. 1. Genetics and Genomics
   2. Physics of Living Systems

   Raman Spectroscopy: Probing the proteome

   Wei-Hsiang Lin, Chia-Liang Cheng

   Raman spectroscopy can be used to predict cellular physiology and proteome composition in E. coli.
2. 1. Cancer Biology
   2. Genetics and Genomics

   Replication stress-inducing ELF3 upregulation promotes BRCA1-deficient breast tumorigenesis in luminal progenitors

   Jiadong Zhou, Xiao Albert Zhou ... Jiadong Wang

   A replication stress–ELF3 axis enables luminal progenitor transformation in BRCA1-deficient breast cancer by reducing genomic instability and promoting progenitor identity.
3. 1. Genetics and Genomics

   A default silencing mechanism restrains stress-induced genes in C. elegans

   Orkan Ilbay, Alejandro Rodriguez Gama ... Andrew Fire
4. 1. Genetics and Genomics
   2. Neuroscience

   Integrating bulk and single cell RNA-seq refines transcriptomic profiles of individual C. elegans neurons

   Alec Barrett, Erdem Varol ... Marc Hammarlund
5. 1. Genetics and Genomics
   2. Neuroscience

   Opioid Use Disorder: Identifying new targets in the fight against opioids

   Fernanda Laezza

   Experiments reveal that a time-dependent epistatic interaction influences how mice respond to opioids, and that intracellular fibroblast growth factors also influence opioid sensitivity.
6. 1. Genetics and Genomics
   2. Microbiology and Infectious Disease

   Deletion of the moeA gene in Flavobacterium IR1 drives structural color shift from green to blue and alters polysaccharide metabolism

   Álvaro Escobar Doncel, Constantinos Patinios ... Colin J Ingham

   Disrupting a single molybdenum cofactor gene allowed us to connect metabolic regulation of complex carbohydrates with cell organization, enabling genetic tuning of bacterial structural color for biomaterial applications.
7. 1. Genetics and Genomics
   2. Microbiology and Infectious Disease

   Neisseria gonorrhoeae LIN codes provide a robust, multi-resolution lineage nomenclature

   Anastasia Unitt, Made A Krisna ... Odile B Harrison

   LIN code offers a reliable framework for classifying gonococcal population structure, enabling straightforward exploration of isolate relationships, from broad superlineage divisions to minute single allele differences.
8. 1. Evolutionary Biology
   2. Genetics and Genomics

   Hybridization breaks species barriers in long-term coevolution of a cyanobacterial population

   Gabriel Birzu, Harihara Subrahmaniam Muralidharan ... Devaki Bhaya

   Analysis of hundreds of single-cell genomes from Yellowstone National Park shows bacterial species are less cohesive than previously thought.
9. 1. Genetics and Genomics
   2. Medicine

   Translational reading frame determines the pathogenicity of C-terminal frameshift deletions in MeCP2: an alternative therapeutic approach

   Jacky Guy, Elena Hein ... Adrian Bird
10. 1. Developmental Biology
    2. Genetics and Genomics

    Computer prediction and genetic analysis identifies retinoic acid modulation as a driver of conserved longevity pathways in genetically diverse Caenorhabditis nematodes

    Stephen A Banse, Christine A Sedore ... Patrick C Phillips

    Computer screening identifies that the widely prescribed vitamin A derivative all-trans retinoic acid increases both longevity and late-life health in a powerful genetic model system.