20,165 results found
    1. Cell Biology
    2. Developmental Biology

    Physically asymmetric division of the C. elegans zygote ensures invariably successful embryogenesis

    Radek Jankele, Rob Jelier, Pierre Gönczy
    Systematic analysis of C. elegans zygotes manipulated to divide equally demonstrates that daughter cell size asymmetry is critical for proper cell cycle timing, positioning, and fates during subsequent embryogenesis.
    1. Neuroscience

    Omissions of threat trigger subjective relief and prediction error-like signaling in the human reward and salience systems

    Anne L Willems, Lukas Van Oudenhove, Bram Vervliet
    The unexpected absence of danger is experienced as a pleasurable relief and activates reward-related brain regions in humans, highlighting an overlap in the processing of absent danger and rewards.
    1. Medicine

    Characterization and prediction of clinical pathways of vulnerability to psychosis through graph signal processing

    Corrado Sandini, Daniela Zöller ... Stephan Eliez
    A novel methodical approach aimed at improving translation of network analyses to psychopathology provides an intuitive representation of longitudinal clinical pathways between symptoms and can assist in predicting prognosis.
    1. Microbiology and Infectious Disease

    Research Culture: Co-reviewing and ghostwriting by early-career researchers in the peer review of manuscripts

    Gary S McDowell, John D Knutsen ... Rebeccah S Lijek
    Early career researchers commonly peer review manuscripts on behalf of invited reviewers, often without receiving feedback or being named to the journal.
    1. Neuroscience

    Paranoia as a deficit in non-social belief updating

    Erin J Reed, Stefan Uddenberg ... Philip R Corlett
    Paranoia is underwritten by variation in prior beliefs about how the world will change and how to learn from those changes.
    1. Medicine
    2. Neuroscience

    The importance of individual beliefs in assessing treatment efficacy

    Luisa Fassi, Shachar Hochman ... Roi Cohen Kadosh
    Participants' subjective beliefs about the treatment received in an intervention study can explain variability in mental health symptoms and cognition.
    1. Neuroscience

    Evidence for dopaminergic involvement in endogenous modulation of pain relief

    Simon Desch, Petra Schweinhardt ... Susanne Becker
    Endogenous modulation of pain relief perception is based on its motivational content and enhanced by increased dopamine availability with no significant effects of a pharmacological opioidergic manipulation in healthy volunteers.
    1. Stem Cells and Regenerative Medicine

    Ecdysone steroid hormone remote controls intestinal stem cell fate decisions via the PPARγ-homolog Eip75B in Drosophila

    Lisa Zipper, Denise Jassmann ... Tobias Reiff
    A systemic hormone controls progenitor fate decisions independent of local fate determining pathways in the adult intestinal stem cell niche of Drosophila melanogaster..
  1. Meta-Research: Large-scale language analysis of peer review reports

    Ivan Buljan, Daniel Garcia-Costa ... Ana Marušić
    The linguistic characteristics of peer review reports are not influenced by research area, type of review or reviewer gender, which is evidence for the robustness of peer review.
    1. Cancer Biology

    FGF2-FGFR1 signaling regulates release of Leukemia-Protective exosomes from bone marrow stromal cells

    Nathalie Javidi-Sharifi, Jacqueline Martinez ... Elie Traer
    Inhibition of FGF2-FGFR1 signaling in bone marrow stroma attenuates secretion of FGF2-laden exosomes and subsequent protection of leukemia cells.

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