Genetics and Genomics

Latest articles

1. 1. Genetics and Genomics
   2. Neuroscience

   Impaired excitability of fast-spiking neurons in a novel mouse model of KCNC1 epileptic encephalopathy

   Eric R Wengert, Sophie R Liebergall ... Ethan M Goldberg

   Brain slice electrophysiology, immunohistochemistry, and in vivo two-photon calcium imaging identify circuit dysfunction and epilepsy mechanism in a Kcnc1-A421V/+ mouse model of developmental and epileptic encephalopathy.
2. 1. Biochemistry and Chemical Biology
   2. Genetics and Genomics

   Determining the off-target activity of antibiotics and novel translation initiation sites in mitochondria

   James Marks, Emma Young, Markus Hafner
3. 1. Genetics and Genomics

   SETDB1 enables development beyond cleavage stages by extinguishing the MERVL-driven two-cell totipotency transcriptional program in the mouse embryo

   Tie-Bo Zeng, Zhen Fu ... Piroska E Szabó

   Conditional genetics and single-embryo RNA-seq show that SETDB1 extinguishes the transient, retroelement-driven transcriptional programs of the totipotent two-cell state to facilitate the exit from totipotency and ensure preimplantation development.
4. 1. Genetics and Genomics

   Visible traits demonstrate that crispant founder mice can be used for phenotypic assessment

   Rebekah Tillotson, Marina Gertsenstein ... Monica J Justice
5. 1. Genetics and Genomics

   Ribosomal RNA synthesis by RNA polymerase I is subject to premature termination of transcription

   Chaïma Azouzi, Katrin Schwank ... Christophe Dez

   Premature termination of transcription influences ribosomal RNA output and RNA polymerase I drug sensitivity, revealing a mechanism of resistance to transcription-targeting chemotherapy.
6. 1. Epidemiology and Global Health
   2. Genetics and Genomics

   Heterogeneous associations of polygenic indices of 35 traits with mortality: a register-linked population-based follow-up study

   Hannu Lahtinen, Jaakko Kaprio ... Pekka Martikainen

   Polygenic indices related to the best-established social, psychological, and behavioural mortality risk phenotypes had the strongest associations with mortality.
7. 1. Developmental Biology
   2. Genetics and Genomics

   Equity, Diversity and Inclusion: Four women whose pioneering contributions to science have been largely overlooked

   Lisa M Thomann, Julie Batut

   Ethel Browne Harvey, Hilde Pröscholdt Mangold, Ida Henrietta Hyde and Marthe Gautier all made important contributions to developmental biology, but their names are largely absent from histories of science.
8. 1. Developmental Biology
   2. Genetics and Genomics

   PRMT1-SFPQ regulates intron retention to control matrix gene expression during craniofacial development

   Julia Raulino Lima, Nicha Ungvijanpunya ... Jian Xu
9. 1. Genetics and Genomics
   2. Computational and Systems Biology

   Human-specific lncRNAs contributed critically to human evolution by distinctly regulating gene expression

   Jie Lin, Yujian Wen ... Hao Zhu
10. 1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    EPB41L4A-AS1 long noncoding RNA acts in both cis- and trans-acting transcriptional regulation and controls nucleolar biology

    Alan Monziani, Juan Pablo Unfried ... Igor Ulitsky