6,113 results found
    1. Ecology
    2. Microbiology and Infectious Disease

    Gastrointestinal helminths increase Bordetella bronchiseptica shedding and host variation in supershedding

    Nhat TD Nguyen, Ashutosh K Pathak, Isabella M Cattadori
    Helminth infected hosts are an important cause of variation in the level, frequency and duration of Bordetella bronchiseptica shedding and dynamics of infection.
    1. Microbiology and Infectious Disease
    2. Cell Biology

    The Plasmodium falciparum rhoptry protein RhopH3 plays essential roles in host cell invasion and nutrient uptake

    Emma S Sherling, Ellen Knuepfer ... Christiaan van Ooij
    The rhoptry protein RhopH3 is crucial for the invasion and growth of the malaria parasite and disruption of it provides insight into the binding of the parasite to the host red blood cell and into the formation of new import pathways.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    DnaJC7 specifically regulates tau seeding

    Valerie Ann Perez, David W Sanders ... Marc I Diamond
    Knockout of the J domain protein DnaJC7 reduces tau aggregate clearance and increases intracellular tau seeding for recombinant and human brain-derived tau seed sources.
    1. Stem Cells and Regenerative Medicine

    Identification of phenotypically, functionally, and anatomically distinct stromal niche populations in human bone marrow based on single-cell RNA sequencing

    Hongzhe Li, Sandro Bräunig ... Stefan Scheding
    Single-cell transcriptomic profiling of human bone marrow non-hematopoietic cells provides the basis for a comprehensive understanding of the cellular complexity of the hematopoietic stem cell (HSC) microenvironment and the intricate stroma-hematopoiesis crosstalk mechanisms.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Heterogeneity in transmissibility and shedding SARS-CoV-2 via droplets and aerosols

    Paul Z Chen, Niklas Bobrovitz ... Frank X Gu
    Broader case variation in respiratory viral load, and in shedding virus via droplets and aerosols, for SARS-CoV-2 than influenza A(H1N1)pdm09 facilitates greater transmission heterogeneity in the COVID-19 pandemic than the 2009 flu pandemic.
    1. Biochemistry and Chemical Biology

    A toolkit for studying cell surface shedding of diverse transmembrane receptors

    Amanda N Hayward, Eric J Aird, Wendy R Gordon
    The modularity and unequivocal input/response of Notch signaling are harnessed to measure cell-surface shedding of diverse transmembrane receptors to identify new proteolytic switches and detect modulation of proteolysis by therapeutics.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    SARS-CoV-2 shedding dynamics across the respiratory tract, sex, and disease severity for adult and pediatric COVID-19

    Paul Z Chen, Niklas Bobrovitz ... Frank X Gu
    COVID-19 severity, rather than sex or age, predicts SARS-CoV-2 kinetics, and SARS-CoV-2 viral load from lower respiratory tract specimens may predict severe disease days before clinical deterioration for COVID-19 patients.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    A structural model of the active ribosome-bound membrane protein insertase YidC

    Stephan Wickles, Abhishek Singharoy ... Roland Beckmann
    A cryo-EM structure combined with bioinformatics provide a structural view on a conserved co-translational membrane protein biogenesis pathway.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    HP1 proteins compact DNA into mechanically and positionally stable phase separated domains

    Madeline M Keenen, David Brown ... Sy Redding
    Heterochromatin proteins compartmentalize DNA into compact structures resistant to mechanical disruption but susceptible to competitive dissolution.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Transcriptome maps of general eukaryotic RNA degradation factors

    Salma Sohrabi-Jahromi, Katharina B Hofmann ... Patrick Cramer
    Mapping of 30 general RNA degradation factors onto the yeast transcriptome provides the global distribution of factors for RNA turnover and surveillance in a eukaryotic cell.

Refine your results by:

Type
Research categories