243 results found
    1. Neuroscience

    Loss of ZBTB20 impairs circadian output and leads to unimodal behavioral rhythms

    Zhipeng Qu, Hai Zhang ... Ying Xu
    The zinc finger protein ZBTB20 is a morning and evening activity gating factor in mice.
    1. Physics of Living Systems

    Robust, coherent, and synchronized circadian clock-controlled oscillations along Anabaena filaments

    Rinat Arbel-Goren, Valentina Buonfiglio ... Joel Stavans
    Noisy circadian clocks in Anabaena, coupled by cell-cell communication, display high spatio-temporal coherence and can be robustly described by incorporating demographic noise in a theoretical model of coupled clock arrays.
    1. Plant Biology

    Accurate timekeeping is controlled by a cycling activator in Arabidopsis

    Polly Yingshan Hsu, Upendra K Devisetty, Stacey L Harmer
    The circadian clock in the model plant organism Arabidopsis thaliana is best described as a highly connected network made up of clock-regulated activators and repressors of transcription, rather than two coupled, repressor-based feedback loops.
    1. Cell Biology

    Evidence for a role of human blood-borne factors in mediating age-associated changes in molecular circadian rhythms

    Jessica E Schwarz, Antonijo Mrčela ... Amita Sehgal
    Blood-borne factors contribute to changes in the circadian transcriptome with age.
    Version of Record
    Short Report
    • Fundamental
    • Compelling
    1. Chromosomes and Gene Expression
    2. Neuroscience

    Acetylation of BMAL1 by TIP60 controls BRD4-P-TEFb recruitment to circadian promoters

    Nikolai Petkau, Harun Budak ... Gregor Eichele
    Acetylation of the circadian transcription factor BMAL1 by the acetyltransferase TIP60 is crucial for recruitment of the pause release factors to clock gene promoters and productive elongation of these genes.
    1. Neuroscience

    Differential regulation of the Drosophila sleep homeostat by circadian and arousal inputs

    Jinfei D Ni, Adishthi S Gurav ... Craig Montell
    Functional imaging and circuit mapping in the Drosophila brain identifies neuropils where sleep-promoting and arousal-promoting neuronal networks converge.
    1. Neuroscience

    Neurocalcin regulates nighttime sleep and arousal in Drosophila

    Ko-Fan Chen, Simon Lowe ... James Jepson
    The neuronal calcium sensor Neurocalcin regulates sleep and arousal thresholds during the night in Drosophila.
    1. Genetics and Genomics
    2. Neuroscience

    Zinc finger homeobox-3 (ZFHX3) orchestrates genome-wide daily gene expression in the suprachiasmatic nucleus

    Akanksha Bafna, Gareth Banks ... Patrick M Nolan
    A multiomic study reveals the role of ZFHX3 transcription factor in daily timekeeping with a combination of transcription factor and histone ChIP-seq and time-resolved RNA-seq in the mammalian central clock.
    1. Genetics and Genomics
    2. Neuroscience

    Neural mechanisms of parasite-induced summiting behavior in ‘zombie’ Drosophila

    Carolyn Elya, Danylo Lavrentovich ... Benjamin de Bivort
    In zombie fruit flies, Entomophthora muscae-elicited summiting behavior is mediated by blood-borne factors and the host circadian-neurosecretory network.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Switching of metabolic programs in response to light availability is an essential function of the cyanobacterial circadian output pathway

    Anna M Puszynska, Erin K O'Shea
    The circadian clock of Synechococcus elongatus PCC7942 schedules the activity of the transcription factor RpaA, which controls key events in carbon metabolism that contribute to cell fitness in conditions mimicking the natural environment.

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