2,140 results found
    1. Evolutionary Biology
    2. Genetics and Genomics

    Attacks on genetic privacy via uploads to genealogical databases

    Michael D Edge, Graham Coop
    Direct-to-consumer genetic genealogy services that allow users to upload their own datasets are vulnerable to attacks on genetic privacy that exploit the structure of genetic variation.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Insights into herpesvirus assembly from the structure of the pUL7:pUL51 complex

    Benjamin G Butt, Danielle J Owen ... Stephen C Graham
    A conserved viral protein complex that promotes membrane wrapping of nascent herpesvirus particles shows structural similarity to cellular membrane-remodelling proteins, suggesting functional mimicry.
    1. Medicine
    2. Microbiology and Infectious Disease

    Efficacy of ultra-short, response-guided sofosbuvir and daclatasvir therapy for hepatitis C in a single-arm mechanistic pilot study

    Barnaby Flower, Le Manh Hung ... Graham S Cooke
    Shortened hepatitis C therapy, with retreatment if needed, can reduce antiviral drug use in patients with mild liver disease, but day 2 viral load is not an adequate predictor of outcome.
    1. Stem Cells and Regenerative Medicine

    Brahma is essential for Drosophila intestinal stem cell proliferation and regulated by Hippo signaling

    Yunyun Jin, Jinjin Xu ... Lei Zhang
    The Brahma chromatin remodelling complex interacts with the Hippo signalling pathway to regulate the proliferation and differentiation of stem cells in the Drosophila midgut.
    1. Immunology and Inflammation

    Analysis of combinatorial chemokine receptor expression dynamics using multi-receptor reporter mice

    Laura Medina-Ruiz, Robin Bartolini ... Gerard J Graham
    The use of multi-chemokine receptor reporter mice helps to unravel the dynamics of receptor involvement in leukocyte migration in vivo and suggests specificity, rather than redundancy, in receptor use.
    1. Neuroscience

    Single-cell RNAseq analysis of spinal locomotor circuitry in larval zebrafish

    Jimmy J Kelly, Hua Wen, Paul Brehm
    Single-cell transcriptomics of larval zebrafish spinal cord reveal ion channels and exocytotic machinery that enhance transmitter release in neuronal types shown to mediate high-speed swimming and escape behavior.
    1. Immunology and Inflammation
    2. Medicine

    Wnt signaling enhances macrophage responses to IL-4 and promotes resolution of atherosclerosis

    Ada Weinstock, Karishma Rahman ... Edward A Fisher
    Wnt signaling is revealed to be a regulator of macrophage inflammation-resolving state in atherosclerosis through a PGE2-mediated pathway.
    1. Neuroscience

    Extinction recall of fear memories formed before stress is not affected despite higher theta activity in the amygdala

    Mohammed Mostafizur Rahman, Ashutosh Shukla, Sumantra Chattarji
    When the fear-enhancing effects of prior exposure to stress are absent, the expression of fear reflects normal neural activity in the medial prefrontal cortex, not stress-induced hyperactivity in the amygdala.
    1. Immunology and Inflammation

    Inhibition of ErbB kinase signalling promotes resolution of neutrophilic inflammation

    Atiqur Rahman, Katherine M Henry ... Lynne R Prince
    Targeting ErbB receptor tyrosine kinases modifies neutrophil survival and inflammation across multiple species, and reveals a new use for ErbB therapeutics in resolving inflammatory disease.
    1. Microbiology and Infectious Disease

    LINE-1 retrotransposons facilitate horizontal gene transfer into poxviruses

    M Julhasur Rahman, Sherry L Haller ... Stefan Rothenburg
    A new experimental system of horizontal gene transfer demonstrates that host retrotransposons facilitate the transfer of host genes into poxviruses.

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