51 results found
    1. Cancer Biology

    Salicylate, diflunisal and their metabolites inhibit CBP/p300 and exhibit anticancer activity

    Kotaro Shirakawa, Lan Wang ... Eric Verdin
    Salicylic acid, the precursor to aspirin, is an anti-tumor agent that blocks protein acetylation.
    1. Neuroscience

    Tinnitus and hyperacusis involve hyperactivity and enhanced connectivity in auditory-limbic-arousal-cerebellar network

    Yu-Chen Chen, Xiaowei Li ... Gao-Jun Teng
    A comprehensive battery of behavioral, electrophysiological and functional MRI techniques has allowed the development of a data-driven conceptual model of the tinnitus-hyperacusis network.
    1. Medicine
    2. Microbiology and Infectious Disease

    Gut microbiota induces high platelet response in patients with ST segment elevation myocardial infarction after ticagrelor treatment

    Xi Zhang, Xiaolin Zhang ... Yaling Han
    After myocardial infarction, gut microbiota affects platelet aggregation rate by regulating the absorption and metabolism of ticagrelor.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Macroscopic control of cell electrophysiology through ion channel expression

    Mario García-Navarrete, Merisa Avdovic ... Krzysztof Wabnik
    A combination of mathematical modeling and live-cell imaging reveals a strategy for the rational control over cell electrophysiology though modulation of ion channel expression.
    1. Biochemistry and Chemical Biology

    Discovery of the 1-naphthylamine biodegradation pathway reveals a broad-substrate-spectrum enzyme catalyzing 1-naphthylamine glutamylation

    Shu-Ting Zhang, Shi-Kai Deng ... Ning-Yi Zhou
    Elucidating the 1-naphthylamine degradation pathway in Pseudomonas sp. strain JS3066 and analyzing the catalytic mechanism of the 1-naphthylamine glutamine synthetase deepens the understanding of microbial degradation of polycyclic aromatic amines.
    1. Structural Biology and Molecular Biophysics

    Folding of prestin’s anion-binding site and the mechanism of outer hair cell electromotility

    Xiaoxuan Lin, Patrick R Haller ... Tobin R Sosnick
    Identification of Cl-induced folding advances the field’s understanding of prestin’s unique voltage-sensing mechanism and its involvement in mammalian hearing sensation.
    1. Plant Biology

    Prioritizing plant defence over growth through WRKY regulation facilitates infestation by non-target herbivores

    Ran Li, Jin Zhang ... Yonggen Lou
    A chewing herbivore induced WRKY transcription factor induces jasmonate-dependent defences and supresses gibbererellin-dependent growth, the latter of which renders rice plants more susceptible to secondary infestation by a piercing-sucking herbivore.
    1. Neuroscience

    Feedback inhibition and its control in an insect olfactory circuit

    Subhasis Ray, Zane N Aldworth, Mark A Stopfer
    Electrophysiological recordings and a large-scale biophysical model show that a unique inhibitory neuron plays a central role in structuring olfactory codes in the insect brain.
    1. Neuroscience

    Local projections of layer Vb-to-Va are more prominent in lateral than in medial entorhinal cortex

    Shinya Ohara, Stefan Blankvoort ... Menno P Witter
    The connection from layer Vb-to-Va neurons, a key component of the canonical hippocampal-cortical output circuit, which is allegedly crucial for memory consolidation, is relatively stronger in lateral entorhinal cortex compared with the medial entorhinal cortex, thus suggesting different operating principles.
    1. Neuroscience

    A projectome of the bumblebee central complex

    Marcel Ethan Sayre, Rachel Templin ... Stanley Heinze
    Serial-section electron microscopy uncovers the intricate neural network of the bumblebee central complex, revealing highly conserved projection patterns as well as novel circuit elements potentially unique to bees.

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