1,420 results found
    1. Evolutionary Biology

    Genetic transformation of Spizellomyces punctatus, a resource for studying chytrid biology and evolutionary cell biology

    Edgar M Medina, Kristyn A Robinson ... Nicolas E Buchler
    Spizellomycespunctatusis a genetically tractable chytrid and model organism for comparative cell biology for understanding evolution of the cell cycle, actin dynamics, and cellularization in fungi and early eukaryotes.
    1. Ecology

    Genomic adaptations in information processing underpin trophic strategy in a whole-ecosystem nutrient enrichment experiment

    Jordan G Okie, Amisha T Poret-Peterson ... James J Elser
    Trait-based metagenomic analysis of an ecosystem fertilization experiment shows that genomic traits that affect the costs and rates of biochemical information-processing mediate community assembly.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Single-cell analysis of mosquito hemocytes identifies signatures of immune cell subtypes and cell differentiation

    Hyeogsun Kwon, Mubasher Mohammed ... Ryan C Smith
    Single-cell RNA-seq analysis reveals an increased complexity of mosquito hemocytes, enabling the functional and molecular characterization of immune cell sub-populations in Anopheles gambiae.
    1. Cell Biology

    A cellular and molecular atlas reveals the basis of chytrid development

    Davis Laundon, Nathan Chrismas ... Michael Cunliffe
    Three-dimensional cell modelling, lipid analysis, transcriptomics, and live-cell imaging reveal biological insights in to the key stages of the chytrid fungus life cycle.
    1. Cell Biology
    2. Genetics and Genomics

    Analysis of meiosis in Pristionchus pacificus reveals plasticity in homolog pairing and synapsis in the nematode lineage

    Regina Rillo-Bohn, Renzo Adilardi ... Abby F Dernburg
    Investigation of meiosis in the nematode Pristionchus pacificus has illuminated evolutionary variation in this essential aspect of reproduction and established a new model for future study.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Expanding the MECP2 network using comparative genomics reveals potential therapeutic targets for Rett syndrome

    Irene Unterman, Idit Bloch ... Yuval Tabach
    A novel comparative genomics framework identifies MECP2 network proteins targeted by existing drugs, with three drugs validated in an in vitro Rett syndrome model.
    1. Computational and Systems Biology
    2. Developmental Biology

    The transcriptomic and epigenetic map of vascular quiescence in the continuous lung endothelium

    Katharina Schlereth, Dieter Weichenhan ... Hellmut G Augustin
    The acquisition of vascular quiescence during transition to adulthood is driven by distinct transcriptional and epigenetic programs of pro- and anti-angiogenic genes, with the most prominent effect on the suppression of TGFß family signaling.
    1. Microbiology and Infectious Disease

    A comparative transcriptomic analysis of replicating and dormant liver stages of the relapsing malaria parasite Plasmodium cynomolgi

    Annemarie Voorberg-van der Wel, Guglielmo Roma ... Thierry Tidiane Diagana
    This comprehensive transcriptomic resource of dormant and replicating malaria liver parasites highlights the dearth of pathways that operate in the hypnozoites and the need to investigate druggability (i.e. selectivity and safety) of core pathways in malaria parasites.
    1. Developmental Biology
    2. Evolutionary Biology

    The Natural History of Model Organisms: Amphioxus as a model to study the evolution of development in chordates

    Salvatore D'Aniello, Stephanie Bertrand, Hector Escriva
    Interest in the ecology, biology and evolution of amphioxus is growing, and the availability of several species is helping to improve our understanding of chordate evolution.
    1. Ecology
    2. Evolutionary Biology
    Silhouette of a rhesus macaque on a yellow/orange background.

    The Natural History of Model Organisms: The rhesus macaque as a success story of the Anthropocene

    Eve B Cooper, Lauren JN Brent ... James P Higham
    The rhesus macaque is a non-human primate that is widely used as a model organism in ecology, evolutionary biology and behavioural science.

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