8,173 results found
    1. Immunology and Inflammation

    Variations in HLA-B cell surface expression, half-life and extracellular antigen receptivity

    Brogan Yarzabek, Anita J Zaitouna ... Malini Raghavan
    Lymphocytes and monocytes maintain their cell surface HLA-B via different mechanisms, which in turn differently influence cell-surface expression, half-life and peptide receptivity of HLA-B allotypes.
    1. Microbiology and Infectious Disease

    Modifications at K31 on the lateral surface of histone H4 contribute to genome structure and expression in apicomplexan parasites

    Fabien Sindikubwabo, Shuai Ding ... Mohamed-ali Hakimi
    A versatile acetylation-methylation switch at lysine 31 on the lateral surface of histone H4 contributes to chromatin structure in apicomplexan parasites.
    1. Neuroscience

    The C-terminal helix 9 motif in rat cannabinoid receptor type 1 regulates axonal trafficking and surface expression

    Alexandra Fletcher-Jones, Keri L Hildick ... Jeremy M Henley
    An intracellular H9 motif facilitates the highly localised axonal surface expression of CB1R.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    AP-2α and AP-2β cooperatively function in the craniofacial surface ectoderm to regulate chromatin and gene expression dynamics during facial development

    Eric Van Otterloo, Isaac Milanda ... Trevor Williams
    In addition to a neural crest cell specific role, AP-2α and AP-2ß cooperatively promote craniofacial development through regulating chromatin and gene expression dynamics in the facial surface ectoderm.
    1. Medicine
    2. Stem Cells and Regenerative Medicine

    Lysosomal protein surface expression discriminates fat- from bone-forming human mesenchymal precursor cells

    Jiajia Xu, Yiyun Wang ... Aaron W James
    CD107a expression divides osteogenic from adipogenic perivascular precursor cells within human white adipose tissue.
    1. Microbiology and Infectious Disease

    Multimodal HLA-I genotype regulation by human cytomegalovirus US10 and resulting surface patterning

    Carolin Gerke, Liane Bauersfeld ... Anne Halenius
    Analysis of human cytomegalovirus-encoded glycoprotein US10 targeting human leucocyte antigen class I molecules reveals a multimodal strategy, resulting in a geno- and allotypic-dependent effects.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Expression site attenuation mechanistically links antigenic variation and development in Trypanosoma brucei

    Christopher Batram, Nicola G Jones ... Markus Engstler
    The VSG gene controls its monoallelic expression, and expression site activity determines developmental progression.
    1. Immunology and Inflammation

    Fine-tuning spatial-temporal dynamics and surface receptor expression support plasma cell-intrinsic longevity

    Zhixin Jing, Phillip Galbo ... David Fooksman
    Enigmatic long-lived plasma cells display an enhanced clustering in bone marrow niches and require CXCR4 for retention, survival, and maintenance of antibody titers.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Simultaneous trimodal single-cell measurement of transcripts, epitopes, and chromatin accessibility using TEA-seq

    Elliott Swanson, Cara Lord ... Peter J Skene
    Simultaneous multimodal measurement of chromatin accessibility, gene expression, and protein expression provides a unified view of the molecular underpinnings of immune cell state in health and disease.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    PI(3,4,5)P3 allosteric regulation of repressor activator protein 1 controls antigenic variation in trypanosomes

    Abdoulie O Touray, Rishi Rajesh ... Igor Cestari
    Nuclear phosphoinositide signaling controls telomeric gene repression and activation essential for switching expression of surface antigen genes and thus antigenic variation.

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