When two signals increase transcription of the same gene, their combined effect tends to reflect either the sum of the individual increases or the product of the individual fold-changes.
Anika Stockert, Michael Schwartze ... Sonja A Kotz
With unique lesion-informed tractography, left hemisphere temporo-cerebellar structural connectivity has been established, supporting rapid auditory transmission and cortical functional lateralization.
Giordano de Guglielmo, Lieselot Carrette ... Olivier George
Genetically diverse rats reveal a single underlying construct linking key addiction-like behaviors, challenging compulsivity as an independent measure, and offering a new perspective on vulnerability and resilience to addiction.
Combination of glutaminase inhibitor CB-839 and ASCT2 inhibitor V-9302 showed efficient antitumor effect against glutamine addicted liver cancer cells via glutathione depletion and reactive oxygen species (ROS) induction.
Claire E Stelly, Matthew B Pomrenze ... Hitoshi Morikawa
Enhanced glutamatergic synaptic plasticity in mesolimbic dopaminergic neurons may contribute to repeatedly stressed rats becoming more vulnerable to addiction.
Alexandra M Stafford, Cheryl Reed ... Tamara J Phillips
The trace amine-associated receptor 1 gene has a causal role in methamphetamine intake and thermal response, and interacts with the mu-opioid receptor gene in its methamphetamine addiction-related effects.
Christian Louis Bonatto Paese, Anna Schoenauer ... Alistair P McGregor
Sox21b-1 regulates simultaneous formation of anterior segments and addition of posterior segments in a spider, which resembles segmentation in long- and short-germ insects, and suggests SoxB regulation of segmentation is an ancestral feature of arthropods.
A newly identified pattern of circuit assembly shows connectivity between small groups of neurons born in tight time windows from different stem cells, with outputs from one lineage born before inputs from other lineages.
