445 results found
    1. Ecology
    2. Evolutionary Biology

    Sensory conflict disrupts circadian rhythms in the sea anemone Nematostella vectensis

    Cory A Berger, Ann M Tarrant
    Misalignment between light and temperature cycles leads to disrupted circadian behavior and a substantially altered rhythmic transcriptome.
    1. Cell Biology

    Evidence for a role of human blood-borne factors in mediating age-associated changes in molecular circadian rhythms

    Jessica E Schwarz, Antonijo Mrčela ... Amita Sehgal
    Blood-borne factors contribute to changes in the circadian transcriptome with age.
    Version of Record
    Short Report
    • Fundamental
    • Compelling
    1. Computational and Systems Biology
    2. Neuroscience

    A common alteration in effort-based decision-making in apathy, anhedonia, and late circadian rhythm

    Sara Z Mehrhof, Camilla L Nord
    Individuals with a late circadian rhythm show the same deficits in motivational decision-making as those with neuropsychiatric symptoms, but only when tested in the morning.
    1. Medicine

    Gut microbe-targeted choline trimethylamine lyase inhibition improves obesity via rewiring of host circadian rhythms

    Rebecca C Schugar, Christy M Gliniak ... Jonathan Mark Brown
    Small molecule inhibitors of gut microbial choline trimethylamine lyase activity protect against obesity.
    1. Computational and Systems Biology
    2. Plant Biology

    Coordination of robust single cell rhythms in the Arabidopsis circadian clock via spatial waves of gene expression

    Peter D Gould, Mirela Domijan ... James CW Locke
    Single cell analysis reveals how period differences between cells and cell-to-cell coupling generates the spatial structure of the plant circadian clock.
    1. Computational and Systems Biology
    2. Neuroscience

    The sleep-wake distribution contributes to the peripheral rhythms in PERIOD-2

    Marieke MB Hoekstra, Maxime Jan ... Paul Franken
    Sleep-wake patterns, together with a suprachiasmatic nuclei-independent circadian factor, are necessary and sufficient to maintain high-amplitude nychthemeral rhythms in PERIOD-2.
    1. Neuroscience

    Loss of ZBTB20 impairs circadian output and leads to unimodal behavioral rhythms

    Zhipeng Qu, Hai Zhang ... Ying Xu
    The zinc finger protein ZBTB20 is a morning and evening activity gating factor in mice.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Circadian RNA expression elicited by 3’-UTR IRAlu-paraspeckle associated elements

    Manon Torres, Denis Becquet ... Anne-Marie François-Bellan
    Circadian gene expression can be driven by a post-transcriptional mechanism involving circadian mRNA nuclear retention by paraspeckle nuclear bodies.
    1. Cell Biology
    2. Genetics and Genomics

    The nutrient-sensing GCN2 signaling pathway is essential for circadian clock function by regulating histone acetylation under amino acid starvation

    Xiao-Lan Liu, Yulin Yang ... Xiao Liu
    The nutrient-sensing GCN2 signaling pathway is required for robust circadian rhythm by recruiting the histone acetyltransferase GCN5 to establish a proper chromatin state at the circadian clock gene promoter under amino acid starvation in Neurospora.
    1. Genetics and Genomics
    2. Neuroscience

    Dissection of central clock function in Drosophila through cell-specific CRISPR-mediated clock gene disruption

    Rebecca Delventhal, Reed M O'Connor ... Mimi Shirasu-Hiza
    Through novel, cell-specific CRISPR tools to disrupt molecular clock genes, it was revealed that circadian rhythms are coordinated through a network, rather than by the clock of 'master regulatory' neurons.

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