136 results found
    1. Physics of Living Systems

    Mitigating memory effects during undulatory locomotion on hysteretic materials

    Perrin E Schiebel, Henry C Astley ... Daniel I Goldman
    Undulatory animals moving on the surface must manage material memory by either having a slender anatomy that facilitates avoiding previously remodeled substrate, or using waveshapes that effectively utilize the memory.
    1. Neuroscience

    Response repetition biases in human perceptual decisions are explained by activity decay in competitive attractor models

    James J Bonaiuto, Archy de Berker, Sven Bestmann
    Residual activity from previous trials in a biophysical decision network model causes biases in choice behavior such that a previous response is more likely to be repeated.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    A long-term epigenetic memory switch controls bacterial virulence bimodality

    Irine Ronin, Naama Katsowich ... Nathalie Q Balaban
    Hysteretic switching between virulence states has been observed in a human pathogen.
    1. Evolutionary Biology

    High potency of sequential therapy with only β-lactam antibiotics

    Aditi Batra, Roderich Roemhild ... Hinrich Schulenburg
    Sequential therapy with only β-lactam antibiotics achieves surprisingly high potency by exploiting both low rates of spontaneous resistance emergence and low rates of spontaneous cross-resistance among the drugs in sequence.
    1. Structural Biology and Molecular Biophysics

    Regulatory switch at the cytoplasmic interface controls TRPV channel gating

    Lejla Zubcevic, William F Borschel ... Seok-Yong Lee
    C-terminal domain of thermoTRPV channels regulates channel gating at the cytoplasmic interface through a switch-like process.
    1. Cell Biology
    2. Computational and Systems Biology

    Bistability of a coupled Aurora B kinase-phosphatase system in cell division

    Anatoly V Zaytsev, Dario Segura-Peña ... Ekaterina L Grishchuk
    Self-activating Aurora B kinase, opposed by an inhibitory phosphatase, forms spatial phosphorylation patterns during cell division.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    How subtle changes in 3D structure can create large changes in transcription

    Jordan Yupeng Xiao, Antonina Hafner, Alistair N Boettiger
    Promoter futile cycles can explain how subtle differences in genome folding sometimes generate large difference in gene expression.
    1. Structural Biology and Molecular Biophysics

    The mechanism of mammalian proton-coupled peptide transporters

    Simon M Lichtinger, Joanne L Parker ... Philip C Biggin
    The manner in which protons control the conformational behaviour of mammalian peptide transporters is revealed through state-of-the-art molecular dynamics simulations supported by cell-based assays.
    1. Biochemistry and Chemical Biology

    Imaging and energetics of single SSB-ssDNA molecules reveal intramolecular condensation and insight into RecOR function

    Jason C Bell, Bian Liu, Stephen C Kowalczykowski
    Individual SSB-ssDNA complexes undergo reversible condensation and de-condensation that is modulated by RecOR during recombination.
    1. Ecology
    2. Evolutionary Biology

    The evolution of distributed sensing and collective computation in animal populations

    Andrew M Hein, Sara Brin Rosenthal ... Iain D Couzin
    A computational model shows that natural selection can cause populations to evolve a distinctive population-level phenotype: the ability to transition between collective states in response to the environment.

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