3,679 results found
    1. Developmental Biology

    A minimally sufficient model for rib proximal-distal patterning based on genetic analysis and agent-based simulations

    Jennifer L Fogel et al.
    Specification and expansion during rib development is explained by Agent-Based Modeling while respecting the locality of decision-making that occurs as millions of cells coordinate their behavior to form and refine spatial pattern.
    1. Developmental Biology
    2. Evolutionary Biology

    A shift in anterior–posterior positional information underlies the fin-to-limb evolution

    Koh Onimaru et al.
    A shift in antero-posterior positional information may contribute to the fin-to-limb transformation.
    1. Cell Biology
    2. Neuroscience

    Adaptation to constant light requires Fic-mediated AMPylation of BiP to protect against reversible photoreceptor degeneration

    Andrew T Moehlman et al.
    Tuning of BiP activity by Fic-mediated AMPylation is required for Drosophila photoreceptor plasticity and attenuation of the unfolded protein response.
    1. Structural Biology and Molecular Biophysics

    PIE-scope, integrated cryo-correlative light and FIB/SEM microscopy

    Sergey Gorelick et al.
    The PIE-scope resolves the limitations in correlative cryo-focused ion beam milling by adding robustness and ease of use to the workflow.
    1. Cell Biology
    2. Neuroscience

    Enhanced FIB-SEM systems for large-volume 3D imaging

    C Shan Xu et al.
    Complete neuronal circuits can be reconstructed, and whole eukaryotic cells imaged, at less than 10 nm isotropic resolution.
    1. Stem Cells and Regenerative Medicine

    Transient inflammatory response mediated by interleukin-1β is required for proper regeneration in zebrafish fin fold

    Tomoya Hasegawa et al.
    The Interleukin 1 beta signaling and tissue inflammation act as a double-edged sword: they are required for regeneration, but when in excess, they impair tissue regeneration and induce apoptosis.
    1. Physics of Living Systems
    2. Computational and Systems Biology

    Probing protein flexibility reveals a mechanism for selective promiscuity

    Nicolas A Pabon, Carlos J Camacho
    Conserved contacts on cognate ligands trigger an induced fit pathway that confers selective promiscuity to PD-1, a flexible regulatory protein and promising anticancer target.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Single-molecule FRET unveils induced-fit mechanism for substrate selectivity in flap endonuclease 1

    Fahad Rashid et al.
    Structure specific nucleases that act in DNA replication, repair and recombination actively mold their DNA while transforming their own structure to achieve precise cleavage of their cognate DNA and avoid the deleterious cleavage of noncognate DNA.
    1. Stem Cells and Regenerative Medicine

    Sox9+ messenger cells orchestrate large-scale skeletal regeneration in the mammalian rib

    Stephanie T Kuwahara et al.
    Large-scale skeletal regeneration requires Hh signaling in Sox9+ lineage cells to coordinate callus formation and bone repair.
    1. Structural Biology and Molecular Biophysics

    Microtubule assembly governed by tubulin allosteric gain in flexibility and lattice induced fit

    Maxim Igaev, Helmut Grubmüller
    A new combined mechanism explains how GTP binding by tubulin is linked to its dynamics and energetics in solution and why GTP-induced flexibility, and not the tubulin conformation as such, drives microtubule assembly.

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