The interaction between activated αIIbβ3 on platelets and SLC44A2 on circulating neutrophils facilitates neutrophil capture and drives flow-dependent NETosis.

The genetic make-up of dominating MDR-TB clades in Central Asia is shaped by programmatic and socio-economic changes that led to fixation of resistance and bacterial fitness related mutations in the Soviet era.

Sertraline, a widely used antidepressant, enhances the potency of the standard antimycobacterial therapy in preclinical models of TB infection.

Low-burden does not mean low local transmission, and tailor-made strategies are needed to control TB based on the knowledge of the local transmission dynamics.

PLC-γ isozymes are activated by a combination of receptor engagement and membrane proximity.

Penetration of the fluoroquinolones in tuberculosis lesions is heterogeneous even in fully cellular areas, is driven by macrophage content and decreases as the distance from lesion outer rim increases.

Mycobacterium tuberculosis exploits an IFN/IL6/CEBP axis linked to monocyte expansion in humans.

Incorporating within-host diversity in transmission, as identified by deep sequencing, can significantly change previously-held inferences, with major implications for genomic studies of transmission in tuberculosis and other pathogens as well.

The interplay of nitric oxide and dopamine specialize one memory unit in a fly brain in predicting the value of odors based only on recent experience.

Systemic inflammation is greater in individuals with concurrent TB and diabetes than in euglycemic individuals with TB, and this disparity persists through the full 6-month course of anti-tubercular treatment.