Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
PITAR interaction with TRIM28 mRNA, which encodes a p53 targeting E3 ubiquitin ligase, keeps p53 levels low for cancer cells to divide and attenuates the DNA damage response by p53.
Nerve tracing and behavioral studies in tumor-bearing mice together with transcriptional and functional analysis reveal cancer-induced central and peripheral neuronal alterations that influence behavior.
Analysis of neonatal response reveals that at 37 weeks gestational age, infants exhibit a marked developmental shift in their ability to perceive emotional vocal prosody, highlighting a critical period for social emotional development with potential implications for early neurodevelopmental assessments.
Lipoprotein particle size and composition, fatty acids, and amino acids were associated with the risk of incident diabetes, and adding the selected metabolites could significantly improve the risk prediction of progression from prediabetes to diabetes beyond the conventional clinical variables.
Luis Alberto Bezares Calderón, Réza Shahidi, Gáspár Jékely
Ciliated zooplankton larvae sense pressure by ciliary photoreceptor cells, which increase the beating of locomotor cilia via a serotonergic motor circuit leading to rapid upward swimming during barotaxis.
Frederick Federer, Justin Balsor ... Alessandra Angelucci
The gene-regulatory enhancers h56D and S5E2 restrict transgene expression to GABAergic and parvalbumin-positive interneurons, respectively, across marmoset cortical layers, thus representing a promising tool for circuit dissection in non-human primates.
The male-specific tumor-suppressive effects of minor p53 isoforms were correlated with higher Ackr4 expression levels, which have implications for sex-specific cancer prognosis in humans.
