111 results found
    1. Developmental Biology
    2. Evolutionary Biology

    Xbp1 and Brachyury establish an evolutionarily conserved subcircuit of the notochord gene regulatory network

    Yushi Wu, Arun Devotta ... Anna Di Gregorio
    Research carried out in the simple chordate Ciona has elucidated the regulatory interplay between two evolutionarily conserved transcription factors, Brachyury and Xbp1, and has shed new light on their roles in the formation of the notochord.
    1. Stem Cells and Regenerative Medicine

    Wnt signaling-mediated redox regulation maintains the germ line stem cell differentiation niche

    Su Wang, Yuan Gao ... Ting Xie
    Wnt signaling regulates cellular redox in the germline stem cell differentiation niche via a novel regulatory mechanism, thereby controlling germ line stem cell progeny differentiation.
    1. Biochemistry and Chemical Biology
    2. Ecology

    Aggregation pheromone 4-vinylanisole promotes the synchrony of sexual maturation in female locusts

    Dafeng Chen, Li Hou ... Xianhui Wang
    4-Vinylanisole acts as maturation-accelerating pheromone to synchronize oocyte maturation of female adults in locusts.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Apicomplexan-like parasites are polyphyletic and widely but selectively dependent on cryptic plastid organelles

    Jan Janouškovec, Gita G Paskerova ... Timur G Simdyanov
    Apicomplexan-like parasites originated several times independently and many of them contain cryptic plastid organelles, which demonstrate that the parasites evolved from photosynthetic algae.
    1. Stem Cells and Regenerative Medicine

    Ovaries absent links dLsd1 to HP1a for local H3K4 demethylation required for heterochromatic gene silencing

    Fu Yang, Zhenghui Quan ... Rongwen Xi
    A Drosophila fertility gene is identified that acts as a linker between HP1a and local H3K4 demethylation during HP1a-mediated gene silencing that is required for ovary development and transposon silencing..
    1. Computational and Systems Biology
    2. Ecology

    TRex, a fast multi-animal tracking system with markerless identification, and 2D estimation of posture and visual fields

    Tristan Walter, Iain D Couzin
    Being fast, memory efficient, easy to use, and with powerful integrated tools, TRex will lower barriers of entry into, and enable more ambitious approaches to, the quantitative study of behavior.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    The neuropeptide F/nitric oxide pathway is essential for shaping locomotor plasticity underlying locust phase transition

    Li Hou, Pengcheng Yang ... Le Kang
    Two neuropeptides, NPF1a and NPF2, act via the nitric oxide signaling pathway in the locust brain to regulate the trait transition between solitary and swarming behavior.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    5′-Modifications improve potency and efficacy of DNA donors for precision genome editing

    Krishna S Ghanta, Zexiang Chen ... Craig C Mello
    Chemically modifying the 5´ends of donor DNA improves the efficiency of homology-directed repair and suppresses end-joining reactions, which will facilitate precise gene editing.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Heterogeneity of the GFP fitness landscape and data-driven protein design

    Louisa Gonzalez Somermeyer, Aubin Fleiss ... Fyodor A Kondrashov
    Orthologous proteins display different mutational robustness that can be leveraged to improve prediction of functional sequences.
    1. Developmental Biology

    Nucleoporin107 mediates female sexual differentiation via Dsx

    Tikva Shore, Tgst Levi ... Offer Gerlitz
    A housekeeping nuclear transport regulator moonlights as a critical determinant of sex-specific regulation of a somatic stem cell niche during the development of Drosophila ovaries.

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