The decision to commit to cell division-the Start transition-in budding yeast is governed by time integration of G1 cyclin-CDK activity by the transcription factor Whi5.

Editors' Summary: The results in this Replication Study could not be interpreted.

Anti-inflammatory effects of resveratrol are mediated by the estrogen receptor to coordinate a complex array of transcriptional coregulators, suggesting that estrogenic effects must be considered in the complex polypharmacology of resveratrol.

An array of cytosolic co-chaperones and chaperones helps to maintain newly synthesized mitochondrial outer membrane proteins in an import competent state.

Inhibition reduces the neuronal representation of acoustic signals to enhance temporal precision in the auditory brainstem.

By distributing regulation to both the GTPase and downstream kinases, the Mitotic Exit Network creates a single signal from spatial and temporal inputs.

In astrocytes, there exists an intrinsic spatial threshold of subcellular calcium levels that triggers an astrocyte calcium surge throughout the cell, demonstrating cellular astrocyte calcium integration of time and space.

Dopamine neurons signal value prediction errors (VPEs) integrating information about both reward and aversion, in low reward contexts, whereas VPEs in some dopamine neurons are distorted in high reward contexts.