10,928 results found
    1. Developmental Biology
    2. Neuroscience

    Frazzled promotes growth cone attachment at the source of a Netrin gradient in the Drosophila visual system

    Orkun Akin, S Lawrence Zipursky
    Direct observation in the developing fly brain indicates that the response of a growth cone in a gradient of a guidance cue is adhesion to the source of the cue rather than attraction by the gradient.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Bacterial vampirism mediated through taxis to serum

    Siena J Glenn, Zealon Gentry-Lear ... Arden Baylink
    Enteric bacteria associated with bloodstream infections are attracted to human serum through L-serine and the chemoreceptor Tsr, and in an enterohemorrhagic lesion model use chemotaxis to invade damaged vasculature.
    1. Microbiology and Infectious Disease

    Highly parallelized droplet cultivation and prioritization of antibiotic producers from natural microbial communities

    Lisa Mahler, Sarah P Niehs ... Miriam A Rosenbaum
    This microscale cultivation strategy will help in the discovery of novel bacterial species and their prioritization for antibiotic screening campaigns.
    1. Physics of Living Systems

    Cellular organization in lab-evolved and extant multicellular species obeys a maximum entropy law

    Thomas C Day, Stephanie S Höhn ... Peter J Yunker
    The distributions of cellular neighborhood volumes in two very different multicellular species - snowflake yeast and Volvox carteri - are found to obey a common functional form arising from maximum entropy consideration, despite great differences in their cell division processes.
    1. Cell Biology
    2. Developmental Biology

    Dpp from the anterior stripe of cells is crucial for the growth of the Drosophila wing disc

    Shinya Matsuda, Markus Affolter
    A recent report proposing that the dpp stripe (the main source of the protein dpp) is dispensable for Drosophila wing disc growth missed the critical role on growth due to imprecise spatial removal of dpp.
    1. Computational and Systems Biology
    2. Developmental Biology

    MorphoGraphX: A platform for quantifying morphogenesis in 4D

    Pierre Barbier de Reuille, Anne-Lise Routier-Kierzkowska ... Richard S Smith
    MorphoGraphX summarizes full 3D datasets as curved surface images (2.5D), enabling the efficient quantification of growth and gene expression data from large time-lapse volumetric datasets.
    1. Cell Biology
    2. Developmental Biology

    Pleiotropic effects of BAFF on the senescence-associated secretome and growth arrest

    Martina Rossi, Carlos Anerillas ... Myriam Gorospe
    The levels of the cytokine BAFF increase across senescence paradigms, in turn triggering a secretory phenotype in some senescent cells and activating p53 in other senescent cells.
    1. Computational and Systems Biology
    2. Neuroscience

    A simple generative model of the mouse mesoscale connectome

    Sid Henriksen, Rich Pang, Mark Wronkiewicz
    A realistic model of the connections between local populations of neurons in the adult mouse brain can be constructed based on just two biologically plausible rules.
    1. Cancer Biology

    Paracrine signalling between intestinal epithelial and tumour cells induces a regenerative programme

    Guillaume Jacquemin, Annabelle Wurmser ... Silvia Fre
    Studies of organoid morphogenesis, combined with proteomics and molecular profiling, identify the THBS1-YAP axis as a signalling mechanism that mediates paracrine communication between tumour cells and their wildtype epithelial neighbours.
    1. Microbiology and Infectious Disease

    A Tad-like apparatus is required for contact-dependent prey killing in predatory social bacteria

    Sofiene Seef, Julien Herrou ... Tâm Mignot
    First identification of the molecular determinants driving contact-dependent predation in Myxococcus..

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