249 results found
    1. Computational and Systems Biology
    2. Physics of Living Systems

    How microscopic epistasis and clonal interference shape the fitness trajectory in a spin glass model of microbial long-term evolution

    Nicholas M Boffi, Yipei Guo ... Ariel Amir
    High-resolution simulations of evolving microbial populations reveal that microscopic epistasis slows the rate of adaptation, while clonal interference can either speed it up or leave it fixed.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Parallel evolution of influenza across multiple spatiotemporal scales

    Katherine S Xue, Terry Stevens-Ayers ... Jesse D Bloom
    Influenza evolution within infected hosts recapitulates many evolutionary dynamics observed at the global scale.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Reversions mask the contribution of adaptive evolution in microbiomes

    Paul A Torrillo, Tami D Lieberman
    The timescale dependence of dN/dS in bacteria is better explained by adaptive than purifying dynamics, suggesting comparative genomics can underestimate past adaptation.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Eco-evolutionary dynamics of adapting pathogens and host immunity

    Pierre Barrat-Charlaix, Richard A Neher
    Diverse histories of viral exposure, for example in individuals of different age, makes viral evolution less predictable with features of adaptive and neutral evolution.
    1. Evolutionary Biology

    Adaptation dynamics between copy-number and point mutations

    Isabella Tomanek, Călin C Guet
    In bacteria, frequent adaptive copy-number mutations can hinder the fixation of beneficial point mutations and hence the divergence of duplicated DNA sequences.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Most cancers carry a substantial deleterious load due to Hill-Robertson interference

    Susanne Tilk, Svyatoslav Tkachenko ... Christopher D McFarland
    The absence of negative selection observed in most cancer genomes can be explained by the intrinsic genome-wide linkage in somatic evolution and creates a substantial proteotoxic load.
    1. Evolutionary Biology

    Selection on mutators is not frequency-dependent

    Yevgeniy Raynes, Daniel Weinreich
    Contrary to intuition that the evolutionary fate of mutation rate modifying alleles is frequency-dependent, neither the strength nor the sign of selection on modifiers depends on initial frequency.
    1. Epidemiology and Global Health

    The effects of a deleterious mutation load on patterns of influenza A/H3N2's antigenic evolution in humans

    Katia Koelle, David A Rasmussen
    Deleterious mutations slow down flu's antigenic evolution, make it more punctuated in nature, and reduce the virus's genetic diversity.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Repeated origins, widespread gene flow, and allelic interactions of target-site herbicide resistance mutations

    Julia M Kreiner, George Sandler ... Stephen I Wright
    The spread of herbicide resistance in one of the most problematic weeds in North America occurs through both recent, repeated mutational origins and gene flow across an international network of agricultural fields.
    1. Developmental Biology
    2. Neuroscience

    Cell type composition and circuit organization of clonally related excitatory neurons in the juvenile mouse neocortex

    Cathryn R Cadwell, Federico Scala ... Andreas Savas Tolias
    Excitatory cortical neurons with a shared developmental lineage are transcriptomically diverse and preferentially connect to each other vertically, across cortical layers, but not laterally within the same layer.

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