12,632 results found
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structure of the yeast TREX complex and coordination with the SR-like protein Gbp2

    Yihu Xie, Bradley P Clarke ... Yi Ren
    Cryo-EM and chemical cross-linking studies yield an atomic resolution structure of a conserved remodeling machinery in messenger ribonucleoprotein maturation/nuclear export and insights into its coordinated function with a serine–arginine protein.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structure of the CBC-ALYREF complex

    Bradley P Clarke, Alexia E Angelos ... Yi Ren
    Structural studies reveal the mechanism by which the mRNA nuclear export machinery engages with nascent transcripts through interaction with the cap binding complex.
    1. Developmental Biology

    Coronary blood vessels from distinct origins converge to equivalent states during mouse and human development

    Ragini Phansalkar, Josephine Krieger ... Kristy Red-Horse
    Endothelial cells from separate cardiac lineages start off in distinct transcriptional states, but over the course of development converge into transcriptional and functional states which are unrelated to lineage and which are conserved between mouse and human.
    1. Cancer Biology
    2. Immunology and Inflammation

    Proliferative exhausted CD8+ T cells exacerbate long-lasting anti-tumor effects in human papillomavirus-positive head and neck squamous cell carcinoma

    Danni Cheng, Ke Qiu ... Jianjun Ren
    Multi-omic profiling of tumor-infiltrating T cells provides new insights into the differences in the effectiveness of CDK4 inhibitor between human papillomavirus (HPV)-positive and HPV-negative head and neck squamous cell carcinoma patients.
    1. Cell Biology

    Transdifferentiation of fibroblasts into muscle cells to constitute cultured meat with tunable intramuscular fat deposition

    Tongtong Ma, Ruimin Ren ... Heng Wang
    Efficient myogenic and lipogenic transdifferentiation of chicken fibroblasts in 3D culture produces meat with precisely controlled levels of intramuscular fat and extracellular matrix.
    1. Neuroscience

    Large depth differences between target and flankers can increase crowding: Evidence from a multi-depth plane display

    Samuel P Smithers, Yulong Shao ... Peter J Bex
    Visual crowding from clutter outside the limits of binocular fusion can still have a significant impact on object recognition and visual perception in the peripheral field.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural and biochemical analyses of the DEAD-box ATPase Sub2 in association with THO or Yra1

    Yi Ren, Philip Schmiege, Günter Blobel
    Biochemical and structural analyses of a universal mRNP remodeling pathway suggest an ATPase-powered targeted deposition of export factors onto mRNP.
    1. Developmental Biology
    2. Genetics and Genomics

    GLI transcriptional repression regulates tissue-specific enhancer activity in response to Hedgehog signaling

    Rachel K Lex, Zhicheng Ji ... Steven A Vokes
    GLI3 represses Hedgehog target gene expression by regulating histone modifications at a subset of tissue-specific GLI-bound enhancers.
    1. Genetics and Genomics

    Genome-wide association study in quinoa reveals selection pattern typical for crops with a short breeding history

    Dilan SR Patiranage, Elodie Rey ... Christian Jung
    A new insight into quinoa diversity enables sequence-based breeding and functional genomics.
    1. Genetics and Genomics
    2. Stem Cells and Regenerative Medicine

    A multiplexed, single-cell sequencing screen identifies compounds that increase neurogenic reprogramming of murine Muller glia

    Amy Tresenrider, Marcus Hooper ... Thomas A Reh
    An in vitro chemical screen with single-cell sequencing output leads to the identification of Metformin as an in vivo enhancer of Muller glia to neuron reprogramming in mice.

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