Analysis of a spermiogenesis protein reveals a new chromatin requirement for synchrony between maternal DNA packaged in the egg and sperm-packaged paternal DNA in the first embryonic mitosis in Drosophila melanogaster.

Evolution strictly preserves telomere stability but rapidly diversifies telomere length regulation in Drosophila.

The first epigenetic clock for rats was developed and revealed to reflect phenotypic aging and captured the effects of longevity interventions.

The LIM-homedomain transcription factor Lhx2 confers competence to retinal progenitor cells to activate and maintain Sonic Hedgeghog signaling at physiological levels during a key phase of tissue growth and cell type generation.

Boundary:boundary pairing interactions drive TAD formation in Drosophila.

A photoswitchable pore blocker was covalently attached to a cysteine-substituted glutamate delta 2 receptor, to provide optical control of its ion channel function.

The HCN1 channel gates thanks to a coupling mechanism involving the reorganization of the interfaces between the voltage-sensor domains and pore helices, subtly shifting the balance between hydrophobic and hydrophilic interactions in a 'domino effect'.

Nutrient starvation activates autophagy by a novel signaling mechanism that is blocked by one of the major autophagy inhibitors.

Advanced data analysis of molecular dynamics simulations of complex lipid membranes provides a quantitative and predictive model of the molecular features that control electroporation.

Theoretical modeling reveals how stochastic optimal cancer immune evasion via antigen downregulation gives rise to diverse post-escape cancer antigenic profiles in a manner dependent on the immune microenvironment.