Open-top Bessel beam two-photon light sheet microscopy have the potential for rapid and accurate nondestructive pathology by visualizing 3D histological information.

Improved two-photon fluorescence microendoscopy enables volumetric imaging of synapses and neurons in deep brain structures in vivo.

A novel single-objective light-sheet microscope with unparalleled spatiotemporal resolution enables imaging and optical manipulation of diverse biological specimens and processes.

Neutrophil pseudopods are composed of multiple sheets that are inherently flat, protrude in three dimensions, and whose assembly correlates with cell turning.

Optogenetic tools enable sophisticated measurements of a voltage-gated sodium channel implicated in pain, as well as high-throughput screening of candidate channel blockers.

Phase contrast X-ray tomography based on a combination of parallel and cone beam geometry extends conventional histology by a third dimension and enables full quantication of tissue remodeling in COVID-19.

DExCon, LUXon, and DExogron approaches simultaneously block endogenous gene expression and permit tuning of re-expression levels in time and space; proof-of-principle reveals unforeseen differences in protein kinetics, cargo handling, and cell migration regulation between closely related Rab11 family members.

A novel brain circuit that determines how much alcohol a mouse binge drinks by complex control of drinking behavior mechanics is surveyed.

The pressure of fluid in the inner ear is controlled by opening of cellular valves in the endolymphatic sac to allow for regulated transepithelial fluid flow.

The atomic structure of GtACR1 provides new insight into the chemical mechanism of natural light-gated anion membrane conductance, and enables its optimization for optogenetic photoinhibition of neuron firing.