In transgenesis assays involving diploid model organisms, two clearly distinguishable transformation markers embedded in interweaved, but incompatible Lox site pairs allow the systematic creation of homozygous transgenic lines and minimize the number of wasted animals.

Experiments using zebrafish identify a novel sleep-promoting neuronal circuit in which hypothalamic NPVF neurons promote sleep via the hindbrain serotonergic raphe nuclei, which promote sleep in both zebrafish and mice.

In a mouse model of neurodegeneration, hippocampal firing sequences that normally encode spatial memories become disengaged from external space.

A transgenic small hairpin RNA can provide a viable tool for enhancing resistance to viral infection in livestock and improve animal well-being.

A new method that will allow researchers to visualize and genetically manipulate synaptically connected neurons in a brain circuit.

A novel transgenic lipid droplet reporter in transparent casper zebrafish allows direct visualization of individual lipid droplets in a living animal.

Brain imaging and behavioral analysis reveal two opposing states of hunger, represented by anti-correlated lateral and caudal hypothalamic dynamics that are important for the homeostatic control of feeding in zebrafish.

A commonly used immunoglobulin loci-transgenic mouse, the Kymouse, has B cells that go through complete development and have receptor repertoires that show key differences in encoding gene frequencies but structural similarity in their most variable regions.

Two anatomically and genetically distinct subtypes of spinal V2b neurons provide inhibition onto motor circuits and serve as a brake on locomotor speed.

Transgenic expression of glucanase, xylanase and phytase in pigs enhances growth performance and reduces nitrogen/phosphorus emission, and offers a very valuable biological strategy for sustainable resource utilization and environmental protection in the pork industry.