2,691 results found
    1. Biochemistry and Chemical Biology

    A toolkit for studying cell surface shedding of diverse transmembrane receptors

    Amanda N Hayward et al.
    The modularity and unequivocal input/response of Notch signaling are harnessed to measure cell-surface shedding of diverse transmembrane receptors to identify new proteolytic switches and detect modulation of proteolysis by therapeutics.
    1. Biochemistry and Chemical Biology

    Inhibition of synucleinopathic seeding by rationally designed inhibitors

    Smriti Sangwan et al.
    Inhibitors of seeded propagation of alpha-synuclein may be developed into diagnostics and therapeutics for Parkinson's disease.
    1. Neuroscience

    Distinct spatial coordinate of visual and vestibular heading signals in macaque FEFsem and MSTd

    Lihua Yang, Yong Gu
    In both frontal and temporal–parietal visual cortices of macaque, distinct spatial coordinates of visual and vestibular signals are predominantly eye centered and head centered, respectively.
    1. Cell Biology

    Ciliary Rab28 and the BBSome negatively regulate extracellular vesicle shedding

    Jyothi S Akella et al.
    The RAB-28 GTPase regulates ciliary extracellular vesicle shedding, which may be important for neuron-glia communication.
    1. Cell Biology

    Uni-directional ciliary membrane protein trafficking by a cytoplasmic retrograde IFT motor and ciliary ectosome shedding

    Muqing Cao et al.
    During cilium-generated signaling, ciliary membrane protein trafficking is unidirectional and ciliary membrane protein composition is regulated through action in the cytoplasm of the retrograde intraflagelllar transport (IFT) motor and shedding of ciliary ectosomes.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    A Y-chromosome shredding gene drive for controlling pest vertebrate populations

    Thomas AA Prowse et al.
    A Y-chromosome shredding gene drive that depletes the pool of XY males and effects mate limitation could be a viable tool for vertebrate pest control.
    1. Neuroscience

    Angular velocity integration in a fly heading circuit

    Daniel Turner-Evans et al.
    A distinctive recurrent network motif in the Drosophila central brain enables neurons that encode angular velocity to shift population activity in compass neurons, thereby updating their heading representation whenever the fly turns.
    1. Neuroscience

    Role of visual and non-visual cues in constructing a rotation-invariant representation of heading in parietal cortex

    Adhira Sunkara et al.
    Visual information (optic flow) can be used to discount self-generated rotations and aid in the accurate representation of heading.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Shearing in flow environment promotes evolution of social behavior in microbial populations

    Gurdip Uppal, Dervis Can Vural
    Shearing in fluid flow induces or enhances budding dispersal in microbial populations, resulting in stronger cooperative behavior.
    1. Microbiology and Infectious Disease
    2. Neuroscience

    The sheddase ADAM10 is a potent modulator of prion disease

    Hermann C Altmeppen et al.
    A lack of ADAM10-mediated shedding increases prion protein levels at the plasma membrane and promotes the generation of pathological prion proteins, which accelerates prion disease in mice.

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