Activation of the key regulator of cytokinesis, RhoA, involves an unexpected contribution by a RhoGAP domain.

Optogenetic activation of Rho GTPases provides spatiotemporal control over endothelial cell shape and enables control over endothelial barrier function by manipulating the cell-cell overlap with blue light.

PDZ-RhoGEF controls adipose tissue abundance and whole body metabolism.

Embryoid bodies produce diverse cell types and can enable the study of gene regulatory dynamics at unprecedented spatial and temporal resolution.

Diverse sophisticated phylogenetic analyses update the phylogeny of the Alphaproteobacteria and show that the parasitic Holosporales is a derived group within the Rhodospirillales order which comprises primarily free-living alphaproteobacteria.

The RhoGTPase domain containing protein GRAF recruits to the cleavage furrow during myosin II assembly to hydrolyze Rho-GTP and restrict actomyosin contractility for regulating the time of onset of constriction during Drosophila cellularization.

A number of microbial eukaryotes have adapted to low oxygen conditions by acquiring a gene that allows their mitochondrial electron transport chain to continue to function when oxygen is scarce.

The major cytosolic yeast peroxiredoxin Tsa1 controls aging and H₂O₂-resistance by inhibiting protein kinase A through a conserved cysteine in the catalytic subunit activation loop and not by scavenging H₂O₂.

The mechanism underlying Shprintzen–Goldberg syndrome is solved and reveals that missense mutations in the transcriptional repressor SKI abolish ligand-induced SKI degradation, which results in attenuation of TGF-β transcriptional responses.

Identification of a new family of stress-induced plant signalling peptides and their cognate receptor.