To protect their food and themselves against detrimental mould fungi, the eggs of a wasp species synthesize and emit remarkable amounts of gaseous nitrogen oxides that are highly effective antimicrobials.
Engineered mesenchymal stem cells (MSCs) could produce mutant β-galactosidase and trigger nitric oxide (NO) release when the NO prodrug is systemically administered, which can achieve NO release in a precise spatiotemporal manner and augment the therapeutic efficiency of MSCs.
Benjamin G Horst, Adam L Yokom ... Michael A Marletta
The full-length structures of the mammalian nitric oxide receptor reveal the molecular activation steps and a binding site for the prototype of FDA-approved stimulators.
Filomena Caccavale, Giovanni Annona ... Salvatore D'Aniello
Previously undescribed morphogenetic and developmental mechanisms unravel that the cooperation of two ancient signaling pathways, nitric oxide and retinoic acid, is essential to build a chordate embryo.
Two neuropeptides, NPF1a and NPF2, act via the nitric oxide signaling pathway in the locust brain to regulate the trait transition between solitary and swarming behavior.
Loss of an amino acid transporter and tissue depletion of nitric oxide worsens the intestinal function of CF mice, a finding that potentially explains variation in disease severity amongst CF individuals.