1,570 results found
    1. Chromosomes and Gene Expression

    A synthetic biology approach to probing nucleosome symmetry

    Yuichi Ichikawa, Caitlin F Connelly ... Paul D Kaufman
    A novel system for expression of asymmetric nucleosomes in vivo enables mechanistic studies on histone modification readouts in the cell.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Analyzing native membrane protein assembly in nanodiscs by combined non-covalent mass spectrometry and synthetic biology

    Erik Henrich, Oliver Peetz ... Nina Morgner
    As the function of membrane proteins is often influenced by its membrane environment the presented combinatorial approach is of great value for the investigation of membrane protein complexes in natural or even manipulated lipid bilayers.
    1. Biochemistry and Chemical Biology
    2. Plant Biology

    A new synthetic biology approach allows transfer of an entire metabolic pathway from a medicinal plant to a biomass crop

    Paulina Fuentes, Fei Zhou ... Ralph Bock
    A combination of chloroplast transformation with nuclear transformation and large-scale metabolic screening of supertransformed plant lines has enabled an entire biochemical pathway to be transferred from a medicinal plant to a high-biomass crop.
    1. Ecology

    Point of View: A transatlantic perspective on 20 emerging issues in biological engineering

    Bonnie C Wintle, Christian R Boehm ... William J Sutherland
    Horizon scanning has been used to identify opportunities and risks presented by 20 emerging issues in the field of biological engineering.
    1. Computational and Systems Biology

    Engineering of a synthetic quadrastable gene network to approach Waddington landscape and cell fate determination

    Fuqing Wu, Ri-Qi Su ... Xiao Wang
    A synthetic quadrastable gene network provides a synthetic biology framework to study cell fate determination.
  1. Philosophy of Biology: From primal scenes to synthetic cells

    Hub Zwart
    Philosophy may help to explore the potential impacts of synthetic cells.
    1. Cell Biology
    2. Computational and Systems Biology

    De novo-designed minibinders expand the synthetic biology sensing repertoire

    Zara Y. Weinberg, Sarah S. Soliman ... Hana El-Samad
    1. Developmental Biology

    Addressing the ethical issues raised by synthetic human entities with embryo-like features

    John Aach, Jeantine Lunshof ... George M Church
    Guidelines governing research into embryos need to be updated in a way that reflects the moral status of synthetic human entities generated using the methods of synthetic biology.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Light-inducible protein degradation in E. coli with the LOVdeg tag

    Nathan Tague, Cristian Coriano-Ortiz ... Mary J Dunlop
    The LOVdeg tag is a versatile tool for bacterial optogenetics, offering modular, blue light-inducible protein degradation for a range of synthetic biology and metabolic engineering applications.
    1. Ecology
    2. Chromosomes and Gene Expression

    Emerging Technology: Concerning RNA-guided gene drives for the alteration of wild populations

    Kevin M Esvelt, Andrea L Smidler ... George M Church
    Combining CRISPR/Cas9 genome editing with gene drives may enable scientists to reversibly edit the genomes of diverse wild populations, an advance that could help eliminate diseases, support sustainable agriculture, and control invasive species.

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