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Teaching a tactile alphabet to sighted adults reveals the brain’s unexpected potential for change.

Foxb1-expressing hypothalamic neurons in the parvafox nucleus and the dorsal premammillary nucleus both contribute to behavioral and physiological components associated with defensive behavior.

A novel model is presented that reconciles in-cell structure probing data with splicing regulatory elements to predict exon 10 inclusion of the Tau gene with high accuracy for 53 splice altering mutations.

Caveolae regulate integrin mechanosensing by establishing a force threshold for activation and recycling.

The ability to discriminate highly overlapping events in memory is a multistage process supported by a network of brain regions and neocortical–hippocampal interactions.

A novel and distinct cholecystokinin brain circuit critically modulates food intake and body weight.

Live imaging and physical perturbations of spindles with unfocused poles reveal that mammalian spindle length emerges locally from kinetochore-fibers, but that global cues from focused spindle poles are needed to coordinate k-fibers across space and time and accurately segregate chromosomes.

A panel of seven new mouse strains with chromosomal duplications is used to identify a minimal genetic region required in three copies to cause congenital heart defects typical of human Down syndrome.

In response to proteotoxic stress, squamous cell carcinoma cells hijack the integrated stress response to promote recovery by bolstering protection of microtubule dynamics.

Retrograde signaling activates the Rad53 checkpoint kinase independently of the canonical DNA replication stress response.