295 results found
    1. Computational and Systems Biology

    Removing unwanted variation with CytofRUV to integrate multiple CyTOF datasets

    Marie Trussart, Charis E Teh ... Terence P Speed
    CytofRUV is a computational algorithm that effectively enables batch effect reduction in multiple CyTOF batches with an adaptable normalisation method and an R-Shiny application with diagnostics plots.
    1. Developmental Biology

    Placental uptake and metabolism of 25(OH)vitamin D determine its activity within the fetoplacental unit

    Brogan Ashley, Claire Simner ... Jane K Cleal
    Active uptake and metabolism of maternal vitamin D by the placenta determine fetal exposure to vitamin D and how vitamin D regulates the placental transcriptome, which is also determined by its underlying epigenetic landscape, and proteome.
    1. Developmental Biology

    Glucose inhibits cardiac muscle maturation through nucleotide biosynthesis

    Haruko Nakano, Itsunari Minami ... Atsushi Nakano
    During cardiogenesis, the major role of glucose is not the catabolic extraction of energy but the anabolic biosynthesis of nucleotides.
    1. Neuroscience

    Unexplained repeated pregnancy loss is associated with altered perceptual and brain responses to men’s body-odor

    Liron Rozenkrantz, Reut Weissgross ... Noam Sobel
    Women with unexplained miscarriages have an altered behavioral and brain response to men's body-odor, and this may reflect a factor in their condition.
    1. Neuroscience

    Pregnancy Loss: A possible link between olfaction and miscarriage

    Neven Borak, Johannes Kohl
    Unexplained repeated pregnancy loss is associated with an altered perception of male odors and differences in brain regions that process smells.
    Version of Record
    Insight
    1. Neuroscience

    Neural mechanisms of social learning in the female mouse

    Yuan Gao, Carl Budlong ... Ian G Davison
    After mating, female mice form a sensory memory of the stud male's pheromones that correlates with striking changes in responsiveness of the specific neural ensemble activated by her partner.
    1. Neuroscience

    Semiochemical responsive olfactory sensory neurons are sexually dimorphic and plastic

    Aashutosh Vihani, Xiaoyang Serene Hu ... Hiroaki Matsunami
    Semiochemicals activate a subpopulation of sexually dimorphic olfactory sensory neurons.
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    Morphological and genomic shifts in mole-rat ‘queens’ increase fecundity but reduce skeletal integrity

    Rachel A Johnston, Philippe Vullioud ... Jenny Tung
    In cooperatively breeding Damaraland mole-rats, transitioning to 'queen' results in extensive gene regulatory and morphological remodeling, but also costs to skeletal integrity that scale with reproductive investment.
    1. Evolutionary Biology
    2. Medicine

    Developing a theoretical evolutionary framework to solve the mystery of parturition initiation

    Antonis Rokas, Sam Mesiano ... Louis Muglia
    This review considers the evolutionary processes and physiological mechanisms that maintain or end pregnancy in mammals to formulate general, testable theoretical models that provide insights into the biology of parturition.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Evolutionary transcriptomics implicates HAND2 in the origins of implantation and regulation of gestation length

    Mirna Marinić, Katelyn Mika ... Vincent J Lynch
    The transcription factor HAND2 evolved uterine expression during the origins of pregnancy and may be important for maternal-fetal immune signaling and parturition.

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