2,463 results found
    1. Developmental Biology
    2. Immunology and Inflammation

    Tissue-resident macrophages promote extracellular matrix homeostasis in the mammary gland stroma of nulliparous mice

    Ying Wang et al.
    A distinct resident macrophage subpopulation that localizes to the adipose stroma and fibrous capsule of the nulliparous mammary gland and to extracellular matrix-enriched stroma surrounding mammary tumors is identified.
    1. Developmental Biology
    2. Immunology and Inflammation

    Estrogen exacerbates mammary involution through neutrophil-dependent and -independent mechanism

    Chew Leng Lim et al.
    Estrogen aggravates mammary involution through lysosome-mediated cell death, neutrophil recruitment via CXCR2 signalling, neutrophil-mediated inflammation and adipocyte repopulation.
    1. Ecology

    Mammal communities are larger and more diverse in moderately developed areas

    Arielle Waldstein Parsons et al.
    Citizen science camera trapping showing suburban and wild areas maintain similar levels of mammalian diversity and relative abundance, challenging conventional thoughts about the impacts of urbanization on wildlife.
    1. Developmental Biology
    2. Cancer Biology

    RUNX1, a transcription factor mutated in breast cancer, controls the fate of ER-positive mammary luminal cells

    Maaike PA van Bragt et al.
    Loss of RUNX1, a key regulator of estrogen receptor-positive luminal breast cells, impairs mammary epithelial differentiation and contributes to luminal breast cancer via genetic interactions with a loss of p53 or RB1.
    1. Stem Cells and Regenerative Medicine

    Paracrine Met signaling triggers epithelial–mesenchymal transition in mammary luminal progenitors, affecting their fate

    Amandine Di-Cicco et al.
    Mammary progenitors identified by a new marker, ICAM-1, undergo epithelial-mesenchymal transition and luminal-to-basal switch in response to paracrine Met activation.
    1. Evolutionary Biology
    2. Neuroscience

    A cerebellar substrate for cognition evolved multiple times independently in mammals

    Jeroen B Smaers et al.
    Multiple independent directional selection events on a neural substrate that underpins domain-general associative abilities partly explains independent occurrences of complex behavior in different lineages of mammals.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Viruses are a dominant driver of protein adaptation in mammals

    David Enard et al.
    Viruses drive adaptation at the scale of the whole proteome and not only in antiviral proteins in mammalian hosts.
    1. Cell Biology

    Peroxisomal lactate dehydrogenase is generated by translational readthrough in mammals

    Fabian Schueren et al.
    Whole-genome in silico screening for stop codon contexts that produce elevated translational readthrough and peroxisome targeting reveals that in mammals, the amount of lactate dehydrogenase in the peroxisome is controlled by translational readthrough.
    1. Neuroscience

    Phylogenetic variation in cortical layer II immature neuron reservoir of mammals

    Chiara La Rosa et al.
    The higher amount of cortical immature neurons in brains with expanded neocortices may represent a reservoir of young cells for mammals with reduced neurogenesis.
    1. Developmental Biology
    2. Evolutionary Biology

    Transient role of the middle ear as a lower jaw support across mammals

    Neal Anthwal et al.
    The incus of the middle ear plays a role in supporting the lower jaw prior to the formation of the mammalian jaw joint allowing early feeding in monotremes and marsupials.

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