Genetics and Genomics

Genetics and Genomics

eLife reviews research including the genetic basis of health and disease, epigenetics, genomics, medical genetics, genetic epidemiology, and population genetics. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Developmental Biology
    2. Genetics and Genomics

    Single-cell transcriptomics of X-ray irradiated Drosophila wing discs reveals heterogeneity related to cell-cycle status and cell location

    Joyner Cruz, Willam Y Sun ... Iswar K Hariharan
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Genetics and Genomics

    Non-visual light modulates behavioral memory and gene expression in C. elegans

    Zhijian Ji, Bingying Wang ... Dengke K Ma
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Genetics and Genomics
    2. Epidemiology and Global Health

    Heterogenous associations of polygenic indices of 35 traits with mortality

    Hannu Lahtinen, Jaakko Kaprio ... Pekka Martikainen
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    A novel high-throughput single-cell DNA sequencing method reveals hidden genomic heterogeneity in the unicellular eukaryote Leishmania

    Gabriel H Negreira, Pieter Monsieurs ... Malgorzata A Domagalska
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Genetics and Genomics

    The RNA-binding protein HuR modulates the expression of the disease-linked CCL2 rs1024611G-rs13900T haplotype

    Feroz Akhtar, Joselin Hernandez Ruiz ... Srinivas Mummidi
    Bioinformatics, RNA-protein interactions, and HuR-based functional studies demonstrated that the rs13900T allele modulates CCL2 transcript levels, providing a functional link between the CCL2 rs1024611G-rs13900T haplotype and disease susceptibility/progression.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Chromosomes: Finding a role for non-coding DNA in trypanosomes

    Markus R Schmidt
    Non-coding DNA is essential for both humans and trypanosomes, despite the large evolutionary divergence between these two species.
    Version of Record
    Insight
    1. Genetics and Genomics

    Khdc3 Regulates Metabolism Across Generations in a DNA-Independent Manner

    Liana Senaldi, Nora Hassan ... Matthew Smith-Raska
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Genetics and Genomics

    The Impact of Stability Considerations on Genetic Fine-mapping

    Alan J Aw, Lionel Chentian Jin ... Yun S Song
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Developmental Biology
    2. Genetics and Genomics

    In situ mutational screening and CRISPR interference reveal that the apterous Early enhancer is required for developmental boundary positioning

    Gustavo Aguilar, Michèle Sickmann ... Martin Müller
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Cell Biology
    2. Genetics and Genomics

    Cross-species evaluation of TANGO2 homologs, including HRG-9 and HRG-10 in Caenorhabditis elegans, challenges a proposed role in heme trafficking

    Sarah E Sandkuhler, Kayla S Youngs ... Samuel J Mackenzie
    Evidence from multiple model systems supports a shift away from heme transport and toward metabolic dysfunction and oxidative stress as key drivers of TANGO2 deficiency.
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Highlights

    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Non-coding DNA in trypanosomes

    Markus R Schmidt
    1. Genetics and Genomics
    2. Physics of Living Systems

    Probing the proteome

    Wei-Hsiang Lin, Chia-Liang Cheng
    1. Genetics and Genomics
    2. Neuroscience

    Targeting opioid addiction

    Fernanda Laezza

Senior editors

  1. Kathryn Cheah
    The University of Hong Kong, Hong Kong SAR China
  2. Murim Choi
    Seoul National University College of Medicine, South Korea
  3. Yamini Dalal
    National Cancer Institute, United States
  4. See more editors