The identification of key determinants of LSC “stemness” and LSC differentiation that is reversible through an epigenetic mechanism may have considerable implications in understanding leukemia and designing effective therapies.

Machine learning-assisted experiments reveal CD81 as a novel binding partner of CD44 in driving cancer stemness, tumor cell clustering, and extracellular vesicle integrity in human and mouse breast cancer.

The expression of the major circadian component CLOCK is a key regulator of stemness in breast cancer cells, which can be a novel strategy for breast cancer treatment.

Stem-cell-specific transcriptional repressors fine-tune levels of stemness gene transcripts in asymmetrically dividing neural stem cells by depositing low levels of repressive histone marks at these loci allowing progeny to rapidly initiate differentiation.

Learning in children with autism spectrum disorder (ASD) was achieved by fundamentally different cognitive and neural mechanisms from typically developing children, and insistence on sameness, a core symptom of ASD, contributed to such atypical mechanisms of learning in affected children.

Nicotine affects intestinal stem cells rather than Paneth cells, resulting in the increased stemness and tumorigenicity of intestinal stem cells.

The occurrence, progression and treatment of cancer may be linked to changes in the nature of stemness.

Mice studies show that the 'just-right' balance optimal for BRAF^V600E-induced cecal tumor formation can be achieved through FAK alteration.

Repressing the conserved pro-differentiation let-7 microRNAs through limiting Ago2 levels is critical to maintaining pluripotency in stem cells.