421 results found
    1. Neuroscience

    Presynaptic stochasticity improves energy efficiency and helps alleviate the stability-plasticity dilemma

    Simon Schug, Frederik Benzing, Angelika Steger
    Presynaptic plasticity in simulated neural networks with a simple biologically plausible learning rule improves metabolic efficiency and lifelong learning capabilities.
    1. Computational and Systems Biology
    2. Developmental Biology

    Stochasticity in the miR-9/Hes1 oscillatory network can account for clonal heterogeneity in the timing of differentiation

    Nick E Phillips, Cerys S Manning ... Nancy Papalopulu
    Stochasticity introduced computationally into a gene expression oscillator creates heterogeneity in the time of differentiation of identical cells and offers robustness to the progenitor state and the outcome of cell division.
    1. Cell Biology
    2. Immunology and Inflammation

    Transiently heritable fates and quorum sensing drive early IFN-I response dynamics

    Laura C Van Eyndhoven, Vincent PG Verberne ... Jurjen Tel
    Early IFN-I response dynamics are initiated in only fractions of cells, of which their epigenetic profile is transiently heritable and subject to the effects of quorum sensing.
    1. Microbiology and Infectious Disease

    Stochastic variation in the initial phase of bacterial infection predicts the probability of survival in D. melanogaster

    David Duneau, Jean-Baptiste Ferdy ... Nicolas Buchon
    An analysis of within-host bacterial proliferation reveals that minor "stochastic" variation in the ability of the innate immune response to control bacterial growth early on can result in either survival or death of the host.
    1. Developmental Biology

    Ordered patterning of the sensory system is susceptible to stochastic features of gene expression

    Ritika Giri, Dimitrios K Papadopoulos ... Richard W Carthew
    How gene expression noise is regulated is critical for cell fate and tissue patterning.
    1. Neuroscience
    2. Physics of Living Systems

    Elements of a stochastic 3D prediction engine in larval zebrafish prey capture

    Andrew D Bolton, Martin Haesemeyer ... Florian Engert
    Zebrafish implement a stochastic recursive algorithm during prey capture that reflects an implicit physical model of the world.
    1. Physics of Living Systems

    Stochastic yield catastrophes and robustness in self-assembly

    Florian M Gartner, Isabella R Graf ... Erwin Frey
    Fluctuations in the availability of particles for binding can completely jeopardize yield in heterogeneous self-assembly.
    1. Microbiology and Infectious Disease

    Extreme heterogeneity of influenza virus infection in single cells

    Alistair B Russell, Cole Trapnell, Jesse D Bloom
    Single-cell mRNA sequencing shows that the impact of infection with influenza virus varies dramatically from one cell to another.
    1. Microbiology and Infectious Disease

    Host Defense: Are we immune by chance?

    Andrea L Graham, Ann T Tate
    The sooner the immune system launches, the greater the chances the host has of survival.
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