845 results found
    1. Structural Biology and Molecular Biophysics

    Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals

    Ho Yee Joyce Fung, Szu-Chin Fu, Yuh Min Chook
    Building on previous work (Fung et al., 2015), the structures of eight new nuclear export signal (NES) peptides bound to Exportin CRM1 are reported, revealing striking diversity in NES structures, a small conserved secondary structural element, and a CRM1 residue that functions as a selectivity filter.
    1. Structural Biology and Molecular Biophysics

    A modular platform for automated cryo-FIB workflows

    Sven Klumpe, Herman KH Fung ... Julia Mahamid
    SerialFIB is an adaptable open-source software designed for streamlining, advanced development and automation of cryo-focused ion beam-based cellular preparations for in situ cryo-electron tomography.
    1. Developmental Biology
    2. Evolutionary Biology

    Gene age shapes the transcriptional landscape of sexual morphogenesis in mushroom-forming fungi (Agaricomycetes)

    Zsolt Merényi, Máté Virágh ... László G Nagy
    Allele-specific expression, natural antisense transcripts, and developmental gene expression, but not RNA editing or developmental hourglass, act in concert to shape the transcriptome during the fruiting body formation of complex multicellular fungi.
    1. Cell Biology

    Lipid hydroperoxides promote sarcopenia through carbonyl stress

    Hiroaki Eshima, Justin L Shahtout ... Katsuhiko Funai
    Genetic or pharmacological suppression of lipid peroxidation pathway protects skeletal muscle from disuse-induced atrophy and weakness in young and old mice.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural determinants of nuclear export signal orientation in binding to exportin CRM1

    Ho Yee Joyce Fung, Szu-Chin Fu ... Yuh Min Chook
    Some nuclear export signals (NESs) bind to the transport receptor CRM1 in the opposite orientation to those previously studied.
    1. Genetics and Genomics

    Codon optimization underpins generalist parasitism in fungi

    Thomas Badet, Remi Peyraud ... Sylvain Raffaele
    Codon optimization through biased synonymous substitutions is a characteristic feature of the genomes of generalist fungal parasites and is associated with the colonization of multiple hosts.
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    1. Genetics and Genomics

    Comprehensive re-analysis of hairpin small RNAs in fungi reveals loci with conserved links

    Nathan R Johnson, Luis F Larrondo ... Elena A Vidal
    A critical assessment of published microRNA/microRNA-like provides clues on features and conservation of these hairpin RNAs in fungi in addition to a centralized loci annotation resource for the community.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Comment on 'Single nucleus sequencing reveals evidence of inter-nucleus recombination in arbuscular mycorrhizal fungi'

    Benjamin Auxier, Anna Bazzicalupo
    We are writing to comment on the article by Chen et al. (2018) about inter-nucleus recombination in arbuscular mycorrhizal fungi.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Punctuated evolution and transitional hybrid network in an ancestral cell cycle of fungi

    Edgar M Medina, Jonathan J Turner ... Nicolas E Buchler
    Cell cycle network evolution in a fungal ancestor was punctuated by the arrival of a viral DNA-binding protein that was permanently incorporated into the regulatory network controlling cell cycle entry.
    1. Ecology
    2. Plant Biology

    Blumenols as shoot markers of root symbiosis with arbuscular mycorrhizal fungi

    Ming Wang, Martin Schäfer ... Ian T Baldwin
    Arbuscular mycorrhizal fungi-induced hydroxy- and carboxyblumenol C glycosides accumulate in plant shoots and allow for facile high-throughput screening for functional plant-AMF associations.

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