New technology for manipulating genes in Drosophila facilitates gene tagging and precise modification of virtually any gene.

Optimization of homology donor DNA production and integration schemes facilitates homologous recombination in vivo and in cell culture in Drosophila melanogaster..

Systematic analysis of C. elegans zygotes manipulated to divide equally demonstrates that daughter cell size asymmetry is critical for proper cell cycle timing, positioning, and fates during subsequent embryogenesis.

New construct designs and gene targeting strategies from the Gene Disruption Project allow efficient tagging of almost all Drosophila genes.

A modified viral strategy reveals that ventral tegmental area dopamine cells receive substantial inputs from local sources, including distributed GABAergic and serotonergic inputs from the midbrain as well as extensive inputs from other midbrain dopamine cells.

A novel methodical approach aimed at improving translation of network analyses to psychopathology provides an intuitive representation of longitudinal clinical pathways between symptoms and can assist in predicting prognosis.

Paranoia is underwritten by variation in prior beliefs about how the world will change and how to learn from those changes.

Combined genetic experiments and cellular trafficking assays in Drosophila and mammalian models uncover a new role of RAS-like GTPases in EGFR signalling activation during tissue regeneration and tumourigenesis through regulation of EGFR internalisation.

A conditional gene inactivation system that permits the tracking of protein expression, and creates fluorescently-labelled mutant cells in both developing and adult Drosophila tissues.

The unexpected absence of danger is experienced as a pleasurable relief and activates reward-related brain regions in humans, highlighting an overlap in the processing of absent danger and rewards.