While Dectin-1 is a well-known C-type lectin receptor recognizing b-glucan and involved in anti-fungal immunity, human Dectin-1 is O-glycosylated and acts as a ligand for another C-type lectin receptor, CLEC-2, expressed by platelets that mediates homeostatic responses such as lymphangiogenesis.

Plectin drives hepatocellular carcinoma progression and metastasis through cytoskeletal reorganization and oncogenic signaling, making it a promising therapeutic target for overcoming therapy resistance.

The secreted sugar-binding protein galectin-8 causes osteoblasts to secrete factors that promote the differentiation of bone marrow cells into osteoclasts; targeting this protein could therefore potentially help treat diseases associated with excessive bone loss.

Manipulating cell death in situ with the temporal and spatial precision of optogenetic tools opens up new avenues for studying inflammation, death and related phenomena, revealing, for example, that epithelial cell death cannot be classified into strictly distinct categories.

Leptin acts in the paraventricular nucleus to slowly increase sympathetic nerve activity to skeletal muscle and brown adipose tissue via induction of its own receptor in TRH glutamatergic neurons.

Sulforaphane through NRF2-dependent and -independent cellular and molecular pathways alleviates leptin resistance to reverse the diet-induced obesity.

The methylation status of pectin acts as a critical signalling scaffold for RALF peptides, linking extracellular matrix dynamics to peptide hormone-mediated regulation of plant root growth.

An immune system pattern recognition receptor potentiates anti-tumor innate immune responses, offering new insight into anti-tumor activity of the innate immune system.

Small Rho GTPases confer up- and downregulation in mammalian plexin signaling by differential interactions with cell membrane.

An encompassing resource of differentially phosphorylated proteins forms the basis for identifying missing links in cell fate determination and morphogenesis, including, for example, microtubules as mediators of different functions in cells along the dorso-ventral axis.